Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

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Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring

Ramos‐Rodríguez, J. J., Sanchez-Sotano, D., Doblas-Márquez, A., Infante‐Garcia, C., Lubián‐López, S. P., & Garcı́a-Alloza, M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0198-4 · Cited by 28 · see citing works

Hippocampal insulin resistance and altered food decision-making as players on obesity risk

Mucellini, A. B., da Fonseca, N. K. D. O., Manfro, G. G., & Silveira, P. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.011 · Cited by 26 · see citing works

Sugar in mind: Untangling a sweet and sour relationship beyond type 2 diabetes

Cherbuin, N., & Walsh, E. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100769 · Cited by 24 · see citing works

CHCHD2 p. Thr61Ile knock‐in mice exhibit motor defects and neuropathological features of Parkinson's disease

Fan, L., Zhang, S., Li, X., Hu, Z., Yang, J., Zhang, S., Zheng, H., Su, Y., Luo, H., Liu, X., et al. (2022) · Brain Pathology · doi:10.1111/bpa.13124 · Cited by 24 · see citing works

Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis

Sun, M., Li, Y., Liu, M., Li, Q., Shi, L., Ruan, X., Huo, Y., Zhou, Z., Zhang, X., Ma, Y., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175929 · Cited by 23 · see citing works

Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents

Sarnyai, Z., Jashar, C., & Olivier, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.016 · Cited by 22 · see citing works

Diabesity and Brain Energy Metabolism: The Case of Alzheimer’s Disease

Cardoso, S., Seiça, R. M. F., & Moreira, P. I. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_5 · Cited by 22 · see citing works

Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

Jiang, L., Wang, Y., Su, L.-Y., Ren, H., Wang, C., Chen, J., & Fu, X. (2019) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000504800 · Cited by 21 · see citing works

Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome

Derkach, K. V., Ivantsov, A. O., Chistyakova, O. V., Sukhov, I. B., Buzanakov, D. M., Kulikova, A. A., & Shpakov, A. O. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3762-6 · Cited by 21 · see citing works

Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice

Alvarez-Ricartes, N., Oliveros-Matus, P., Mendoza, C., Perez-Urrutia, N., Echeverria, F., Iarkov, A., Barreto, G. E., & Echeverrı́a, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0916-0 · Cited by 21 · see citing works

The olfactory system in Alzheimer’s disease: Pathology, pathophysiology and pathway for therapy

Kovács, T. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0108-3 · Cited by 20 · see citing works

Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study

Sun, M., Liu, M., Zhang, F., Sang, L., Song, Y., Li, P., Liu, S., Yang, H., Ma, L., Cao, J., et al. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02084-2 · Cited by 19 · see citing works

An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus

Eckstrand, K., Mummareddy, N., Kang, H., Cowan, R. L., Zhou, M., Zald, D. H., Silver, H. J., Niswender, K. D., & Avison, M. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189113 · Cited by 18 · see citing works

Insulin sensitivity predicts brain network connectivity following a meal

Ryan, J. P., Karim, H. T., Aizenstein, H. J., Helbling, N. L., & Toledo, F. G. S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.024 · Cited by 18 · see citing works

Insulin resistance is associated with verbal memory impairment in bipolar disorders

Salvi, V., Salvo, G. D., Korčáková, J., Torriero, S., Aragno, E., Kolenič, M., Ungrmanová, M., Maina, G., Mencacci, C., & Hájek, T. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.145 · Cited by 17 · see citing works

In Vivo Changes in Central and Peripheral Insulin Sensitivity in a Large Animal Model of Obesity

Adam, C. L., Findlay, P. A., Aitken, R. P., Milne, J. S., & Wallace, J. M. (2012) · Endocrinology · doi:10.1210/en.2012-1134 · Cited by 17 · see citing works

Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial

Yang, M., Zhou, L., Long, G., Liu, X., Ouyang, W., Xie, C., & He, X. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s491300 · Cited by 17 · see citing works

Position on zinc delivery to olfactory nerves in intranasal insulin phase I–III clinical trials

Hamidovic, A. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.08.011 · Cited by 16 · see citing works

The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes

Mizuno, M., Hotta, N., Ishizawa, R., Kim, H., Iwamoto, G. A., Vongpatanasin, W., Mitchell, J. H., & Smith, S. A. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000259 · Cited by 15 · see citing works

Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice

Tytell, M., Davis, A., Giles, J. M., Snider, L. C., Xiao, R., Dozier, S., Presley, T. D., & Kavanagh, K. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0835-4 · Cited by 14 · see citing works

Neuronal Insulin Receptor Signaling: A Potential Target for the Treatment of Cognitive and Mood Disorders

Yanagita, T., Nemoto, T., Satoh, S., Yoshikawa, N., Maruta, T., Shiraishi, S., Sugita, C., & Murakami, M. (2013) · InTech eBooks · doi:10.5772/54389 · Cited by 13 · see citing works

Metabolic pathways in the periphery and brain: Contribution to mental disorders?

