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Cited by 235

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Thymic stromal lymphopoietin

Open access
He, Rui, Geha, Raif S.·2010·Annals of the New York Academy of Sciences

Abstract

Thymic stromal lymphopoietin (TSLP) is an epithelial cell‐derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via a TSLP receptor (TSLPR), a heterodimer of the IL‐7 receptor α chain and the TSLPR chain. The TSLPR chain is closely related to the common receptor γ chain that is expressed on a wide range of cell types in the adaptive and innate immune system. TSLP exerts a profound influence on the polarization of dendritic cells to drive T helper (Th) 2 cytokine production. TSLP also directly promotes T‐cell proliferation in response to T‐cell receptor activation and Th2 cytokine production and supports B‐cell expansion and differentiation. TSLP further amplifies Th2 cytokine production by mast cells and natural killer T cells. These properties confer on TSLP a critical role in driving Th2‐mediated inflammation. This role is supported by the finding that TSLP expression is upregulated in keratinocytes of atopic dermatitis skin lesions and in bronchial epithelial cells in asthma.

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Crossref · 10.1111/j.1749-6632.2009.05128.x

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Metadata

Authors
He, R., & Geha, R. S.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2010-01
Volume
1183
Issue
1
Pages
13-24
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1824222084
Cited by
235
References
2
FWCI
26.49
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Thymic stromal lymphopoietin. https://app.cochat.ai/papers/10.1111/j.1749-6632.2009.05128.x
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He, R., & Geha, R. S. (2010). Thymic stromal lymphopoietin. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2009.05128.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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