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Survival and Disease Complications in Thalassemia Major
Abstract
A bstract: We studied survival and disease complications in 1,146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow‐up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970‐1974. Patients who died had a serum ferritin level, measured the year before death, significantly higher than those who survived. Diabetes was present in 5.4% of the patients; heart failure in 6.4%; arrhythmias in 5.0%, thrombosis in 1.1%, hypothyroidism in 11.6%, HIV infection in 1.8%. Hypogonadism was diagnosed in 55% of 578 patients who had reached pubertal age: 83.5% of hypogonadic females and 78.6% of males were receiving substitutive hormonal therapy. In conclusion, the survival of patients with thalassemia major is good and improving, but the prevalence of severe complications is still high.
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Citations
Cited by
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PENNELL, D. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.040 · Cited by 747
Simcox, J. A., & McClain, D. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.007 · Cited by 545
The hypercoagulable state in thalassemia
Eldor, A., & Rachmilewitz, E. A. (2002) · Blood · doi:10.1182/blood.v99.1.36 · Cited by 503
Anderson, L. J., Westwood, M. A., Holden, S., Davis, B., Prescott, E., Wonke, B., Porter, J. B., Malcolm Walker, J., & Pennell, D. J. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05202.x · Cited by 414
Severe bacterial infection in transfusion-dependent patients with thalassemia major
Wang, S.-C., Lin, K.-H., Chern, J. P. S., Lu, M.-Y., Jou, S.-T., Lin, D.-T., & Lin, K.-S. (2003) · Clinical Infectious Diseases · doi:10.1086/378062 · Cited by 80
Metadata
- Authors
- BORGNA‐PIGNATTI, C., RUGOLOTTO, S., DE STEFANO, P., PIGA, A., DI GREGORIO, F., GAMBERINI, M. R., SABATO, V., MELEVENDI, C., CAPPELLINI, M. D., & VERLATO, G.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1998-06
- Volume
- 850
- Issue
- 1
- Pages
- 227-231
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2061809972
- Cited by
- 343
- References
- 0
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- BORGNA‐PIGNATTI, C., RUGOLOTTO, S., DE STEFANO, P., PIGA, A., DI GREGORIO, F., GAMBERINI, M. R., SABATO, V., MELEVENDI, C., CAPPELLINI, M. D., & VERLATO, G. (1998). Survival and Disease Complications in Thalassemia Major. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.1998.tb10479.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
