Cited by 571Glioma Diagnosis and TreatmentCancer-related Molecular PathwaysChromatin Remodeling and Cancer

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Frequent Co‐Alterations of TP53, p16/CDKN2A, p14 ARF , PTEN Tumor Suppressor Genes in Human Glioma Cell Lines.

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Ishii, Nobuaki, Maier, Daniel, Merlo, Adrian, Tada, Mitsuhiro, Sawamura, Yutaka, Diserens, Annie‐Claire, Van Meir, Erwin G.·1999·Brain Pathology

DOI 10.1111/j.1750-3639.1999.tb00536.xPMC PMC8098486

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Abstract

In this study we established the simultaneous status of TP53, p16, p14ARF and PTEN tumor suppressor genes in 34 randomly chosen human glioma cell lines. Nine cell lines (26.4%) harbored mutations or deletions in all four tumor suppressor genes and 22 cell lines (64%) had alterations in at least three. Mutations/deletions were found at the following frequencies: TP53 (76.5%), p14ARF (64.7%), p16 (64.7%), PTEN (73.5%). Thus, there was a high incidence of alterations in the cellular pathways involving the p53 transcription factor (94.1%), the retinoblastoma protein (64.7%) and the PTEN phosphatase (73.5%) and 91% of cell lines carried mutations in two or more pathways. This provides the first clear genetic evidence that these tumor suppressors participate in biological pathways which are functioning separately/independently in glioma cells. The status of the gene alterations did not correlate with tumorigenicity in immunocompromized mice or any clinical parameters. Although the mutation rate was higher in glioma cell lines than that reported for glioma tissues, the alterations were molecularly representative of those found in adult de novo glioblastoma. This study highlights the importance of developing therapeutic approaches applicable to tumors with a broad range of genetic alterations and also provides an invaluable panel of glioma cell lines to make this possible.

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PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0497-356 · Cited by 2,742
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,992
Self-citation
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53
Pomerantz, J., Schreiber-Agus, N., Liégeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81400-2 · Cited by 1,521
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
Kamb, A., Shattuck-Eidens, D. M., Eeles, R. A., Liu, Q., Gruis, N. A., Ding, W., Hussey, C. E., Tran, T., Miki, Y., Weaver-Feldhaus, J., et al. (1994) · Nature Genetics · doi:10.1038/ng0994-22 · Cited by 855
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. E., & Tonks, N. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9052 · Cited by 775

Show all 48 references

Research works printed but not linked: 1

KleihuesP CaveneeWK(1997).Pathology and Genetics of Tumors of the Nervous System.International Agency for Research on Cancer: 1st edition Lyon.

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Cong, Y., Jia, W. W.-G., Chen, J., Song, S., Wang, J., & Yang, Y. (2007) · Helvetica Chimica Acta · doi:10.1002/hlca.200790087 · Cited by 22
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Rahman, A. A., Jamal, A. R. A., Harun, R., Mokhtar, N. M., & Ngah, W. Z. W. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-213 · Cited by 21
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Magro, A. M., Magro, A., Cunningham, C., & Miller, M. R. (2007) · PubMed · Cited by 21
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Koivisto, P. A., Zhang, X., Sallinen, S., Sallinen, P. K., Helin, H. J., Dong, J., Meir, E. G. V., Haapasalo, H. K., & Hyytinen, E. (2004) · International Journal of Cancer · doi:10.1002/ijc.20301 · Cited by 21
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Sinha, S., Renganathan, A., Nagendra, P. B., Bhat, V., Mathew, B. S., & Rao, M. R. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-51068-1 · Cited by 20
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Authors: Ishii, N., Maier, D., Merlo, A., Tada, M., Sawamura, Y., Diserens, A., & Van Meir, E. G.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
University Hospital of Basel (CH)
Hokkaido University (JP)
ORCID: Ishii, Nobuaki
Tada, Mitsuhiro
Venue: Brain Pathology
Publisher: Wiley
Published: 1999-07
Volume: 9
Issue: 3
Pages: 469-479
ISSN: 1015-6305 (ISSN-L)
1750-3639
DOI: 10.1111/j.1750-3639.1999.tb00536.x
PMC: PMC8098486
OpenAlex: W2155140015
Cited by: 569
References: 48
Citations by year: 2026: 9 · 2025: 10 · 2024: 24 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 13 · 2019: 25 · 2018: 14 · 2017: 16 · 2016: 14 · 2015: 27 · 2014: 33 · 2013: 25 · 2012: 34
FWCI: 11.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2470 d)
Locations: Brain Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: glioma cell lines, TP53 mutation, CDKN2A/p16, p14ARF, PTEN, p53 pathway, glioblastoma, tumorigenicity, genetic alterations
MeSH terms: Adult, Aged, Animals, Brain Neoplasms, Child, DNA Mutational Analysis, Female, Glioma, Humans, Male, Mice, Nude, Middle Aged, Neoplasm Transplantation, Neoplastic Processes, Phosphoric Monoester Hydrolases, Proteins, Sex Factors, Tumor Cells, Cultured, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, Point Mutation, Sequence Deletion, Cyclin-Dependent Kinase Inhibitor p16, Tumor Suppressor Proteins, Tumor Suppressor Protein p14ARF, PTEN Phosphohydrolase, Mice

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Frequent Co‐Alterations of TP53, p16/CDKN2A, p14 ARF , PTEN Tumor Suppressor Genes in Human Glioma Cell Lines.

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