Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress
Open accessAbstract
Significance: In humans and animals, stress triggers multisystemic physiological responses that vary in nature and magnitude. The organism’s response to stress, rather than actual stressors, leads to allostatic load that predisposes to disease. This study in mice demonstrates that a specific cellular component that sustains life via energy transformation and intracellular signaling—the mitochondrion—influences the organism’s integrated response to psychological stress. Each component of the stress response assessed was modified by at least one mitochondrial defect. When analyzed collectively, stress-induced neuroendocrine, inflammatory, metabolic, and transcriptional responses coalesced into unique signatures that distinguish groups based on their mitochondrial genotype. This work shows that mitochondria can regulate complex whole-body physiological responses, impacting stress perception at the cellular and organismal levels.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 2× · see citing works
“Rather, it is the organism’s responses to stress that have the potential to result in physiological dysregulation and dysfunction, culminating in allostatic load and disease (41).”
BackgroundSelf-citationStress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092 · see citing works
Self-citationPhysiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 1× · see citing works
“The underlying mechanisms involve dysregulation of peripheral stress response elements including the hypothalamic–pituitary–adrenal (HPA) axis and glucocorticoids (3), the sympathetic adrenal–medullary (SAM) axis and catecholamines (4), systemic inflammation (5), and the “diabetic-like” state of excess circulating glu…”
BackgroundSelf-citationMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168 · see citing works
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143 · see citing works
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works
Esposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961 · see citing works
MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis
Xia, J., Mandal, R., Sinelnikov, I., Broadhurst, D., & Wishart, D. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks374 · Cited by 1,146 · see citing works
Bullitt, E. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960402 · Cited by 1,059 · see citing works
Plasma phospholipids identify antecedent memory impairment in older adults
Mapstone, M. E., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,031 · see citing works
Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease
Gorman, G., Schaefer, A., Ng, Y., Gomez, N., Blakely, E., Alston, C., Feeney, C., Horvath, R., Yu-Wai-Man, P., Chinnery, P., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24362 · Cited by 921 · see citing works
Olfactory exposure to males, including men, causes stress and related analgesia in rodents
Sorge, R. E., Martin, L. J., Isbester, K. A., Sotocinal, S. G., Rosen, S., Tuttle, A. H., Wieskopf, J. S., Acland, E. L., Dokova, A., Kadoura, B., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2935 · Cited by 905 · see citing works
Activity-driven local ATP synthesis is required for synaptic function
Rangaraju, V., Calloway, N., & Ryan, T. A. (2014) · Cell · doi:10.1016/j.cell.2013.12.042 · Cited by 836 · see citing works
Glucocorticoids and insulin resistance: old hormones, new targets
ANDREWS, R. C., & WALKER, B. R. (1999) · Clinical Science · doi:10.1042/cs0960513 · Cited by 731 · see citing works
Mitochondrial Energetics and Therapeutics
Wallace, D. C., Fan, W., & Procaccio, V. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092314 · Cited by 727 · see citing works
Self-citationThe role of mitochondria in insulin resistance and type 2 diabetes mellitus
Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · cited 1× · see citing works
“Third, stress-induced physiological responses such as SAM hyperactivation (21), peripheral insulin resistance leading to hyperglycemia and metabolic syndrome (22), and inflammation (23, 24) can be triggered autonomously by mitochondrial dysfunction alone.”
BackgroundGraham, B. H., Waymire, K. G., Cottrell, B. A., Trounce, I. A., MacGregor, G. R., & Wallace, D. C. (1997) · Nature Genetics · doi:10.1038/ng0797-226 · Cited by 556 · see citing works
Self-citationJones, B. N., & Gilligan, J. P. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)90918-5 · Cited by 522 · see citing works
Plasma Catecholamines in Stress and Exercise
Dimsdale, J. E. (1980) · JAMA · doi:10.1001/jama.1980.03300300018017 · Cited by 516 · see citing works
Monogenic Mitochondrial Disorders
Koopman, W. J. H., Willems, P. H. G. M., & Smeitink, J. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1012478 · Cited by 515 · see citing works
Stimulation of systemic low-grade inflammation by psychosocial stress.
