The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Neuroendocrine responses to hypoglycemia
Open accessAbstract
The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of hypoglycemia. Diabetes, both type 1 and type 2, can perturb these counterregulatory responses. Moreover, defective counterregulation in the setting of diabetes can progress to hypoglycemia unawareness. While the mechanisms that underlie the development of hypoglycemia unawareness are not completely known, possible causes include altered sensing of hypoglycemia by the brain and/or impaired coordination of responses to hypoglycemia. Further study is needed to better understand the intricacies of the counterregulatory response and the mechanisms contributing to the development of hypoglycemia unawareness.
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“Cortisol has a key role in glucose homeostasis, particularly in the counter-regulatory mechanisms to prevent hypoglycaemia in times of biological stress.”
From Hypoglycaemia in adrenal insufficiency (2023) · cites this paper as [13]
Experimental — accuracy not yet measuredIn the citing paper
“After antecedent hypoglycemia, GH responses were significantly suppressed [ 22 ].”
From Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications (2024) · cites this paper as [22]
In the citing paper
“GH induces glucose level changes over several hours by stimulating lipolysis in adipose tissue as well as ketogenesis and gluconeogenesis in the liver [ 22 , 27 , 28 ].”
From Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications (2024) · cites this paper as [22]
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Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419
Harrison's principles of internal medicine
(2008) · Choice Reviews Online · doi:10.5860/choice.46-0330 · Cited by 3,072
Cryer, P. E., Davis, S. N., & Shamoon, H. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1902 · Cited by 1,160
Defining and Reporting Hypoglycemia in Diabetes
American Diabetes Association Workgroup on Hypoglycemia (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1245 · Cited by 1,146
Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes.
Cryer, P. (2002) · Diabetologia · doi:10.1007/s00125-002-0822-9 · Cited by 794
Gerich, J. E., Langlois, M., Noacco, C., Karam, J. H., & Forsham, P. H. (1973) · Science · doi:10.1126/science.182.4108.171 · Cited by 688
BASIC AND CLINICAL ENDOCRINOLOGY
Poznanski, W. J. (1984) · Elsevier eBooks · doi:10.1016/b978-0-407-00346-0.50001-5 · Cited by 613
Glucose and Osmosensitive Neurones of the Rat Hypothalamus
Oomura, Y., Ono, T., Ooyama, H., & Wayner, M. J. (1969) · Nature · doi:10.1038/222282a0 · Cited by 597
Research works printed but not linked: 5
- 10.1210/jc.78.6.1341 · DOI
- 10.1210/jc.82.5.1458 · DOI
- Peacey S., 1996, Antecedent hypoglycemia does not alter the physiological response to subsequent hypoglycemia in NIDDM [Abstract, Diabetes, 45, 56A
- 10.1210/jc.86.11.5471 · DOI · Paper page
- 10.1210/jc.84.9.3140 · DOI
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Glucosensing and glucose homeostasis: From fish to mammals
Polakof, S., Mommsen, T. P., & Soengas, J. L. (2011) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2011.07.006 · Cited by 316
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Oncologic emergencies: Pathophysiology, presentation, diagnosis, and treatment
Lewis, M. A., Hendrickson, A. W., & Moynihan, T. J. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20124 · Cited by 146
“Signs and symptoms of hypoglycemia arise both from neuroglycopenia and adrenergic counterregulation.(63) Neurologic manifestations range from confusion and blurred vision to seizures and coma.”
BackgroundOtt, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01490.x · Cited by 139
“The fall in blood glucose levels resulting from systemic insulin infusion triggers the graded activation of endocrine axes that can affect brain function [28], and below certain threshold levels inevitably impairs cognition [29].”
BackgroundNeuronal damage and cognitive impairment associated with hypoglycemia: An integrated view
Languren, G., Montiel, T., Julio-Amilpas, A., & Massieu, L. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.06.018 · Cited by 141
“The action of these hormones is slower and takes part in the response to long lasting hypoglycemia such as prolonged fasting or starvation (Beall et al., 2012; Cryer et al., 2003; Cryer, 2006; Tesfaye and Seaquist, 2010).”
Influential
Metadata
- Authors
- Tesfaye, N., & Seaquist, E. R.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Seaquist, Elizabeth R.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-10-29
- Volume
- 1212
- Issue
- 1
- Pages
- 12-28
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC2991551
- OpenAlex
- W1800997121
- Cited by
- 164
- References
- 140
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 24 · 2020: 26 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (2 T32 DK7203-33, T32DK007203)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- hypoglycemia, counterregulatory response, neuroendocrine response, autonomic responses, glucose detection, hypoglycemia unawareness, type 1 diabetes, type 2 diabetes, blood glucose regulation
- MeSH terms
- Animals, Blood Glucose, Central Nervous System, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemia, Models, Biological, Neurosecretory Systems, Feedback, Physiological
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