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Neuroendocrine responses to hypoglycemia

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Tesfaye, Nolawit, Seaquist, Elizabeth R.·2010·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2010.05820.xPMC PMC2991551

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Abstract

The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of hypoglycemia. Diabetes, both type 1 and type 2, can perturb these counterregulatory responses. Moreover, defective counterregulation in the setting of diabetes can progress to hypoglycemia unawareness. While the mechanisms that underlie the development of hypoglycemia unawareness are not completely known, possible causes include altered sensing of hypoglycemia by the brain and/or impaired coordination of responses to hypoglycemia. Further study is needed to better understand the intricacies of the counterregulatory response and the mechanisms contributing to the development of hypoglycemia unawareness.

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Authors: Tesfaye, N., & Seaquist, E. R.
Affiliations: University of Minnesota (US)
Corresponding author: Seaquist, Elizabeth R.
ORCID: Seaquist, Elizabeth R.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2010-10-29
Volume: 1212
Issue: 1
Pages: 12-28
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2010.05820.x
PMC: PMC2991551
OpenAlex: W1800997121
Cited by: 164
References: 140
Citations by year: 2026: 7 · 2025: 15 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 24 · 2020: 26 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 4
FWCI: 0.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (2 T32 DK7203-33, T32DK007203)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: hypoglycemia, counterregulatory response, neuroendocrine response, autonomic responses, glucose detection, hypoglycemia unawareness, type 1 diabetes, type 2 diabetes, blood glucose regulation
MeSH terms: Animals, Blood Glucose, Central Nervous System, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemia, Models, Biological, Neurosecretory Systems, Feedback, Physiological

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