Rohleder, N. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000049 · Cited by 497 · see citing works
A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
Fan, W., Waymire, K. G., Narula, N., Li, P., Rocher, C., Coskun, P. E., Vannan, M. A., Narula, J., MacGregor, G. R., & Wallace, D. C. (2008) · Science · doi:10.1126/science.1147786 · Cited by 466 · see citing works
Self-citationStress hormones in health and illness: The roles of work and gender
Lundberg, U. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.014 · Cited by 466 · see citing works
The nexus of chromatin regulation and intermediary metabolism
Gut, P., & Verdin, E. M. (2013) · Nature · doi:10.1038/nature12752 · Cited by 419 · see citing works
Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids
Picard, M., Juster, R.-P., & McEwen, B. S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.22 · Cited by 405 · see citing works
Self-citationHeteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition
Sharpley, M. S., Marciniak, C., Eckel‐Mahan, K. L., McManus, M. J., Crimi, M., Waymire, K. G., Lin, C. S., Masubuchi, S., Friend, N., Koike, M. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.004 · Cited by 384 · see citing works
Self-citationMitochondria as key components of the stress response
Manoli, I., Alesci, S., Blackman, M. R., Su, Y. A., Rennert, O. M., & Chrousos, G. P. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.04.004 · Cited by 377 · see citing works
Reactive Oxygen Species Production by Mitochondria
Lambert, A. J., & Brand, M. D. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-521-3_11 · Cited by 374 · see citing works
Courchet, J., Lewis, T. L., Lee, S., Courchet, V., Liou, D.-Y., Aizawa, S., & Polleux, F. (2013) · Cell · doi:10.1016/j.cell.2013.05.021 · Cited by 351 · see citing works
Dissociation of ACTH and glucocorticoids
Bornstein, S. R., Engeland, W. C., Ehrhart-Bornstein, M., & Herman, J. P. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.01.009 · Cited by 345 · see citing works
A mitochondrial bioenergetic etiology of disease
Wallace, D. C. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61398 · Cited by 342 · see citing works
Self-citationA neurological perspective on mitochondrial disease
McFarland, R., Taylor, R. W., & Turnbull, D. M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70116-2 · Cited by 315 · see citing works
Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming
Picard, M. A., Zhang, J., Hancock, S. A., Derbeneva, O. A., Golhar, R., Golik, P., O’Hearn, S. F., Levy, S., Potluri, P., Lvova, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414028111 · Cited by 311 · see citing works
Self-citationExtensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals
Ye, K., Lü, J., Ma, F., Keinan, A., & Gu, Z. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403521111 · Cited by 296 · see citing works
Vos, M. H. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00139 · Cited by 284 · see citing works
Gómez-Durán, A., Pacheu‐Grau, D., López‐Gallardo, E., Díez‐Sánchez, C., Montoya, J., López-Pérez, M. J., & Ruiz‐Pesini, E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq246 · Cited by 283 · see citing works
The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients
Taivassalo, T. (2003) · Brain · doi:10.1093/brain/awg028 · Cited by 282 · see citing works
Glucocorticoids and insulin resistance: old hormones, new targets
Andrews, R. C., & Walker, B. R. (1999) · Clinical Science · doi:10.1042/cs19980388 · Cited by 266 · see citing works
Molecular Signatures of Major Depression
Cai, N., Chang, S., Li, Y., Li, Q., Hu, J., Liang, J., Song, L., Kretzschmar, W. W., Gan, X., Nicod, J., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.008 · Cited by 264 · see citing works
Nasca, C., Xenos, D., Barone, Y., Caruso, A., Scaccianoce, S., Matrisciano, F., Battaglia, G., Mathé, A. A., Pittaluga, A., Lionetto, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216100110 · Cited by 264 · see citing works
Self-citationMotile axonal mitochondria contribute to the variability of presynaptic strength
Sun, T., Qiao, H., Pan, P.-Y., Chen, Y., & Sheng, Z.-H. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.040 · Cited by 263 · see citing works
Meimaridou, E., Kowalczyk, J., Guasti, L., Hughes, C. R., Wagner, F., Frommolt, P., Nürnberg, P., Mann, N. P., Banerjee, R., Saka, H. N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2299 · Cited by 259 · see citing works
Tyrka, A. R., Parade, S. H., Price, L. H., Kao, H.-T., Porton, B., Philip, N. S., Welch, E. S., & Carpenter, L. L. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.025 · Cited by 259 · see citing works
Catecholamine secretion as a function of perceived coping self-efficacy.
