Desensitization of Nicotinic Receptors in the Central Nervous System
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α4β2 nAChRs desensitize at nicotine concentrations lower than those required for activation and are mostly desensitized in brains of smokers.
“These receptors desensitize at nicotine concentrations lower than those required for activation (Fenster et al. 1999) and, as a result, are mostly desensitized in brains of smokers (Brody et al. 2006).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Fenster et al. 1999
Cites
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308 · see citing works
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<scp>N</scp> icotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 582 · see citing works
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559 · see citing works
Dineley, K. T., Xia, X., Bui, D., Sweatt, J. D., & Zheng, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200164200 · Cited by 212 · see citing works
Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
Rezvani, K., Teng, Y., Shim, D., & De Biasi, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-07.2007 · Cited by 113 · see citing works
- Authors
- FENSTER, C. P., HICKS, J. H., BECKMAN, M. L., COVERNTON, P. J. O., QUICK, M. W., & LESTER, R. A. J.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- LESTER, R.A. J.
- ORCID
- BECKMAN, M. L.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 868
- Issue
- 1
- Pages
- 620-623
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2027323167
- Cited by
- 50
- References
- 1
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 31669)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, receptor desensitization, central nervous system, nicotinic agonists, ligand-gated ion channels
- MeSH terms
- Animals, Brain, Enzyme Inhibitors, gamma-Aminobutyric Acid, Indoles, Maleimides, Neurons, Nicotine, Oocytes, Protein Kinase C, Receptors, Nicotinic, Xenopus, Patch-Clamp Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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