Metformin in polycystic ovary syndrome
Abstract
Polycystic ovary syndrome (PCOS) affects 6.6–6.8% of women in reproductive age. Insulin resistance and hyperinsulinemia play a critical role in the pathogenesis of PCOS and are associated with a high risk for type 2 diabetes mellitus and cardiometabolic abnormalities. Metformin has been introduced as a therapeutic option in PCOS, targeting of cardiometabolic and reproductive abnormalities on the basis of its action on the reduction of glucose levels and the attenuation of insulin resistance. The tissue‐specific actions of metformin as well as the molecular mechanisms involved in the liver, the muscle, the endothelium, and the ovary are elucidated in this review. The use of metformin in pregnant women with PCOS is another of its positive features. Overall, available data supports the therapeutic usefulness of metformin on cardiometabolic risk and reproduction assistance in PCOS women.
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Obesity, insulin resistance with compensatory hyperinsulinemia, and low-grade chronic inflammatory status often coexist with PCOS.
“Beyond hormonal derangements, obesity, insulin-resistance (IR), with associated compensatory hyperinsulinemia [5], and a low-grade chronic inflammatory status often coexist with PCOS [6].”
From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [5]
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- Authors
- Diamanti‐Kandarakis, E., Economou, F., Palimeri, S., & Christakou, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Diamanti‐Kandarakis, Evanthia
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-09
- Volume
- 1205
- Issue
- 1
- Pages
- 192-198
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2127037921
- Cited by
- 109
- References
- 4
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 12
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- metformin, polycystic ovary syndrome, insulin resistance, hyperinsulinemia, type 2 diabetes, cardiometabolic risk, reproductive outcomes, ovary
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Hypoglycemic Agents, Infertility, Female, Metabolic Diseases, Metformin, Polycystic Ovary Syndrome, Pregnancy
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