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In Vitro Organogenesis of Liver Tissuea
Abstract
The high metabolic rate of hepatocytes severely limits the mass of cells which can be transplanted without a vascular supply. We are developing an alternative approach in which vascularized tissue is grown ex vivo for anastamosis into the portal vein. Here, we discuss the key design issues for in vitro organogenesis of vascularized hepatic tissue, describe a fabrication approach for making complex degradable polymer scaffolds to organize cells in three dimensions on the scale of hundreds of microns, and demonstrate the feasibility of using these scaffolds for in vitro tissue organization in mixed-cell cultures.
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Cited by
Tissue Engineering--Current Challenges and Expanding Opportunities
Griffith, L. G., & Naughton, G. (2002) · Science · doi:10.1126/science.1069210 · Cited by 2,343
Self-citationRecent advances in 3D printing of biomaterials
Chia, H. N., & Wu, B. M. (2015) · Journal of Biological Engineering · doi:10.1186/s13036-015-0001-4 · Cited by 1,734
Self-citationDepartment of Materials, U. O. O., Sachlos, E., & Czernuszka, J. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a03 · Cited by 1,303
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Bhatia, S. N., Balis, U. J., Yarmush, M. L., & Toner, M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.1883 · Cited by 890
Metadata
- Authors
- GRIFFITH, L. G., WU, B., CIMA, M. J., POWERS, M. J., CHAIGNAUD, B., & VACANTI, J. P.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1997-12
- Volume
- 831
- Issue
- 1
- Pages
- 382-397
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2123375068
- Cited by
- 170
- References
- 0
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- GRIFFITH, L. G., WU, B., CIMA, M. J., POWERS, M. J., CHAIGNAUD, B., & VACANTI, J. P. (1997). In Vitro Organogenesis of Liver Tissuea. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.1997.tb52212.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
