Predator Exposure Produces Retrograde Amnesia and Blocks Synaptic Plasticity: Progress toward Understanding How the Hippocampus Is Affected by Stress
Abstract
A vast amount of research has been devoted to understanding the role of the hippocampus in learning and memory. Damage to the hippocampus results in severe cognitive impairments in a broad range of species, including humans and rats. Complementary work has shown that chronic stress, which can result in hippocampal cell death, impairs hippocampal‐specific learning and memory. For example, spatial learning, which is impaired in animals with lesions of the hippocampus, is impaired in chronically stressed animals. Moreover, acute stress also impairs hippocampal‐dependent learning and memory. This chapter reviews our studies on the effects of acute stress on hippocampal‐dependent memory and synaptic plasticity. Our recent findings indicate that exposing rats to a predator, which is an intense stressor, impairs cognitive and electrophysiological measures of hippocampal functioning.
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Stress appears to reduce the efficiency of hippocampal processing, but does not produce the equivalent of a hippocampal lesion.
“We have commented previously that stress appears to reduce the efficiency of hippocampal processing, but does not produce the equivalent of a hippocampal lesion (Diamond et al. [52]; Diamond and Park [177]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond and Park [177]
Cites
Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276 · see citing works
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The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Self-citationDiamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“We have commented previously that stress appears to reduce the e ffi ciency of hippocampal processing, but does not produce the equivalent of a hippocampal lesion (Dia-mond et al. [52]; Diamond and Park [177]).”
BackgroundInfluentialSelf-citationEstablishing an Agenda for Translational Research on PTSD
MILLER, M. M., & McEWEN, B. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.023 · Cited by 101 · see citing works
Vouimba, R.-M., Muñoz, C., & Diamond, D. M. (2006) · Stress · doi:10.1080/10253890600610973 · Cited by 96 · see citing works
Self-citationDiamond, D. M., Park, C. R., & Woodson, J. C. (2004) · Hippocampus · doi:10.1002/hipo.10186 · Cited by 95 · see citing works
Self-citationImpaired memory following predatory stress in mice is improved by fluoxetine
El Hage, W., Peronny, S., Griebel, G., & Belzung, C. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.028 · Cited by 28 · see citing works
- Authors
- DIAMOND, D. M., & PARK, C. R.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- DIAMOND, DAVID M.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2000-06
- Volume
- 911
- Issue
- 1
- Pages
- 453-455
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2078533645
- Cited by
- 37
- References
- 1
- Citations by year
- 2018: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- predator exposure, retrograde amnesia, synaptic plasticity, hippocampus, acute stress, chronic stress, hippocampal-dependent memory, spatial learning, hippocampal cell death, stress-induced cognitive impairment
- MeSH terms
- Amnesia, Animals, Hippocampus, Neuronal Plasticity, Predatory Behavior, Stress, Psychological, Synapses
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