The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction
Open accessAbstract
Enhanced susceptibility to inflammatory and autoimmune disease can be related to impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid resistance resulting from impairments in local factors affecting glucocorticoid availability and function, including the glucocorticoid receptor (GR). The enhanced inflammation and hypercortisolism that typically characterize stress‐related illnesses, such as depression, metabolic syndrome, cardiovascular disease, or osteoporosis, may also be related to increased glucocorticoid resistance. This review focuses on impaired GR function as a molecular mechanism of glucocorticoid resistance. Both genetic and environmental factors can contribute to impaired GR function. The evidence that glucocorticoid resistance can be environmentally induced has important implications for management of stress‐related inflammatory illnesses and underscores the importance of prevention and management of chronic stress. The simultaneous assessment of neural, endocrine, and immune biomarkers through various noninvasive methods will also be discussed.
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Cites
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
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Metadata
- Authors
- Silverman, M. N., & Sternberg, E. M.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2012-07
- Volume
- 1261
- Issue
- 1
- Pages
- 55-63
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1732425222
- Cited by
- 731
- References
- 100
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Silverman, M. N., & Sternberg, E. M. (2012). Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2012.06633.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