Bandura, A., & al., E. (1985) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.53.3.406 · Cited by 243 · see citing works
Hippocampal gene expression changes underlying stress sensitization and recovery
Gray, J. D., Rubin, T. G., Hunter, R. G., & McEwen, B. S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.175 · Cited by 242 · see citing works
Self-citationHara, Y., Yuk, F., Puri, R., Janssen, W. G. M., Rapp, P. R., & Morrison, J. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311310110 · Cited by 239 · see citing works
Reduced physical activity and risk of chronic disease: the biology behind the consequences
Booth, F. W., Laye, M. J., Lees, S. J., Rector, R. S., & Thyfault, J. P. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0606-5 · Cited by 239 · see citing works
Mouse mtDNA mutant model of Leber hereditary optic neuropathy
Lin, C. S., Sharpley, M. S., Fan, W., Waymire, K. G., Sadun, A. A., Carelli, V., Ross‐Cisneros, F. N., Baciu, P. C., Sung, E., McManus, M. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217113109 · Cited by 234 · see citing works
Self-citationMitochondria impact brain function and cognition
Picard, M. A., & McEwen, B. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321881111 · Cited by 230 · see citing works
Self-citationCatecholamine secretion as a function of perceived coping self-efficacy.
Bandura, A., Taylor, C. B., Williams, S. L., et al. (1985) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.53.3.406 · Cited by 223 · see citing works
Nasca, C., Bigio, B., Zelli, D., Nicoletti, F., & McEwen, B. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.96 · Cited by 194 · see citing works
Self-citationEpigenetic silencing mediates mitochondria stress-induced longevity
Schroeder, E. A., Raimundo, N., & Shadel, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.003 · Cited by 186 · see citing works
Differential Hypothalamic-Pituitary-Adrenal Axis Reactivity to Psychological and Physical Stress1
Singh, A. P., Petrides, J. S., Gold, P. W., Chrousos, G. P., & Deuster, P. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5746 · Cited by 176 · see citing works
Variability of Plasma Lipids in Response to Emotional Arousal
Dimsdale, J. E., & Herd, A. J. (1982) · Psychosomatic Medicine · doi:10.1097/00006842-198211000-00004 · Cited by 174 · see citing works
Nicholson, A. I., Reifsnyder, P. C., Malcolm, R. D., Lucas, C. A., MacGregor, G. R., Zhang, W., & Leiter, E. H. (2010) · Obesity · doi:10.1038/oby.2009.477 · Cited by 173 · see citing works
Hunter, R. G., Murakami, G., Dewell, S. B., Seligsohn, M., Baker, M. E. R., Datson, N. A., McEwen, B. S., & Pfaff, D. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215810109 · Cited by 173 · see citing works
Self-citationKado, S., Nagase, T., & Nagata, N. (1999) · Acta Diabetologica · doi:10.1007/s005920050147 · Cited by 158 · see citing works
Glucose but Not Protein or Fat Load Amplifies the Cortisol Response to Psychosocial Stress
Gonzalez-Bono, E., Rohleder, N., Hellhammer, D. H., Salvador, A., & Kirschbaum, C. (2002) · Hormones and Behavior · doi:10.1006/hbeh.2002.1766 · Cited by 127 · see citing works
Control of GABA release at single mossy fiber-CA3 connections in the developing hippocampus
Safiulina (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/neuro.19.001.2010 · Cited by 124 · see citing works
Fisher‐Wellman, K. H., Lin, C., RYAN, T. E., Reese, L., Gilliam, L. A. A., Cathey, B. L., Lark, D. S., Smith, C. D., Muoio, D. M., & Neufer, P. D. (2015) · Biochemical Journal · doi:10.1042/bj20141447 · Cited by 121 · see citing works
Mitochondria and the economy of stress (mal)adaptation
Morava, É., & Kozicz, T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.005 · Cited by 119 · see citing works
Linking the Metabolic State and Mitochondrial DNA in Chronic Disease, Health, and Aging
Picard, M. A., & Turnbull, D. M. (2013) · Diabetes · doi:10.2337/db12-1203 · Cited by 114 · see citing works
Self-citationSu, Y. A., Wu, J., Zhang, L., Zhang, Q., Su, D. M., He, P., Wang, B.-D., Li, H., Webster, M. J., Group, T. S. B. S., et al. (2008) · International Journal of Biological Sciences · doi:10.7150/ijbs.4.223 · Cited by 113 · see citing works
