Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients
Open accessAbstract
Objective We aim to assess the effect of metformin treatment on metabolic parameters, endothelial function and inflammatory markers in polycystic ovary syndrome (PCOS) subjects.Methods The study population consisted of 40 reproductive-age women with PCOS, who underwent treatment with metformin during a 12-week period, and their corresponding matched controls (n = 44). We evaluated endocrinological parameters, adhesion molecules (vascular cell adhesion molecule 1 (VCAM-1), intercellular cell adhesion molecule 1 (ICAM-1) and E-selectin) and proinflammatory cytokines (interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα)) in serum. In addition, interactions between human umbilical vein endothelial cells and polymorphonuclear (PMN) cells were assessed by flow chamber microscopy. In addition, a group of type 2 diabetes patients who underwent treatment with metformin during a 12-week period was incorporated into the study.Results Metformin produced beneficial effects on PCOS patients by decreasing polymorphonuclear (PMN) rolling flux and adhesion. It also decreased levels of ICAM-1, E-selectin, IL-6 and ΤΝFα. In addition, metformin induced an improvement of endocrine and anthropometric parameters in PCOS subjects by reducing glucose, follicle-stimulating hormone (FSH) and androstendione, and by increasing dehydroepiandrosterone-sulfate (DHEA-S). Metformin also had beneficial effects in type 2 diabetic subjects by reducing body weight, waist circumference and PMN adhesion, and by increasing PMN rolling velocity.Conclusion Our results highlight the modulating effect of metformin on leukocyte/endothelium interactions. These findings may explain the potential beneficial effect of metformin in reducing the risk of vascular events in PCOS patients and in insulin resistance conditions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Metformin has additional benefit for conditions like polycystic ovary syndrome, atherosclerosis, cancer, COVID-19, and obesity.
“Aside from its anti-hyperglycemic effects, metformin has an additional benefit for conditions like polycystic ovary syndrome, atherosclerosis, cancer, coronavirus disease 2019 (COVID-19), and obesity (7–14).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [11]
Cites
1 retracted
Shaw, L. J., Bairey Merz, C. N., Azziz, R., Stanczyk, F. Z., Sopko, G., Braunstein, G. D., Kelsey, S. F., Kip, K. E., Cooper-DeHoff, R. M., Johnson, B. D., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0425 · Cited by 427 · see citing works
Retracted(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
Standards of medical care in diabetes—2013
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369 · see citing works
Role of Endothelial Dysfunction in Atherosclerosis
Davignon, J., & Ganz, P. (2004) · Circulation · doi:10.1161/01.cir.0000131515.03336.f8 · Cited by 2,513 · see citing works
Leukocyte-endothelial adhesion molecules
Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.bloodjournal8472068 · Cited by 2,500 · see citing works
Standards of Medical Care in Diabetes—2012
(2012) · Diabetes Care · doi:10.2337/dc12-s011 · Cited by 2,240 · see citing works
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219 · see citing works
Leukocyte-endothelial adhesion molecules
Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.2068 · Cited by 1,957 · see citing works
Androgen Excess in Women: Experience with Over 1000 Consecutive Patients
Azziz, R., Sanchez, L. A., Knochenhauer, E. S., Moran, C., Lazenby, J., Stephens, K. C., Taylor, K., & Boots, L. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031122 · Cited by 1,132 · see citing works
Data analysis 2Preprint
Wagemans, F. M. A., Brandt, M. J., & Zeelenberg, M. (2016) · Cited by 952 · see citing works
Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus
Meigs, J. B. (2004) · JAMA · doi:10.1001/jama.291.16.1978 · Cited by 643 · see citing works
Coronary Heart Disease Risk Factors in Women With Polycystic Ovary Syndrome
Talbott, E. O., Guzick, D. S., Clerici, A., Berga, S. L., Detre, K. M., Weimer, K., & Kuller, L. H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.821 · Cited by 499 · see citing works
