Frequent Co‐Alterations of TP53, p16/CDKN2A, p14 ARF , PTEN Tumor Suppressor Genes in Human Glioma Cell Lines.

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase

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P14ARF Suppresses Tumor-Induced Thrombosis by Regulating the Tissue Factor Pathway

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Rarity of JC virus DNA sequences and early proteins in human gliomas and medulloblastomas: the controversial role of JC virus in human neurooncogenesis

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p14ARF Expression Increases Dihydrofolate Reductase Degradation and Paradoxically Results in Resistance to Folate Antagonists in Cells with Nonfunctional p53

Magro, P. G., Russo, A. J., Li, W., Banerjee, D., & Bertino, J. R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1045 · Cited by 16

Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti‐apoptotic potential under reoxygenation

Kinoshita, M., Johnson, D. L., Shatney, C. H., Lee, Y. L., & Mochizuki, H. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(200002)9999:9999 · Cited by 51

Loss of Sparc in p 53‐null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival

Thomas, S. L., Schultz, C. R., Mouzon, E., Golembieski, W., Naili, R. E., Radakrishnan, A., Lemke, N. W., Poisson, L., Gutierrez, J. A., Cottingham, S. L., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12161 · Cited by 15

Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic, and antitumor efficacy

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Down-regulation of Wilms’ tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53

Clark, A. J., Chan, D. C., Chen, M. Y., Fillmore, H. L., dos Santos, W. G., Meter, T. E. V., Graf, M. R., & Broaddus, W. C. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9317-8 · Cited by 15

Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines

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Gene expression profile in a glioma cell line resistant to cell death induced by a the chimeric tumor suppressor-1 (CTS-1), a dominant-positive variant of p53—the role of NFκB

Seznec, J., Weit, S., & Naumann, U. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp319 · Cited by 15

Tumours

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C18H17NO6and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression

He, X., Xiong, L.-L., Xia, Q., Wang, Y., Zhao, X., Du, R., Huang, J., He, X., Liu, J., & Wang, T. (2019) · BioMed Research International · doi:10.1155/2019/6821219 · Cited by 15

Down-regulation of the inhibitor of growth 1 (ING1) tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death

Tallen, U. G., Truß, M., Kunitz, F., Wellmann, S. M., Unryn, B. M., Sinn, B., Laß, U., Krabbe, S., Holtkamp, N., Hagemeier, C., et al. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9436-x · Cited by 15

Engineering PTEN-L for Cell-Mediated Delivery

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A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells

Paulmurugan, R., Afjei, R., Sekar, T. V., Babikir, H. A., & Massoud, T. F. (2018) · Oncotarget · doi:10.18632/oncotarget.25138 · Cited by 14

Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner.

Hohmann, T., Feese, K., Greither, T., Ghadban, C., Jäger, V., Dehghani, F., & Hohmann, U. (2019) · Cancers · doi:10.3390/cancers11020161 · Cited by 14

PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors

Benedetti, E., Galzio, R. J., D’Angelo, B., Cerù, M. P., & Cimini, A. (2010) · PPAR Research · doi:10.1155/2010/427401 · Cited by 14

Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of GliomaIn VitroandIn Vivoin Glioblastoma Bearing Mice

Schötterl, S., Miemietz, J. T., Ilina, E. I., Wirsik, N. M., Ehrlich, I., Gall, A., Huber, S. M., Lentzen, H., Mittelbronn, M. G. A., & Naumann, U. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1376140 · Cited by 14

Glycation Interferes with the Expression of Sialyltransferases and Leads to Increased Polysialylation in Glioblastoma Cells

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Environmental interplay: Stromal cells and biomaterial composition influence in the glioblastoma microenvironment

Hatlen, R. R., & Rajagopalan, P. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.044 · Cited by 13

Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis

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Overexpression of prothymosin-α in glioma is associated with tumor aggressiveness and poor prognosis

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ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors

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Inhibition of metabotropic glutamate receptor 5 facilitates hypoxia-induced glioma cell death

Liu, B., Zhao, S., Qi, C., Zhao, X., Liu, B., Fang, H., & Zhao, Z. (2018) · Brain Research · doi:10.1016/j.brainres.2018.10.021 · Cited by 12

