CoChat
Sign Up
Cited by 38Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Decreased Oligodendrocyte Nuclear Diameter in Alzheimer's Disease and Lewy Body Dementia

Open access
Gagyi, Eva, Kormos, Bernadett, Castellanos, Karla J., Valyi‐Nagy, Klara, Korneff, Dennis, LoPresti, Patrizia, Woltjer, Randy, Valyi‐Nagy, Tibor·2012·Brain Pathology
DOI 10.1111/j.1750-3639.2012.00595.xPMC PMC4181948
Open this paper in CoChat — free account

Abstract

To better understand the pathogenesis of dementia, it is important to understand histopathologic changes in neurodegenerative diseases because they might highlight key aspects of the degenerative process. In this study, the nuclear diameter of neurons and oligodendrocytes in selected temporal lobe areas were determined in autopsy tissue sections from patients with Alzheimer's disease (AD), Lewy body dementia (LBD) and controls. Our morphometric studies targeted neurons in the CA4 region of the pyramidal cell layer of the hippocampus, neurons in the granular layer of the dentate gyrus and oligodendrocytes in parahippocampal white matter. Mean neuronal nuclear diameters were not different among the studied groups. However, our studies revealed a statistically significant reduction of mean oligodendrocyte nuclear diameter in AD and LBD relative to controls. The reduction of the mean nucleus diameter of oligodendrocytes in LBD was independent of the presence of associated AD pathology in LBD. These findings for the first time identify decreased oligodendrocyte nucleus diameter as a morphologic feature of AD and LBD and may lead to a better understanding of the role of oligodendrocytes in AD and LBD pathogenesis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1750-3639.2012.00595.x

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • AD pathology in the white matter includes loss of myelin and a decrease in oligodendrocyte proteins.

    “AD pathology in the white matter includes the loss of myelin and a decrease in oligodendrocyte proteins [62–68].”

    From Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts (2016) · cites this paper as [65]

    The Discussion (page not available in our copy) describes myelin loss in AD white matter, citing a prior study, and the paper reports smaller oligodendrocyte nuclei in AD. It does not report a decrease in oligodendrocyte proteins; nuclear diameter is not a protein measurement. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 32

