Cited by 545Iron Metabolism and DisordersTrace Elements in HealthAdipokines, Inflammation, and Metabolic Diseases

Iron and diabetes risk

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Simcox, Judith A., McClain, Donald A.·2013·Cell Metabolism

Abstract

Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.

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Crossref · 10.1016/j.cmet.2013.02.007

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Authors
Simcox, J. A., & McClain, D. A.
Affiliations
University of Utah (US)
Corresponding author
McClain, Donald A.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2013-03
Volume
17
Issue
3
Pages
329-341
ISSN
1550-4131 (ISSN-L)
OpenAlex
W1976913734
Cited by
545
References
170
Citations by year
2026: 36 · 2025: 40 · 2024: 60 · 2023: 61 · 2022: 61 · 2021: 51 · 2020: 43 · 2019: 34 · 2018: 42 · 2017: 32 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 9 · 2012: 1
FWCI
4.15
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs (I01 BX001140)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-081842, R01DK081842, R21DK096288, T32DK091317)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
iron overload, diabetes risk, hereditary hemochromatosis, thalassemia, dietary iron, beta-cell failure, insulin resistance, oxidative stress, adipokines, signal transduction, fuel homeostasis
MeSH terms
Diabetes Mellitus, Type 2, Glucose, Hemochromatosis, Homeostasis, Humans, Insulin Resistance, Models, Biological, Iron Overload, Iron, Dietary, Lipid Metabolism, Insulin-Secreting Cells, Adiponectin

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