Transcriptome analysis reveals the molecular mechanisms of combined gamma-tocotrienol and hydroxychavicol in preventing the proliferation of 1321N1, SW1783, and LN18 glioma cancer cells

Rahman, A. A., Mokhtar, N. M., Harun, R., Jamal, R., & Ngah, W. Z. W. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00699-z · Cited by 12

Cell-Based Glioma Models for Anticancer Drug Screening: From Conventional Adherent Cell Cultures to Tumor-Specific Three-Dimensional Constructs

Lanskikh, D., Kuziakova, O., Baklanov, I., Penkova, A. O., Doroshenko, V., Buriak, I., Zhmenia, V., & Kumeiko, V. V. (2024) · Cells · doi:10.3390/cells13242085 · Cited by 12

Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells

Toledano, S., Sabag, A. D., Ilan, N., Liburkin-Dan, T., Kessler, O., & Neufeld, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05554-0 · Cited by 11

Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line

Wang, M., Maier, P. J., Wenz, F. K., Giordano, F. A., & Herskind, C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1232-1 · Cited by 11

Therapeutic Hypothesis Testing With Rodent Brain Tumor Models

Wainwright, D. A., Horbinski, C., Hashizume, R., & James, C. D. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0523-1 · Cited by 11

Comparative analyses of individual and multiple alterations of p53, PTEN and p16 in non-small cell lung carcinoma, glioma and breast carcinoma samples

Stanković, T., Milinković, V., Banković, J., Dinić, J., Tanić, N., Dramićanin, T., & Tanić, N. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.03.014 · Cited by 11

Bioinformatical analysis of gene expression signatures of different glioma subtypes

Wang, R., Wei, J., Li, Z., Tian, Y., & Du, C. (2017) · Oncology Letters · doi:10.3892/ol.2017.7660 · Cited by 10

Differential Exosomic Proteomic Patterns and Their Influence in Resveratrol Sensitivities of Glioblastoma Cells

Nie, J., Li, H., Wu, M., Lin, X.-M., Xiong, L., & Liu, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010191 · Cited by 10

Smurf1 silencing restores PTEN expression that ameliorates progression of human glioblastoma and sensitizes tumor cells to mTORC1/C2 inhibitor Torin1

Qin, X., Li, W., Ali, S., Xu, M., Li, Y., Li, S., Meng, X., Liu, L., & Dong, L. (2021) · iScience · doi:10.1016/j.isci.2021.103528 · Cited by 11

Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types

Gorjala, P., & Gary, R. K. (2010) · BioMetals · doi:10.1007/s10534-010-9352-y · Cited by 10

Pharmacologic manipulations of mitochondrial membrane potential (ΔΨm) selectively in glioma cells

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INK4a/Arf is required for suppression of EGFR/ΔEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma

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The language of glioblastoma: A tale of cytokines and sex hormones communication

Alemán, O. R., Quintero, J. C., & Camacho‐Arroyo, I. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf017 · Cited by 9

Intranasal Delivery of Oncolytic Adenovirus XVir-N-31 via Optimized Shuttle Cells Significantly Extends Survival of Glioblastoma-Bearing Mice

El-Ayoubi, A., Klawitter, M., Rüttinger, J., Wellhäusser, G., Holm, P. S., Danielyan, L., & Naumann, U. (2023) · Cancers · doi:10.3390/cancers15204912 · Cited by 9

A Chimeric Signal Peptide–Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell–Specific Apoptosis

Lee, S.-H., Rehman, F. K., Tyler, K. C., Yu, B., Zhang, Z., Osuka, S., Zerrouqi, A., Kaluzová, M., Hadjipanayis, C. G., Cummings, R. D., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3280 · Cited by 9

Formononetin inhibits osteosarcoma cell proliferation and promotes apoptosis by regulating the miR-214-3p/phosphatase and tensin homolog pathway

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Thallium Induces Antiproliferative and Cytotoxic Activity in Glioblastoma C6 and U373 Cell Cultures via Apoptosis and Changes in Cell Cycle

Rangel‐López, E., Robles-Bañuelos, B., Guadiana-Ramírez, N., Álvarez-Garduño, V., Galván‐Arzate, S., Zazueta, C., Karasu, Ç., Túnez, I., Tinkov, A. A., Aschner, M., et al. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00514-6 · Cited by 9