Nagalski, A., Koziński, K., & Wisniewska, M. B. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.012 · Cited by 14 · see citing works

Protective effect of intranasal insulin on postoperative cognitive dysfunction in elderly patients with metabolic syndrome undergoing noncardiac surgery: a randomized clinical trial

Mi, Y., Ouyang, W., Long, G., Liu, X., Jianbin, T., Yongzhong, T., & Xi, H. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02593-7 · Cited by 12 · see citing works

Brain Insulin and Leptin Signaling in Metabolic Control

Scherer, T., Lehnert, H., & Hallschmid, M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.002 · Cited by 11 · see citing works

Neuropathogenesis of HIV and emerging therapeutic targets

Siddiqui, A., He, C., Lee, G., Figueroa, A., Slaughter, A. W., & Robinson‐Papp, J. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2100253 · Cited by 12 · see citing works

Expression of human apolipoprotein E4 reduces insulin‐receptor substrate 1 expression and Akt phosphorylation in the ageing liver

Ong, Q.-R., Chan, E. S., Lim, M., & Wong, B. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.02.011 · Cited by 12 · see citing works

Coadministration of Intranasally Delivered Insulin and Proinsulin C-Peptide to Rats with Types 1 and 2 Diabetes Mellitus Restores Their Metabolic Parameters

Derkach, K. V., Бондарева, В. М., & Shpakov, A. O. (2018) · Advances in Gerontology · doi:10.1134/s2079057018020030 · Cited by 10 · see citing works

Evaluation of a single dose of intra‐testicular insulin treatment in heat‐stressed mice model

Jeremy, M., Gurusubramanian, G., Kharwar, R. K., & Roy, V. K. (2022) · Andrologia · doi:10.1111/and.14603 · Cited by 10 · see citing works

Glycemic control level alters working memory neural dynamics in adults with type 2 diabetes

Embury, C. M., Lord, G. H., Drincic, A., Desouza, C. V., & Wilson, T. W. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad119 · Cited by 9 · see citing works

Hippocampal‐Specific Insulin Resistance Elicits Synaptic Effects on Glutamate Neurotransmission

Erichsen, J. M., Woodruff, J. L., Grillo, C. A., Piroli, G. G., Fadel, J. R., & Reagan, L. P. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70083 · Cited by 8 · see citing works

Association between triglyceride-glucose index and postoperative delirium following cardiac surgery: a multicenter retrospective analysis

Zeng, J., Li, N., Ma, C., Song, Y., Tian, W., Gao, Y., Tang, S., Liu, X., & Tian, X. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02769-2 · Cited by 8 · see citing works

Hindbrain insulin controls feeding behavior

Eerola, K., Longo, F., Reinbothe, T. M., Richard, J. E., Shevchouk, O. T., López‐Ferreras, L., Mishra, D., Asker, M., Tolö, J., MIRANDA, C. A., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101614 · Cited by 8 · see citing works

TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response

Zhu, Q., Zhu, Y., & Wang, W. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.058 · Cited by 8 · see citing works

Von der Nase ins Gehirn

Brünner, Y. F., Benedict, C., & Freiherr, J. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3806-8 · Cited by 6 · see citing works

Differential impact of glycemic control and comorbid conditions on the neurophysiology underlying task switching in older adults with type 2 diabetes

Embury, C. M., Lord, G. H., Drincic, A., Desouza, C. V., & Wilson, T. W. (2022) · Aging · doi:10.18632/aging.204129 · Cited by 5 · see citing works

Investigating the effects of antipsychotics on brain insulin action: Study protocol for a multi-modality magnetic resonance imaging (MRI) study in healthy controls

Stogios, N., Hamel, L., Smith, E., Sanches, M., Remington, G. J., Voineskos, A. N., Dash, S., Graff‐Guerrero, A., Hahn, M., & Agarwal, S. M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277211 · Cited by 5 · see citing works

Microbiome-driven alterations in metabolic pathways and impaired cognition in aged female TgF344-AD rats

Hernandez, A. R., Parker, E. S., Babar, M., Banerjee, A., Ding, S., Simley, A. L., & Buford, T. W. (2024) · Aging Brain · doi:10.1016/j.nbas.2024.100119 · Cited by 5 · see citing works

Effect of intranasal insulin on peripheral glucose profile in dexamethasone-induced insulin resistance in Wistar rats

Njan, A. A., Fatigun, C. O., Alli-Oluwafuyi, A., Olorundare, O. E., Afolabi, O. S., Akinola, O., & Amin, A. (2018) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1016/j.bjbas.2018.06.003 · Cited by 5 · see citing works

Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes

Dhindsa, S., Chemitiganti, R., Ghanim, H., Santiago, E., Haider, A., Natalia, C., Mok, M., McKee, A. M., & Dandona, P. (2018) · International Journal of Endocrinology · doi:10.1155/2018/6170154 · Cited by 5 · see citing works

Outcomes and clinical implications of intranasal insulin administration to the central nervous system

Santiago, J. C. P., & Hallschmid, M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.007 · Cited by 36 · see citing works

Intranasal insulin

Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113 · see citing works

Prospects of intranasal insulin for correction of cognitive impairments, in particular those associated with diabetes mellitus

Surkova, E. V., Derkach, K. V., Bespalov, A. I., & Shpakov, A. O. (2019) · Problems of Endocrinology · doi:10.14341/probl9755 · Cited by 5 · see citing works

Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans

Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.022 · Cited by 191 · see citing works

Targeting metabolic and cognitive pathways of the CNS by intranasal insulin administration

Hallschmid, M., Benedict, C., Jan Born, A., & Kern, W. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.4.319 · Cited by 22 · see citing works