The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Spatial Localization in NMR Spectroscopy in Vivo
Abstract
Spatial localization techniques are necessary for in vivo NMR spectroscopy involving heterogeneous organisms. Localization by surface coil NMR detection alone is generally inadequate for deep-lying organs due to contaminating signals from intervening surface tissues. However, localization to preselected planar volumes can be accomplished using a single selective excitation pulse in the presence of a pulsed magnetic field gradient, yielding depth-resolved surface coil spectra (DRESS). Within selected planes, DRESS are spatially restricted by the surface coil sensitivity profiles to disk-shaped volumes whose radii increase with depth, notwithstanding variations in the NMR signal density distribution. Nevertheless, DRESS is a simple and versatile localization procedure that is readily adaptable to spectral relaxation time measurements by adding inversion or spin-echo refocusing pulses or to in vivo solvent-suppressed spectroscopy of proton (1H) metabolites using a combination of chemical-selective RF pulses. Also, the spatial information gathering efficiency of the technique can be improved to provide simultaneous acquisition of spectra from multiple volumes by interleaving excitation of adjacent planes within the normal relaxation recovery period. The spatial selectivity can be improved by adding additional selective excitation spin-echo refocusing pulses to achieve full, three-dimensional point resolved spectroscopy (PRESS) in a single excitation sequence. Alternatively, for samples with short spin-spin relaxation times, DRESS can be combined with other localization schemes, such as image-selected in vivo spectroscopy (ISIS), to provide complete gradient controlled three-dimensional localization with a reduced number of sequence cycles.
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Cites
Determination of Intracellular pH by 31P Magnetic Resonance
Moon, R. B., & Richards, J. H. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43389-9 · Cited by 1,189
Image-selected in Vivo spectroscopy (ISIS). A new technique for spatially selective nmr spectroscopy
Ordidge, R. J., Connelly, A., & Lohman, J. A. B. (1986) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(86)90031-4 · Cited by 811
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.
Behar, K. L., den Hollander, J. A., Stromski, M. E., Ogino, T., Shulman, R. G., Petroff, O. A., & Prichard, J. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.16.4945 · Cited by 292
Depth-resolved surface-coil spectroscopy (DRESS) for in Vivo 1H, 31P, and 13C NMR
Bottomley, P. A., Foster, T. B., & Darrow, R. D. (1984) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(84)90179-3 · Cited by 290
Self-citationSelective population inversion in NMR
Silver, M. S., Joseph, R. I., Chen, C.-N., Sank, V. J., & Hoult, D. I. (1984) · Nature · doi:10.1038/310681a0 · Cited by 205
Noninvasive, nondestructive approaches to cell bioenergetics.
Chance, B., Eleff, S. M., & Leigh, J. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7430 · Cited by 155
4480228 Selective volume method for performing localized NMR spectroscopy
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Self-citationBottomley, P. A., Edelstein, W. A., Foster, T. H., & Adams, W. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.7.2148 · Cited by 115
Self-citationSpatial localization in 31P and 13C NMR spectroscopy in Vivo using surface coils
Bottomley, P. A., Edelstein, W. A., Hart, H. R., Jr., et al. (1984) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910010311 · Cited by 38
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Cited by
Moseley, M. E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M. F., & Weinstein, P. R. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140218 · Cited by 1,644
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540
Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522
ROSENBERG, D. R., MacMASTER, F. P., KESHAVAN, M. S., FITZGERALD, K. D., STEWART, C. M., & MOORE, G. J. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200009000-00008 · Cited by 377
Pope, W. B., Prins, R. M., Albert Thomas, M., Nagarajan, R., Yen, K. E., Bittinger, M. A., Salamon, N., Chou, A. P., Yong, W. H., Soto, H., et al. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0737-8 · Cited by 318
Metadata
- Authors
- BOTTOMLEY, P. A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1987-11
- Volume
- 508
- Issue
- 1
- Pages
- 333-348
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2058027749
- Cited by
- 1,378
- References
- 9
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
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