  1. [1]Ball M Braak H Coleman P Dickson D Duyckaerts C Gambietti P Hansen L Hyman B Jellinger B Markersbery W Perl D Powers J Wisniewski H Phelps C Khachaturian Z Trojanowski JQ 1997 Consensus recommendations for the postmortem diagnosis of Alzheimer’s disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease Neurobiol Aging 18 4Suppl S1 2 9330978
  2. [2]Bartzokis G 2004 Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease Neurobiol Aging 25 1 5 18 14675724
  3. [4]Brun A Englund E 1986 A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study Ann Neurol 19 3 253 262 3963770
  4. [5]Bundgaard MJ Regeur L Gundersen HJ Pakkenberg B 2001 Size of neocortical neurons in control subjects and in Alzheimer’s disease J Anat 198 481 489 11327210 PMC1468234
  5. [7]Cotman CW Su JH 1996 Mechanisms of neuronal death in Alzheimer’s disease Brain Pathol 6 4 493 506 8944319
  6. [8]Daniel B DeCoster MA 2004 Quantification of sPLA2-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining Brain Res Brain Res Protoc 12 144 150 15296851
  7. [10]de Leeuw FE Barkhof F Scheltens P 2004 White matter lesions and hippocampal atrophy in Alzheimer’s disease Neurology 62 2 310 312 14745078
  8. [11]Desplats P Lee HJ Bae EJ Patrick C Rockenstein E Crews L Spencer B Masliah E Lee SJ 2009 Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein Proc Natl Acad Sci U S A 106 41 13010 13015 19651612 PMC2722313
  9. [12]Double KL Halliday GM McRitchie DA Reid WG Hely MA Morris JG 1996 Regional brain atrophy in idiopathic parkinson’s disease and diffuse Lewy body disease Dementia 7 6 304 313 8915036
  10. [13]Duyckaerts C Delatour B Potier MC 2009 Classification and basic pathology of Alzheimer disease Acta Neuropathol 118 5 36 19381658
  11. [14]Everall IP DeTeresa R Terry R Masliah E 1997 Comparison of two quantitative methods for the evaluation of neuronal number in the frontal cortex in Alzheimer disease J Neuropathol Exp Neurol 56 11 1202 1206 9370230
  12. [15]Gong Y Lippa CF 2010 Disruption of the postsynaptic density in Alzheimer’s disease and other neurodegenerative dementias AM J ALZHEIMERS DIS OTHER DEMEN 25 7 547 555 20858652 PMC2976708
  13. [16]Hanson JC Lippa CF 2009 Lewy body dementia Int Rev Neurobiol 84 215 228 19501720
  14. [17]Higashi S Iseki E Yamamoto R Minegishi M Hino H Fujisawa K Togo T Katsuse O Uchikado H Furukawa Y Kosaka K Arai H 2007 Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer’s disease and dementia with Lewy bodies Brain Res 1184 284 294 17963732
  15. [18]Ihara M Polvikoski TM Hall R Slade JY Perry RH Oakley AE Englund E O’Brien JT Ince PG Kalaria RN 2010 Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodies Acta Neuropathol 119 579 589 20091409 PMC2849937
  16. [20]Kobayashi K Hayashi M Nakano H Fukutani Y Sasaki K Shimazaki M Koshino Y 2002 Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer’s disease Neuropathol Appl Neurobiol 28 3 238 251 12060348
  17. [21]Lee JE Park B Song SK Sohn YH Park HJ Lee PH 2010 A comparison of gray and white matter density in patients with Parkinson’s disease dementia and dementia with Lewy bodies using voxel-based morphometry Mov Disord 25 1 28 34 19908327
  18. [22]Lee JT Wheeler TC Li L Chin LS 2008 Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death Hum Mol Genet 17 6 906 917 18065497
  19. [23]Luckhaus C 2009 Cerebral grey and white matter changes in mild cognitive impairment and Alzheimer’s disease Eur J Neurol 16 438 439 19348619
  20. [24]Mace PD Riedl SJ 2010 Molecular cell death platforms and assemblies Curr Opin Cell Biol 22 6 828 836 20817427 PMC2993832
  21. [25]Maeda Y Solanky M Menonna J Chapin J Li W Dowling P 2001 Platelet-derived growth factor-alpha receptor-positive oligodendroglia are frequent in multiple sclerosis lesions Ann Neurol 49 6 776 785 11409430
  22. [26]Mann DM Yates PO Marcyniuk B 1985 Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer’s disease, senile dementia of Alzheimer type and Down’s syndrome in middle age J Neurol Sci 69 139 159 3162000
  23. [27]McKeith IG Dickson DW Lowe J Emre M O’Brien JT Feldman H Cummings J Duda JE Lippa C Perry EK Aarsland D Arai H Ballard CG Boeve B Burn DJ Costa D Del Ser T Dubois B Galasko D Gauthier S Goetz CG Gomez-Tortosa E Halliday G Hansen LA Hardy J Iwatsubo T Kalaria RN Kaufer D Kenny RA Korczyn A Kosaka K Lee VM Lees A Litvan I Londos E Lopez OL Minoshima S Mizuno Y Molina JA Mukaetova-Ladinska EB Pasquier F Perry RH Schulz JB Trojanowski JQ Yamada M 2005 Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium Neurology 65 12 1863 1872 16237129
  24. [28]Nakamura T Lipton SA 2010 Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases Apoptosis 15 11 1354 1363 20177970 PMC2978885
  25. [29]Okouchi M Ekshyyan O Maracine M Aw TY 2007 Neuronal apoptosis in neurodegeneration Antioxid Redox Signal 9 8 1059 1096 17571960
  26. [30]Regeur L 1999 Increasing loss of brain tissue with increasing dementia: a stereological study of post-mortem brains from elderly females Eur J Neurol 7 1 47 54 10809914
  27. [31]Rinne JO Paljärvi L Rinne UK 1987 Neuronal size and density in the nucleus basalis of Meynert in Alzheimer’s disease J Neurol Sci 79 67 76 3612173
  28. [32]Riudavets MA Iacono D Resnick SM O’Brien R Zonderman AB Martin LJ Rudow G Pletnikova O Troncoso JC 2007 Resistance to Alzheimer’s pathology is associated with nuclear hypertrophy in neurons Neurobiology of Aging 28 1484 1492 17599696 PMC2694127
  29. [33]Roth AD Ramírez G Alarcón R Von Bernhardi R 2005 Oligodendrocytes damage in Alzheimer’s disease: beta amyloid toxicity and inflammation Biol Res 38 381 387 16579521
  30. [34]Uyama N Uchihara T Mochizuki Y Nakamura A Takahashi R Mizutani T 2009 Selective nuclear shrinkage of oligodendrocytes lacking glial cytoplasmic inclusions in multiple system atrophy: a 3-dimensional volumetric study J Neuropathol Exp Neurol 68 10 1084 1091 19918120
  31. [35]Whitman GT Cotman CW 2004 Oligodendrocyte degeneration in AD Neurobiology of Aging 25 33 36 14675727
  32. [36]Wolswijk G 2000 Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis Brain 123 Pt 1 105 115 10611125

Cited by

Sorted by citations

Authors
Gagyi, E., Kormos, B., Castellanos, K. J., Valyi‐Nagy, K., Korneff, D., LoPresti, P., Woltjer, R., & Valyi‐Nagy, T.
Affiliations
  • University of Illinois Chicago (US)
  • Oregon Health & Science University (US)
ORCID
Venue
Brain Pathology
Publisher
Wiley
Published
2012-04-12
Volume
22
Issue
6
Pages
803-810
ISSN
  • 1015-6305 (ISSN-L)
  • 1750-3639
DOI
10.1111/j.1750-3639.2012.00595.x
PMC
PMC4181948
OpenAlex
W2103289155
Cited by
38
References
4
Citations by year
2026: 2 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Brain Pathology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Rosztoczy Foundation
  • National Institute on Aging (P30AG008017)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, dementia with Lewy bodies, neurodegeneration, dementia pathogenesis, histopathology
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cell Nucleus, Female, Humans, Male, Oligodendroglia, Lewy Body Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review