Strauss, K. A., DuBiner, L., Simon, M. T., Zaragoza, M. V., Sengupta, P. P., Li, P., Narula, N., Dreike, S., Platt, J., Procaccio, V., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300690110 · Cited by 103 · see citing works
Self-citationDefective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice
Fergusson, G., Éthier, M., Guévremont, M., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.09.006 · Cited by 99 · see citing works
Juster, R.-P., Perna, A., Marin, M.-F., Sindi, S., & Lupien, S. J. (2012) · Stress · doi:10.3109/10253890.2012.661494 · Cited by 96 · see citing works
Effect of psychological stress on glucose control in patients with Type 2 diabetes
Faulenbach, M., Uthoff, H., Schwegler, K., Spinas, G. A., Schmid, C., & Wiesli, P. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03431.x · Cited by 96 · see citing works
An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA
Acín‐Pérez, R. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg021 · Cited by 78 · see citing works
Characterization of N-ethoxycarbonyl ethyl esters of amino acids by mass spectrometry
Huang, Z.-H., Jian, W., Gage, D. A., et al. (1993) · Journal of Chromatography A · doi:10.1016/0021-9673(93)80370-n · Cited by 78 · see citing works
Differential Hypothalamic-Pituitary-Adrenal Axis Reactivity to Psychological and Physical Stress
Singh, A. K. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1944 · Cited by 74 · see citing works
Olsen, R. H. J., Johnson, L. A., Zuloaga, D. G., Limoli, C. L., & Raber, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12187 · Cited by 72 · see citing works
Sindi, S., Fiocco, A. J., Juster, R., Pruessner, J. C., & LUPIEN, S. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.004 · Cited by 67 · see citing works
New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation
Pelletier, M., Lepow, T. S., Billingham, L. K., Murphy, M. P., & Siegel, R. M. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2013.01.002 · Cited by 64 · see citing works
Racial and Ethnic Differences in Diurnal Cortisol Rhythms
DeSantis, A. S., Adam, E. K., Hawkley, L. C., Kudielka, B. M., & Cacioppo, J. T. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000131 · Cited by 63 · see citing works
van de Merbel, N. C., Hendriks, G., Imbos, R., et al. (2011) · Bioanalysis · doi:10.4155/bio.11.170 · Cited by 57 · see citing works
Nissim, I., Horyn, O., Nissim, I. B., Daikhin, Y., Wehrli, S. L., Yudkoff, M., & Matschinsky, F. M. (2012) · Biochemical Journal · doi:10.1042/bj20120163 · Cited by 46 · see citing works
Knapman, A., Kaltwasser, S. F., Martins‐de‐Souza, D., Holsboer, F., Landgraf, R., Turck, C. W., Czisch, M., & Touma, C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07968.x · Cited by 44 · see citing works
Armbruster, D., Mueller‐Alcazar, A., Strobel, A., Lesch, K., Brocke, B., & Kirschbaum, C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.03.010 · Cited by 42 · see citing works
Behavior and Stress Reactivity in Mouse Strains with Mitochondrial DNA Variations
Gimsa, U., Kanitz, E., Otten, W., & Ibrahim, S. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03960.x · Cited by 39 · see citing works
ACTH Resistance: Genes and Mechanisms
Meimaridou, E., Hughes, C. R., Kowalczyk, J., Chan, L. F., Clark, A., & Metherell, L. (2013) · Endocrine development · doi:10.1159/000342504 · Cited by 39 · see citing works
Biomarkers Identified in Inborn Errors for Lysine, Arginine, and Ornithine
Saudubray, J., & Rabier, D. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1669s · Cited by 37 · see citing works
Lactate metabolism during exercise in patients with mitochondrial myopathy
Jeppesen, T. D., Ørngreen, M. C., van Hall, G., & Vissing, J. (2013) · Neuromuscular Disorders · doi:10.1016/j.nmd.2013.05.007 · Cited by 31 · see citing works
The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse
Arkblad, E. L., Betsholtz, C., & Rydström, J. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(95)00159-x · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Weiner H (1992) Perturbing the Organism: The Biology of Stressful Life Experience (Univ of Chicago Press, Chicago).
