Structure and Function of the Estrogen Receptor

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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Functional domains of the human estrogen receptor

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Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

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The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

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Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

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Untitled work

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The human estrogen receptor has two independent nonacidic transcriptional activation functions

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Cloning and expression of full-length cDNA encoding human vitamin D receptor.

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Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

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Role of the two activating domains of the oestrogen receptor in the cell‐type and promoter‐context dependent agonistic activity of the anti‐oestrogen 4‐hydroxytamoxifen.

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Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

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The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

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Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

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The common 90‐kd protein component of non‐transformed ‘8S’ steroid receptors is a heat‐shock protein.

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A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

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COUP transcription factor is a member of the steroid receptor superfamily

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Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

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Immunochemical studies of estrogen receptors

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Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

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Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

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Distinct classes of transcriptional activating domains function by different mechanisms

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Cooperation of proto‐signals for nuclear accumulation of estrogen and progesterone receptors.

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Identification of two transactlvation domains in the mouse oestrogen receptor

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Nucleocytoplasmic shuttling of the progesterone receptor.

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Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

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Commitment and activation at pol II promoters: a tail of protein-protein interactions.

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Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

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v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA

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Novel steroidal pure antiestrogens

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The Mechanism of ICI 164,384 Antiestrogenieity Involves Rapid Loss of Estrogen Receptor in Uterine Tissue

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Cell‐specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

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Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

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Cooperative binding of estrogen receptor to imperfect estrogen‐responsive DNA elements correlates with their synergistic hormone‐dependent enhancer activity.

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Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.

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Examination of the DNA-Binding Ability of Estrogen Receptor in Whole Cells: Implications for Hormone- Independent Transactivation and the Actions of Antiestrogens

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Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination.

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Identification of Cysteine 530 as the Covalent Attachment Site of an Affinity-labeling Estrogen (Ketononestrol Aziridine) and Antiestrogen (Tamoxifen Aziridine) in the Human Estrogen Receptor

Harlow, K. W., Smith, D. N., Katzenellenbogen, J. A., Greene, G. L., & Katzenellenbogen, B. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71519-6 · Cited by 120 · see citing works

The transcriptional activation function located in the hormone‐binding domain of the human oestrogen receptor is not encoded in a single exon.

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Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

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Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster.

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Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element.

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Mutational Analysis Identifies a New Functional Domain of the Thyroid Hormone Receptor

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The effect of anti-oestrogens on cell growth and progesterone receptor concentration in human endometrial cancer cells (Ishikawa)

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Effect of antioestrogens on the DNA binding activity of oestrogen receptorsin vitro

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Antiestrogen action in mammary cancer and in fetal cells

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The oxytocin receptor system: structure, function, and regulation

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Overview of resistance to systemic therapy in patients with breast cancer

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The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands

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Basic Guide to the Mechanisms of Antiestrogen Action

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Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

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Structural Features of Alkylphenolic Chemicals Associated with Estrogenic Activity

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Genetics of Osteoporosis

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27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

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Oestrogenic activity of parabens in MCF7 human breast cancer cells

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Plasma Membrane Estrogen Receptors Exist and Functions as Dimers

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Rapid screening of environmental chemicals for estrogen receptor binding capacity.

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Identification of Estrogen Receptor β2, A Functional Variant of Estrogen Receptor β Expressed in Normal Rat Tissues

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THE NUCLEAR HORMONE RECEPTOR GENE SUPERFAMILY

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Cellular Distribution and Gene Regulation of Estrogen Receptorsα and β in the Rat Pituitary Gland¹

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Regulation of Rat Testis Gonocyte Proliferation by Platelet-Derived Growth Factor and Estradiol: Identification of Signaling Mechanisms Involved

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Ligand-Based Identification of Environmental Estrogens

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Two Separate Mechanisms for Ligand-Independent Activation of the Estrogen Receptor

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EXOESTROGENS: MECHANISMS OF ACTION AND STRATEGIES FOR IDENTIFICATION AND ASSESSMENT

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Estrogen Receptor Antagonist ICI182,780 Exacerbates Ischemic Injury in Female Mouse

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Phytoestrogens and Mycoestrogens Bind to the Rat Uterine Estrogen Receptor

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Signal Transducers and Activators of Transcription as Downstream Targets of Nongenomic Estrogen Receptor Actions

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Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L‐type Ca 2+ channels in smooth muscle cells

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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.

Lobenhofer, E. K., Hüper, G., Iglehart, J. D., & Marks, J. R. (2000) · PubMed · Cited by 136 · see citing works

The Estrogen Receptor's Involvement in Osteoblasts' Adaptive Response to Mechanical Strain

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Paraben Toxicology

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Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells

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Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation

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Identification of Estrogen Receptor 2, A Functional Variant of Estrogen Receptor Expressed in Normal Rat Tissues

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Physiology of the Menstrual Cycle

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Inhibition of Rainbow Trout (Oncorhynchus mykiss) Estrogen Receptor Activity by Cadmium1

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Identification and Functional Separation of Retinoic Acid Receptor Neutral Antagonists and Inverse Agonists

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Yeast Two-hybrid System Demonstrates That Estrogen Receptor Dimerization Is Ligand-dependent in Vivo

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Oxytocin Increases Glucose Uptake in Neonatal Rat Cardiomyocytes

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Mechanical strain activates estrogen response elements in bone cells

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Selective Expression of Estrogen Receptor α and β Isoforms in Human Pituitary Tumors1

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Osteoblast-Like Cells From Estrogen Receptor α Knockout Mice Have Deficient Responses to Mechanical Strain

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p53, a Target of Estrogen Receptor (ER) α, Modulates DNA Damage-induced Growth Suppression in ER-positive Breast Cancer Cells

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G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

Sun, Y., Leng, P., Guo, P., Gao, H., Liu, Y., Li, C., Li, Z., & Zhang, H. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00360-w · Cited by 87 · see citing works

Free energies of binding of polychlorinated biphenyls to the estrogen receptor from a single simulation

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Diluted Mainstream Cigarette Smoke Condensates Activate Estrogen Receptor and Aryl Hydrocarbon Receptor-Mediated Gene Transcription

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Structure–activity relationships for gene activation oestrogenicity: Evaluation of a diverse set of aromatic chemicals

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