Hattori, Y., Suzuki, K., Hattori, S., & Kasai, K. (2006) · Hypertension · doi:10.1161/01.hyp.0000221429.94591.72 · Cited by 487 · see citing works
Polycystic Ovary Syndrome Is Associated With Endothelial Dysfunction
Paradisi, G., Steinberg, H. O., Hempfling, A., Cronin, J., Brechtel, G., Shepard, M. K., & Baron, A. (2001) · Circulation · doi:10.1161/01.cir.103.10.1410 · Cited by 476 · see citing works
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1696 · Cited by 459 · see citing works
Calvert, J. W., Gundewar, S., Jha, S., Greer, J. J. M., Bestermann, W. H., Tian, R., & Lefer, D. J. (2008) · Diabetes · doi:10.2337/db07-1098 · Cited by 422 · see citing works
Adhesion molecules and their role in vascular disease
Krieglstein, C. F. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02069-6 · Cited by 352 · see citing works
Orio, F., Palomba, S., Cascella, T., Simone, B. D., Biase, S. D., Russo, T., Labella, D., Zullo, F., Lombardi, G., & Colao, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031867 · Cited by 330 · see citing works
Prognostic Role of Flow-Mediated Dilation and Cardiac Risk Factors in Post-Menopausal Women
Rossi, R., Nuzzo, A., Origliani, G., & Modena, M. G. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.044 · Cited by 277 · see citing works
Orio, F., Palomba, S., Spinelli, L., Cascella, T., Tauchmanovà, L., Zullo, F., Lombardi, G., & Colao, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032049 · Cited by 275 · see citing works
Diamanti‐Kandarakis, E., Paterakis, T., Alexandraki, K., Piperi, C., Aessopos, A., Katsikis, I., Katsilambros, N. L., Kreatsas, G., & Panidis, D. (2006) · Human Reproduction · doi:10.1093/humrep/del003 · Cited by 258 · see citing works
Diamanti‐Kandarakis, E., Christakou, C. D., Kandaraki, E., & Economou, F. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0733 · Cited by 246 · see citing works
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2327 · Cited by 228 · see citing works
Ortega-González, C., Luna, S. L., Hernández, L., Crespo, G., Aguayo, P., Arteaga‐Troncoso, G., & Parra, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1965 · Cited by 211 · see citing works
Predictors of Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome
Kravariti, M., Naka, K. Κ., Kalantaridou, S., Kazakos, N., Katsouras, C. S., Makrigiannakis, A., Paraskevaidis, E. A., Chrousos, G. P., Tsatsoulis, A. A., & Michalis, L. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0151 · Cited by 188 · see citing works
Metformin administration improves endothelial function in women with polycystic ovary syndrome
Diamanti‐Kandarakis, E., Alexandraki, K., Protogerou, A. D., Piperi, C., Papamichael, C. M., Aessopos, A., Lekakis, J., & Mavrikakis, M. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01910 · Cited by 179 · see citing works
Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S., Dunseath, G., Ludgate, M., & Rees, D. (2009) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2009-1985 · Cited by 170 · see citing works
Meyer, C., McGrath, B. P., & Teede, H. J. (2007) · Diabetes Care · doi:10.2337/dc06-0618 · Cited by 148 · see citing works
Víctor, V. M., Rocha, M., Bañuls, C., Álvarez, Á., de Pablo, C., Sánchez-Serrano, M., Gomez, M., & Hernández‐Mijares, A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0651 · Cited by 132 · see citing works
Self-citationVíctor, V. M., Rocha, M., Bañuls, C., Sánchez-Serrano, M., Solá, E., Gomez, M., & Hernández‐Mijares, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0466 · Cited by 119 · see citing works
Self-citationCardiovascular Risk In Women With Polycystic Ovary Syndrome
Talbott, E. O., Zborowski, J. V., Sutton-Tyrrell, K., McHugh-Pemu, K. P., & Guzick, D. S. (2001) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70189-3 · Cited by 113 · see citing works
Metformin in polycystic ovary syndrome
Diamanti‐Kandarakis, E., Economou, F., Palimeri, S., & Christakou, C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05679.x · Cited by 109 · see citing works
Rajendran, S., Willoughby, S. R., Chan, W. P. A., Liberts, E. A., Heresztyn, T., Saha, M., Marber, M. S., Norman, R. J., & Horowitz, J. D. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.09.010 · Cited by 104 · see citing works