Temozolomide and Lomustine Induce Tissue Factor Expression and Procoagulant Activity in Glioblastoma Cells In Vitro

Kapteijn, M. Y., Zwaan, S., ter Linden, E., Laghmani, E. H., van den Akker, R. F. P., Rondon, A. M. R., van der Zanden, S. Y., Neefjes, J., Versteeg, H. H., & Buijs, J. T. (2023) · Cancers · doi:10.3390/cancers15082347 · Cited by 9

Repression of p53-mediated Transcription by Adenovirus E1B 55-kDa Does Not Require Corepressor mSin3A and Histone Deacetylases

Zhao, L., Santiago, A., Liu, J., & Liao, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610749200 · Cited by 9

Bay846, a new irreversible small molecule inhibitor of EGFR and Her2, is highly effective against malignant brain tumor models

Longo, S. L., Padalino, D. J., McGillis, S. L. B., Petersen, K., Schirok, H., Politz, O., Canute, G. W., & Post, D. E. (2011) · Investigational New Drugs · doi:10.1007/s10637-011-9784-4 · Cited by 9

Necrosis is not induced by gadolinium neutron capture in glioblastoma multiforme cells

Yasui, L. S., & Owens, K. (2012) · International Journal of Radiation Biology · doi:10.3109/09553002.2012.715787 · Cited by 9

The cell cycle inhibitor p21CIP1 is essential for irinotecan-induced senescence and plays a decisive role in re-sensitization of temozolomide-resistant glioblastoma cells to irinotecan

Sallbach, J., Woods, M., Rasenberger, B., Christmann, M., & Tomicic, M. T. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117634 · Cited by 10

A small interference RNA screen revealed proteasome inhibition as strategy for glioblastoma therapy.

Ng, K., Nitta, M., Hu, L., Kesari, S., Kung, A. L., D’Andrea, A. D., & Chen, C. C. (2009) · PubMed · Cited by 8

Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG

Nguyen, T. T., Rajakannu, P., Pham, M. D. T., Weman, L., Jucht, A., Buri, M. C., Dommelen, K. V., & Hegi, M. E. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13494 · Cited by 9

The EP3–ZNF488 Axis Promotes Self-Renewal of Glioma Stem-Like Cells to Induce Resistance to Tumor Treating Fields

Chen, D., Le, S. B., Manektalia, H., Liu, T., Hutchinson, T. E., O’Dell, A., Salhia, B., & Tran, D. D. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3643 · Cited by 12

Synthesis, characterization, and anticancer properties of iminophosphineplatinum(II) complexes containing boronate esters

St‐Cœur, P., Kinley, S., Vogels, C. M., Decken, A., Morin, P., & Westcott, S. A. (2016) · Canadian Journal of Chemistry · doi:10.1139/cjc-2016-0570 · Cited by 8

ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition

Cao, C., He, K., Li, S., Ge, Q., Liu, L., Zhang, Z., Zhang, H., Wang, X., Sun, X., & Ding, L. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110062 · Cited by 8

The Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach

El‐Baba, C., Ayache, Z., Goli, M., Hayar, B., Kawtharani, Z., Pisano, C., Kobeissy, F. H., Mechref, Y. S., & Darwiche, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814069 · Cited by 8

Progesterone Receptor Subcellular Localization and Gene Expression Profile in Human Astrocytoma Cells Are Modified by Progesterone

González‐Arenas, A., Cabrera‐Wrooman, A., Díaz, N. F., González-García, T. K., Salido-Guadarrama, I., Rodríguez‐Dorantes, M., & Camacho‐Arroyo, I. (2014) · Nuclear Receptor Research · doi:10.11131/2014/101098 · Cited by 8

Proteomics-based analysis of a pair of glioma cell lines with different tumor forming characteristics

Zhou, L., Wang, Y., Zhang, Y., Geng, Y., Si, L., & Wang, Y.-L. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.080 · Cited by 8

Regulation of c-Myc and NBS1 by ionizing radiation in glioblastoma cells

Rodrigues, P. M. G., de Souza, R. S., Borges, H. L., & Martins, R. A. P. (2017) · Oncology Signaling · doi:10.1016/j.onsig.2017.12.001 · Cited by 7

