Pharmacological Issues in the Treatment of Tuberculosis
Abstract
A bstract: A thorough review of the clinical trial data combined with new in vitro experimental information may make the optimization of dosages of TB drugs possible. Several factors can affect the selection and dosage of TB drugs including hepatic and renal impairment, pregnancy, duration of disease before treatment, and extent of debilitation. Drug interactions and pharmacodynamics must be considered, and their roles are discussed.
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Central neural processing can sometimes be modified so that initially peripherally induced central sensitization becomes independent of peripheral sensitization through mechanisms similar to those underlying memory.
“Sometimes, however, central neural processing can be 'modified' so that initially peripherally induced central sensitization becomes independent of peripheral sensitization”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Melzack et al., 2001
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- Authors
- PELOQUIN, C. A.
- Affiliations
- National Jewish Health (US)
- Corresponding author
- PELOQUIN, CHARLES A.
- ORCID
- PELOQUIN, CHARLES A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2001-12
- Volume
- 953b
- Issue
- 1
- Pages
- 157-164
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2002657314
- Cited by
- 82
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- tuberculosis, antitubercular agents, drug dosing optimization, drug interactions, pharmacodynamics, liver dysfunction, renal dysfunction, pregnancy, treatment duration, debilitation
- MeSH terms
- Animals, Antitubercular Agents, Humans, Kidney Diseases, Liver Diseases, Mycobacterium tuberculosis, Drug Monitoring, Tuberculosis, Multidrug-Resistant
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