Jude, E. B., Douglas, J. T., Anderson, S. G., Young, M. J., & Boulton, A. J. M. (2002) · European Journal of Internal Medicine · doi:10.1016/s0953-6205(02)00014-6 · Cited by 94 · see citing works
Naka, K. Κ., Kalantaridou, S., Kravariti, M., Bechlioulis, A., Kazakos, N., Calis, K. A., Makrigiannakis, A., Katsouras, C. S., Chrousos, G. P., Tsatsoulis, A. A., et al. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.06.058 · Cited by 79 · see citing works
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06579 · Cited by 75 · see citing works
Diamanti‐Kandarakis, E., Alexandraki, K., Piperi, C., Aessopos, A., Paterakis, T., Katsikis, I., & Panidis, D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.09.006 · Cited by 75 · see citing works
Hernández‐Mijares, A., Rocha, M., Rovira‐Llopis, S., Bañuls, C., Bellod, L., de Pablo, C., Álvarez, Á., Torres, I. R., Solá-Izquierdo, E., & Víctor, V. M. (2013) · Diabetes Care · doi:10.2337/dc12-1224 · Cited by 72 · see citing works
Self-citationRovira‐Llopis, S., Rocha, M., Falcón, R., de Pablo, C., Álvarez, Á., Jover, A., Hernández‐Mijares, A., & Víctor, V. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5307 · Cited by 65 · see citing works
Self-citationLong-term consequences of polycystic ovary syndrome on cardiovascular risk
Rizzo, M., Berneis, K. K., Spinas, G. A., Rini, G. B., & Carmina, E. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.070 · Cited by 61 · see citing works
Özgürtaş, T., Öktenli, Ç., Dede, M., Tapan, S., Kenar, L., Sanisoğlu, S. Y., Yeşilova, Z., Yenen, M. C., Erbil, M. K., & Başer, İ. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.054 · Cited by 38 · see citing works
Cardiometabolic abnormalities in the polycystic ovary syndrome: Pharmacotherapeutic insights
Westerveld, H. E., Hoogendoorn, M., de Jong, A. W. F., Goverde, A. J., Fauser, B. C. J. M., & Dallinga‐Thie, G. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.04.009 · Cited by 38 · see citing works
Liu, Y., Huang, C., Ceng, C., Zhan, H., Zheng, D., & Han, W. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-115 · Cited by 34 · see citing works
Bilgir, O., Kebapçılar, L., Taner, C. E., Bilgir, F., Kebapçılar, A. G., Bozkaya, G., Yıldız, Y., Yüksel, A., & Sarı, İ. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.2177 · Cited by 31 · see citing works
Leukocyte trafficking in primary immunodeficiencies
Notarangelo, L. D., & Badolato, R. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0808474 · Cited by 30 · see citing works
Topçu, S., Tok, D., Çalışkan, M., Özçimen, E. E., Güllü, H., Üçkuyu, A., Erdoğan, D., Zeyneloğlu, H. B., & Müderrisoğlu, H. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02551.x · Cited by 27 · see citing works
Pablo, C. D., Orden, S., Peris, J., Barrachina, M. D., Esplugues, J. V., & Álvarez, Á. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit340 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works
Metformin treatment status and abdominal aortic aneurysm disease progression
Fujimura, N., Xiong, J., Kettler, E. B., Xuan, H., Glover, K. J., Mell, M. W., Xu, B., & Dalman, R. L. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.02.020 · Cited by 163 · see citing works
Itoga, N. K., Rothenberg, K. A., Suarez, P., Ho, V. T., Mell, M. W., Xu, B., Curtin, C. M., & Dalman, R. L. (2018) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2018.06.194 · Cited by 130 · see citing works
Rovira‐Llopis, S., Bañuls, C., Marañón, A., Díaz‐Morales, N., Jover, A., Garzón, S., Rocha, M., Víctor, V. M., & Hernández‐Mijares, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.03.029 · Cited by 122 · see citing works
Self-citationGao, L., Gu, Y., & Yin, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164021 · Cited by 95 · see citing works
Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome
Zhang, Y., Hu, M., Meng, F., Sun, X., Xu, H., Zhang, J., Cui, P., Morina, N., Li, X., Li, W., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.023 · Cited by 90 · see citing works
The Fatty Acid Lipid Metabolism Nexus in COVID-19
Tanner, J. E., & Alfieri, C. (2021) · Viruses · doi:10.3390/v13010090 · Cited by 87 · see citing works