Cited by
Sorted by citations
Sies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045037 · Cited by 3,520 · see citing works
Lindqvist, D., Wolkowitz, O. M., Picard, M., Ohlsson, L., Bersani, F. S., Fernström, J., Westrin, Å., Hough, C. M., Lin, J., Reus, V. I., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-017-0001-9 · Cited by 188 · see citing works
Self-citationRedefining neuroendocrinology: Epigenetics of brain-body communication over the life course
McEwen, B. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.11.001 · Cited by 129 · see citing works
Self-citationAdrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies
Midzak, A., & Papadopoulos, V. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00106 · Cited by 114 · see citing works
“Although mitochondrial energetics have traditionally served an ancillary role in steroidogenic research (16), the recent finding that mitochondrial function directly impacts neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress (17) prompts a brief review.”
BackgroundChronic Stress and Diabetes Mellitus: Interwoven Pathologies
Sharma, V. K., & Singh, T. G. (2020) · Current Diabetes Reviews · doi:10.2174/1573399815666191111152248 · Cited by 116 · see citing works
Allostasis, action and affect in depression: Insights from the theory of constructed emotion
Shaffer, C., Westlin, C., Quigley, K. S., Whitfield-Gabrieli, S., & Barrett, L. F. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-115627 · Cited by 94 · see citing works
Slattery, J., MacFabe, D., Kahler, S., & Frye, R. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160905123953 · Cited by 20 · see citing works
- Authors
- Picard, M., McManus, M. J., Gray, J. D., Nasca, C., Moffat, C., Kopinski, P. K., Seifert, E. L., McEwen, B. S., & Wallace, D. C.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Rockefeller University (US)
- Thomas Jefferson University (US)
- Corresponding author
- Wallace, Douglas C.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-11-16
- Volume
- 112
- Issue
- 48
- Pages
- E6614-23
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4672794
- OpenAlex
- W2181244039
- Cited by
- 293
- References
- 87
- Citations by year
- 2026: 27 · 2025: 28 · 2024: 33 · 2023: 28 · 2022: 23 · 2021: 30 · 2020: 19 · 2019: 35 · 2018: 31 · 2017: 24 · 2016: 15
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CIHR (1)
- AHA (SDG14380008)
- NIH (MH41256, R01-NS21328, R01-DK73691, R01-CA143351)
- Hope for depression research Foundation (1)
- American Foundation for Suicide Prevention (1)
- NRSA (F32-MH102065)
- Simon Foundation (205844)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- mitochondrial dysfunction, acute psychological stress, restraint stress, hypothalamic-pituitary-adrenal axis, catecholamines, inflammatory cytokines, interleukin-6, mitochondrial redox balance, mitochondrial bioenergetics, mitochondrial respiratory chain, cytochrome c oxidase subunit I, ANT1, nicotinamide nucleotide transhydrogenase, hippocampal gene expression, stress response, mitochondrial disease
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Catecholamines, Electron Transport Complex IV, DNA, Mitochondrial, Gene Expression Regulation, Genotype, Hippocampus, Inflammation, Male, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Mutation, NADH Dehydrogenase, Stress, Psychological, Transcription, Genetic, Signal Transduction, Interleukin-6, Oxidative Stress, Mitochondrial Proteins, Adenine Nucleotide Translocator 1, Mice, Allostasis, NADP Transhydrogenase, AB-Specific
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
