Behavior and Stress Reactivity in Mouse Strains with Mitochondrial DNA Variations
Abstract
We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J‐mt FVB/N mice were significantly more anxious in the elevated plus‐maze test than C57BL/6J‐mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus‐maze test. Our findings suggest that mitochondrial variations could affect anxiety‐like behavior as well as corticosterone and neurotransmitter response to psychological stress.
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Genetically modified mice strains bred on C57BL/6J background are extremely useful in understanding the genetic basis of depression-like behavioral traits.
“Genetically modified mice strains bred on C57BL/6J background are extremely useful in understanding the genetic basis of depression-like behavioral traits26,42,43.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [42]
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A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Oxidative stress in anxiety and comorbid disorders
Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365 · see citing works
Picard, M., McManus, M. J., Gray, J. D., Nasca, C., Moffat, C., Kopinski, P. K., Seifert, E. L., McEwen, B. S., & Wallace, D. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515733112 · Cited by 293 · see citing works
- Authors
- Gimsa, U., Kanitz, E., Otten, W., & Ibrahim, S. M.
- Affiliations
- Research Institute for Farm Animal Biology (FBN) (DE)
- University of Rostock (DE)
- Corresponding author
- Gimsa, Ulrike
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2009-02
- Volume
- 1153
- Issue
- 1
- Pages
- 131-138
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2165449514
- Cited by
- 39
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universität Rostock
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial DNA variation, mitochondrial replacement, anxiety-like behavior, stress reactivity, social defeat stress, neuroendocrine regulation, serotonergic system, dopaminergic system, C57BL/6J mice, AKR/J mice, FVB mice, elevated plus maze
- MeSH terms
- Animals, Behavior, Brain, Corticosterone, DNA, Mitochondrial, Male, Mice, Inbred Strains, Stress, Psychological, Genetic Variation, Neurotransmitter Agents, Maze Learning, Mice
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