Valencia, I., Lumpuy‐Castillo, J., Magalhães, G. S., Sánchez‐Ferrer, C. F., Lorenzo, Ó., & Peiró, C. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02097-8 · Cited by 78 · see citing works
Planas, D., Pagliuzza, A., Ponte, R., Fert, A., Marchand, L. R., Massanella, M., Gosselin, A., Mehraj, V., Dupuy, F. P., Isnard, S., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103270 · Cited by 68 · see citing works
Kim, H.-S., Ren, G., Kim, T., Bhatnagar, S., Yang, Q., Bahk, Y. Y., & Kim, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70347-w · Cited by 66 · see citing works
Metformin-induced anticancer activities: recent insights
Safe, S. H., Nair, V., & Karki, K. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0271 · Cited by 61 · see citing works
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang, J., Isnard, S., Lin, J. C.-Y., Fombuena, B., Marette, A., Routy, B., Chen, Y., & Routy, J. (2020) · AIDS Research and Therapy · doi:10.1186/s12981-020-00267-2 · Cited by 58 · see citing works
Bułdak, Ł., Machnik, G., Bułdak, R. J., Łabuzek, K., Bołdys, A., & Okopień, B. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1277-8 · Cited by 53 · see citing works
Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota
Isnard, S., Lin, J., Fombuena, B., Ouyang, J., Varin, T. V., Richard, C., Marette, A., Ramendra, R., Planas, D., Raymond Marchand, L., et al. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa338 · Cited by 51 · see citing works
Li, D. X., Yang, S., Xing, Y., Pan, L., Zhao, R., Zhao, Y., Liu, L., & Wu, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673839 · Cited by 48 · see citing works
Routy, J., Isnard, S., Mehraj, V., Ostrowski, M., Chomont, N., Ancuța, P., Ponte, R., Planas, D., Dupuy, F. P., & Angel, J. B. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028444 · Cited by 45 · see citing works
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin
Ouyang, J., Isnard, S., Lin, J., Fombuena, B., Peng, X., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.581839 · Cited by 39 · see citing works
Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations
Ferreira, S. R., & Motta, A. B. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171205144119 · Cited by 36 · see citing works
Endothelial maintenance in health and disease: Importance of sex differences
Mudrovcic, N., Arefin, S., Craenenbroeck, A. H. V., & Kublickiene, K. R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.011 · Cited by 34 · see citing works
Pereira, C. A., Carneiro, F. S., Matsumoto, T., & Tostes, R. C. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13054 · Cited by 34 · see citing works
Sun, J., Huang, N., Ma, W., Zhou, H., & Lai, K. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9807 · Cited by 34 · see citing works
Allende-Vega, N., Marco-Brualla, J., Falvo, P., Alexia, C., Constantinides, M., de Maudave, A. F., Coënon, L., Gitenay, D., Mitola, G., Massa, P. E., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05470-x · Cited by 30 · see citing works
Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020) · Endocrine Connections · doi:10.1530/ec-20-0173 · Cited by 24 · see citing works
Zhang, B., Guo, X., Li, Y., Peng, Q., Gao, J., Liu, B., & Wang, M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600710 · Cited by 24 · see citing works
Dube, R. (2016) · Avicenna Journal of Medicine · doi:10.4103/2231-0770.191445 · Cited by 17 · see citing works
Metformin in gynecological disorders: pathogenic insights and therapeutic implications
Nie, P., Wang, M., Mo, Y., Zhou, H., Zha, Q., Lash, G. E., & Li, P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1526709 · Cited by 15 · see citing works
Zaongo, S. D., & Chen, Y. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002493 · Cited by 8 · see citing works
Patel, M., Battarbee, A. N., Refuerzo, J., Zork, N. M., Eichelberger, K. Y., Ramos, G. A., Olson, G., Durnwald, C. P., Landon, M. B., Aagaard, K. M., et al. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005720 · Cited by 7 · see citing works
Background and Proposed Design for a Metformin Abdominal Aortic Aneurysm Suppression Trial