Investigating Trans-differentiation of Glioblastoma Cells in an In Vitro 3D Model of the Perivascular Niche

Hatlen, R. R., & Rajagopalan, P. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01310 · Cited by 7

The NF-κB Signaling Pathway in GBMs: Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy

Laver, T., Nozell, S. E., & Benveniste, E. N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-553-8_42 · Cited by 7

A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

Das, D., Duncton, M. A. J., Georgiadis, T. M., Pellicena, P., Clark, J., Sobol, R. W., Georgiadis, M. M., King-Underwood, J., Jobes, D. V., Chang, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316637 · Cited by 7

Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells

Han, X., Li, H., Zhang, Y., Qin, J., Yang, Q., Wang, L., Yuan, M., & Xia, C. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4132 · Cited by 6

MicroRNA-19a promotes glioma cell growth by repressing LRIG1.

Shao, L., Yang, J., Wang, Y.-F., Wu, P., Li, J., & Chen, Q. (2014) · PubMed Central · Cited by 7

Biological intratumoral therapy for the high-grade glioma part II: vector- and cell-based therapies and radioimmunotherapy

Loya, J. J., Zhang, C., Cox, E. J., Achrol, A. S., & Kesari, S. (2019) · CNS Oncology · doi:10.2217/cns-2019-0002 · Cited by 7

MOLECULAR BIOLOGY OF NERVOUS SYSTEM TUMORS

Rempel, S. A. (2001) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70263-x · Cited by 7

Overexpression of RFT induces G1–S arrest and apoptosis via p53/p21Waf1 pathway in glioma cell

Kano, H., Arakawa, Y., Takahashi, J. A., Nozaki, K., Kawabata, Y., Takatsuka, K., Kageyama, R., Ueba, T., & Hashimoto, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.120 · Cited by 7

Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma

Abdullah, J. M., Zainuddin, N., Sulong, S., Jaafar, H., & Isa, M. N. (2003) · Neurosurgical FOCUS · doi:10.3171/foc.2003.14.4.6 · Cited by 7

Effect of radiation on cytokine and cytokine receptor messenger-RNA profiles in p53 wild and mutated human glioblastoma cell lines.

Yee, D., Hao, C., Cheung, H., Chen, H. T., Dabbagh, L., Hanson, J., Coupland, R. W., Petruk, K. C., Fulton, D. S., & Roa, W. (2001) · PubMed · Cited by 7

Combinatorial treatment of glioblastoma with temozolomide (TMZ) plus 5-ethynyl-2′-deoxyuridine (EdU)

Kaanoglu, H., Akyel, Y. K., Adefolaju, A., Valdivia, A., Higgins, D. M. O., Sellers, R. S., Mosely, C., Haswell, C. J., Zamboni, W. C., Hingtgen, S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2532187123 · Cited by 7

Establishment and characteristics of GWH04, a new primary human glioblastoma cell line

Guo, D., Cheng, F., 毛峰, 万雪燕, Li, Y., Peng, P., Xu, S., Han, C., & Wang, B. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5429 · Cited by 6

Repurposing the DNA Labeling Agent EdU for Therapy against Heterogeneous Patient Glioblastoma

Kaanoglu, H., Adefolaju, A., Fraley, C., Shobande, M., Dasari, R., Mann, B., Bell, N., Keir, S. T., Higgins, D. M. O., Kram, D. E., et al. (2025) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-24-1098 · Cited by 6

Innate Immune Receptor NLRX1: Potential Modulator of Glioblastoma Pathophysiology

Meena, D., Shivakumar, D., Rajkhowa, S., Solanki, P., Chhipa, S., Bhattacharya, N., Revanth, M. S., Kumar, D., Janu, V., Garg, M., et al. (2026) · Journal of Cellular Physiology · doi:10.1002/jcp.70163 · Cited by 6

Hierarchical closeness-based properties reveal cancer survivability and biomarker genes in molecular signaling networks

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Peptide Dendrimers with Non-Symmetric Bola Structure Exert Long Term Effect on Glioblastoma and Neuroblastoma Cell Lines

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