Iron and diabetes risk
Open accessAbstract
Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.
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Underlying mechanisms linking iron status to diabetes risk seem manifold and likely include oxidative stress and modulation of intracellular signaling cascades.
“Underlying mechanisms seem to be manifold and likely include oxidative stress and modulation of intracellular signaling cascades (44).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [44]
Elevated iron status as assessed by ferritin was directly related to diabetes risk in EPIC-Potsdam.
“Consistent with other studies (44), elevated iron status as assessed by ferritin was directly related to the risk of diabetes in EPIC-Potsdam (13).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [44]
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Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
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- Authors
- Simcox, J. A., & McClain, D. A.
- Affiliations
- University of Utah (US)
- Corresponding author
- McClain, Donald A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 17
- Issue
- 3
- Pages
- 329-341
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3648340
- OpenAlex
- W1976913734
- Cited by
- 545
- References
- 170
- Citations by year
- 2026: 36 · 2025: 40 · 2024: 60 · 2023: 61 · 2022: 61 · 2021: 51 · 2020: 43 · 2019: 34 · 2018: 42 · 2017: 32 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 9 · 2012: 1
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX001140)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-081842, R01DK081842, R21DK096288, T32DK091317)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- iron overload, diabetes risk, hereditary hemochromatosis, thalassemia, dietary iron, beta-cell failure, insulin resistance, oxidative stress, adipokines, signal transduction, fuel homeostasis
- MeSH terms
- Diabetes Mellitus, Type 2, Glucose, Hemochromatosis, Homeostasis, Humans, Insulin Resistance, Models, Biological, Iron Overload, Iron, Dietary, Lipid Metabolism, Insulin-Secreting Cells, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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