Dalman, R. L., Lü, Y., Mahaffey, K. W., Chase, A. J., Stern, J. R., & Chang, R. W. (2020) · Vascular and Endovascular Review · doi:10.15420/ver.2020.03 · Cited by 6 · see citing works
Metformin Exposure and Risk of Hypertensive Disorders of Pregnancy in Patients with Type 2 Diabetes
Racine, J. L., Adams, J. H., Antony, K. M., Hoppe, K. K., Iruretagoyena, J. I., Stewart, K. S., Eddy, A., & Rhoades, J. S. (2021) · American Journal of Perinatology · doi:10.1055/s-0041-1728821 · Cited by 5 · see citing works
Ullah, A., Chen, Y., Zhang, F., & Shen, B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1749906 · Cited by 4 · see citing works
Matossian, G. A., Buklarewicz, I. M., & Moosa, V. A. (2023) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.483 · Cited by 3 · see citing works
Harmon, D. C., Levene, J., Rutlen, C., White, E. S., Freeman, I., & Lapidus, J. (2024) · Journal of General Internal Medicine · doi:10.1007/s11606-024-08864-x · Cited by 3 · see citing works
Vieira, H. R., Gonçalves, G. D., Alves, V. S., Melo, M. A. B., Borges, S. C., Klagenberg, J., Neves, C. Q., Previate, C., Saavedra, L. P. J., Siervo, G. E. M. D. L., et al. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115712 · Cited by 3 · see citing works
Ugwueze, C. V. (2025) · Journal of Diabetology · doi:10.4103/jod.jod_101_24 · Cited by 3 · see citing works
Allende-Vega, N., Marco-Brualla, J., Falvo, P., Alexia, C., Constantinides, M., de Maudave, A. F., Coënon, L., Gitenay, D., Mitola, G., Massa, P. E., et al. (2021) · Preprints.org · doi:10.20944/preprints202107.0484.v1 · Cited by 2 · see citing works
Effect of current antidiabetic drugs on inflammation and immune system
Karoli, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13195-0.00015-6 · Cited by 1 · see citing works
Metformin Reduces Inflammatory Markers Through AMPK Activation in Type 2 Diabetes Patients
Al-din, K. H. S. S. (2025) · Academia Open · doi:10.21070/acopen.10.2025.13015 · Cited by 1 · see citing works
Javed, Z. (2018) · Repository@Hull (Worktribe) (University of Hull)
Dynamics of soluble selectins during of therapy of non-alcoholic fatty liver disease
Yagoda, A., Koroy, P., Kravchenko, Y. A., & Sarithala, V. J. (2022) · Medical news of the North Caucasus · doi:10.14300/mnnc.2022.17029
Immunologische Veränderungen beim Syndrom polyzystischer Ovarien
Bazzano, M. V., Köninger, A., & Solano, M. E. (2023) · Gynäkologische Endokrinologie · doi:10.1007/s10304-023-00532-3
OS EFEITOS DA METFORMINA NO TRATAMENTO DA SÍNDROME DO OVÁRIO POLICÍSTICO
Gonçalves, M. A. R. (2024) · Revista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida · doi:10.36692/v16n2-125r
Nimesulide with Metformin Lowers Inflammatory Markers in Women with PCOS
Qasim, R. M., AL-Rikabi, M. A., & Khosho, E. Z. (2025) · Academia Open · doi:10.21070/acopen.10.2025.12843
- Authors
- Victor, V. M., Rovira-Llopis, S., Bañuls, C., Diaz-Morales, N., Lopez-Domenech, S., Escribano-López, I., Rios-Navarro, C., Alvarez, A., Gomez, M., Rocha, M., & Hernandez-Mijares, A.
- Affiliations
- Universitat de València (ES)
- Corresponding author
- Rocha, Milagros
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 242
- Issue
- 1
- Pages
- 167-173
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1597382019
- Cited by
- 44
- References
- 46
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 5
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research)
- Funders
- FISABIO (PI12/1984, PI13/1025, PI13/0073, UGP14-093, UGP14-095)
- CIBERehd (CB06/04/0071)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metformin, polycystic ovary syndrome, leukocyte-endothelium interaction, endothelial function, adhesion molecules, inflammatory cytokines, interleukin-6, TNF-α, type 2 diabetes, insulin resistance, VCAM-1, E-selectin, DHEA sulfate, androstenedione, follicle-stimulating hormone
- MeSH terms
- Adolescent, Adult, Cell Adhesion, Cells, Cultured, Diabetes Mellitus, Type 2, Female, Humans, Leukocytes, Metformin, Polycystic Ovary Syndrome, Spain, Time Factors, Biomarkers, Cell Adhesion Molecules, Cytokines, Treatment Outcome, Inflammation Mediators, Coculture Techniques, Leukocyte Rolling, Endothelial Cells, Young Adult, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review