Low‐dose glucocorticoid therapy in rheumatoid arthritis: an obligatory therapy
Abstract
Glucocorticoids (GCs) are used extensively in patients with rheumatoid arthritis (RA). Recent data on the efficacy of these drugs in alleviating symptoms of inflammation, but also in retarding erosive damage, are presented. In addition, a critical review of the rather limited literature on adverse effects of chronic use of low dose GCs is given. It becomes clear that the net effect of low‐dose GCs in the treatment of rheumatoid arthritis favors the beneficial aspects of these drugs above the negative aspects. Prudent use of GCs can be recommended.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glucocorticoids are the cornerstone in the treatment of numerous chronic autoimmune and inflammatory diseases, including rheumatoid arthritis, polymyalgia rheumatica, giant cell arteritis, systemic lupus erythematosus and inflammatory bowel diseases.
“Glucocorticoids (GCs) are the cornerstone in the treatment of numerous chronic autoimmune and inflammatory diseases, including rheumatoid arthritis [1], polymyalgia rheumatica [2] and giant cell arteritis [3], systemic lupus erythematosus [4] and inflammatory bowel diseases [5].”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [1]
The efficacy of low-dose GCs (≤7.5 mg prednisolone equivalent daily) on disease activity in various conditions is well established.
“Although the efficacy of these doses on disease activity in various conditions is well established [1–4, 7]”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [1]
Cites
Boers, M., Verhoeven, A. C., Markusse, H. M., van de Laar, M. A., Westhovens, R., van Denderen, J. C., van Zeben, D., Dijkmans, B. A. C., Peeters, A. J., Jacobs, P., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01300-7 · Cited by 1,073 · see citing works
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis
Kirwan, J. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507203330302 · Cited by 817 · see citing works
Self-citationLandewé, R., Boers, M., Verhoeven, A. C., Westhovens, R., van de Laar, M. A. F. J., Markusse, H. M., van Denderen, J. C., Westedt, M. L., Peeters, A. J., Dijkmans, B. A. C., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10083 · Cited by 611 · see citing works
da Silva, J. A. P., Jacobs, J. W. G., Kirwan, J., Boers, M., Saag, K. G., Inês, L. B. S., de Koning, E. J. P., Buttgereit, F., Cutolo, M., Capell, H., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.038638 · Cited by 522 · see citing works
Self-citationvan Everdingen, A. A., Jacobs, J. W. G., van Reesema, D. R. S., & Bijlsma, J. W. J. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-1-200201010-00006 · Cited by 488 · see citing works
Self-citationHoes, J. N., Jacobs, J. W. G., Boers, M., Boumpas, D., Buttgereit, F., Caeyers, N., Choy, E., Cutolo, M., da Silva, J. A. P., Esselens, G., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.072157 · Cited by 410 · see citing works
Self-citationTreating rheumatoid arthritis early: A window of opportunity?
O’Dell, J. R. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10092 · Cited by 268 · see citing works
Adverse events of low- to medium-dose oral glucocorticoids in inflammatory diseases: a meta-analysis
Hoes, J. N., Jacobs, J. W. G., Verstappen, S. M. M., Bijlsma, J. W. J., & Van der Heijden, G. J. M. G. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.100008 · Cited by 243 · see citing works
Self-citationCapell, H. A., Madhok, R., Hunter, J. A., Porter, D., Morrison, E., Larkin, J., Thomson, E. A., Hampson, R., & Poon, F. W. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.014050 · Cited by 158 · see citing works
Gøtzsche, P. C., & Johansen, H. K. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000189.pub2 · Cited by 99 · see citing works
Hansen, M., Pødenphant, J., Florescu, A., et al. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.11.713 · Cited by 96 · see citing works
Hafström, I., Albertsson, K., Boonen, A. E. R. C. H., van der Heijde, D. M. F. M., Landewé, R., & Svensson, B. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.087833 · Cited by 85 · see citing works
Jacobs, J. W. G., van Everdingen, A. A., Verstappen, S. M. M., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21809 · Cited by 83 · see citing works
Self-citationModerate-term, low-dose corticosteroids for rheumatoid arthritis
Criswell, L. A., Saag, K. G., Sems, K. M., Welch, V. A., Shea, B., Wells, G. A., & Suarez-Almazor, M. E. (1998) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001158 · Cited by 73 · see citing works
Paulus, H. E., Primeo, D. D., Sanda, M., et al. (2000) · PubMed · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Senescent Cells and Their Secretory Phenotype as Targets for Cancer Therapy
Velarde, M. C., Demaria, M., & Campisi, J. (2013) · Interdisciplinary Topics in Gerontology and Geriatrics · doi:10.1159/000343572 · Cited by 112 · see citing works
van Raalte, D. H., Brands, M., van der Zijl, N. J., Muskiet, M. H., Pouwels, P. J. W., Ackermans, M. T., Sauerwein, H. P., Serlie, M. J., & Diamant, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2174-9 · Cited by 109 · see citing works
“Although the efficacy of these doses on disease activity in various conditions is wellestablished [1-4;7], the extent to which these low dosages induce adverse metabolic effects is unclear.”
Background
- Authors
- Bijlsma, J. W. J., van der Goes, M. C., Hoes, J. N., Jacobs, J. W. G., Buttgereit, F., & Kirwan, J.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Bijlsma, Johannes W.J.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 1193
- Issue
- 1
- Pages
- 123-126
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1490413998
- Cited by
- 31
- References
- 15
- Citations by year
- 2024: 2 · 2023: 1 · 2020: 2 · 2017: 1 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- low-dose glucocorticoids, rheumatoid arthritis, glucocorticoid therapy, glucocorticoid adverse effects, anti-inflammatory efficacy
- MeSH terms
- Arthritis, Rheumatoid, Dose-Response Relationship, Drug, Glucocorticoids, Humans, Randomized Controlled Trials as Topic, Practice Guidelines as Topic, Antirheumatic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
