The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites
Open accessAbstract
Summary: There is compelling evidence that epithelial cells (ECs) at mucosal surfaces, beyond their role in creating a physical barrier, are integral components of innate and adaptive immunity. The capacity of these cells to license the functions of specific immune cell populations in the airway and gastrointestinal tract offers the prospect of novel therapeutic strategies to target multiple inflammatory diseases in which barrier immunity is dysregulated. In this review, we discuss the critical functions of EC‐derived thymic stromal lymphopoietin (TSLP), interleukin‐25 (IL‐25), and IL‐33 in the development and regulation of T‐helper 2 (Th2) cytokine‐dependent immune responses. We first highlight recent data that have provided new insights into the factors that control expression of this triad of cytokines and their receptors. In addition, we review their proinflammatory and immunoregulatory functions in models of mucosal infection and inflammation. Lastly, we discuss new findings indicating that despite their diverse structural features and differential expression of their receptors, TSLP, IL‐25, and IL‐33 cross‐regulate one another and share overlapping properties that influence Th2 cytokine‐dependent responses at mucosal sites.
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Cites
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Self-citationIL-25 regulates Th17 function in autoimmune inflammation
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“176 r 2008 The Authors Journal compilation r 2008 Blackwell Munksgaard Immunological Reviews 226/2008 IL-25-IL-17Rb signaling While TSLPR exhibits a broad distribution pattern, the receptor for IL-25 (IL-17Rb) is more restricted.”
BackgroundInfluential
Cited by
Control of adaptive immunity by the innate immune system
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Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
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Barrier Epithelial Cells and the Control of Type 2 Immunity
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Metadata
- Authors
- Saenz, S. A., Taylor, B. C., & Artis, D.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2008-10-30
- Volume
- 226
- Issue
- 1
- Pages
- 172-190
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2050706371
- Cited by
- 484
- References
- 12
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Saenz, S. A., Taylor, B. C., & Artis, D. (2008). Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.2008.00713.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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