Stem cells in endometrium and their role in the pathogenesis of endometriosis
Open accessAbstract
The human endometrium is a dynamic tissue that undergoes cycles of growth and regression with each menstrual cycle. Adult progenitor stem cells are likely responsible for this remarkable regenerative capacity; these same progenitor stem cells may also have an enhanced capacity to generate endometriosis if shed in a retrograde fashion. The progenitor stem cells reside in the uterus; however, less‐committed mesenchymal stem cells may also travel from other tissues such as bone marrow to repopulate the progenitor population. Mesenchymal stem cells are also involved in the pathogenesis of endometriosis and may be the principle source of endometriosis outside of the peritoneal cavity when they differentiate into endometriosis in ectopic locations. Finally, besides progenitor stem cells, recent publications have identified multipotent stem cells in the endometrium. These multipotent stem cells are a readily available source of cells that are useful in tissue engineering and regenerative medicine. Endometrial stem cells have been used to generate chondrocytes, myocytes, neurons, and adiposites in vitro as well as to replace dopaminergic neurons in a murine model of Parkinson's disease.
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Mesenchymal stem cells may travel from other tissues such as bone marrow to repopulate the progenitor population.
“Although progenitor stem cells reside in the uterus, mesenchymal stem cells may also travel from other tissues such as bone marrow to repopulate the progenitor population.105,106”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [105]
The coelomic metaplasia theory may explain the presence of endometriosis in pre-pubertal girls and the formation of ovarian endometriomas.
“This theory may explain the presence of endometriosis in pre-pubertal girls [ 37 ] and the formation of ovarian endometriomas [ 38 ].”
From Thoracic Endometriosis Syndrome: A Comprehensive Review and Multidisciplinary Approach to Management (2024) · cites this paper as [37]
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References 53 · Cited by 188
- Authors
- Figueira, P. G. M., Abrão, M. S., Krikun, G., & Taylor, H.
- Affiliations
- Universidade de São Paulo (BR)
- Yale University (US)
- Corresponding author
- Krikun, Graciela
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-03
- Volume
- 1221
- Issue
- 1
- Pages
- 10-17
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC3076708
- OpenAlex
- W1502197914
- Cited by
- 188
- References
- 53
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 9 · 2023: 12 · 2022: 21 · 2021: 9 · 2020: 19 · 2019: 7 · 2018: 16 · 2017: 18 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 9 · 2012: 4
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- endometrial stem cells, endometriosis pathogenesis, mesenchymal stem cells, retrograde menstruation, ectopic endometriosis, multipotent stem cells, tissue engineering, regenerative medicine, Parkinson's disease, endometrial regeneration
- MeSH terms
- Endometriosis, Endometrium, Female, Humans, Pregnancy, Stem Cells
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