Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease
Abstract
Morphometric analysis of standardized gross cerebral slices from 16 patients with end-stage Alzheimer's disease (AD), 14 controls without neuropathological lesions or neurological disease, and 4 neurologically intact nondemented patients with histopathological lesions of AD was used to measure cross-sectional areas of cerebral cortex, white matter, subcortical nuclei, and the ventricular system. In AD, there was global cerebral atrophy of both cortex and white matter, selective atrophy of the amygdala and hippocampus, and ex vacuo hydrocephalus. In addition, in half the cases of AD, white matter atrophy was associated with overt histopathological evidence of patchy rarefaction of fibers and gliosis. Patients with preclinical AD had prominent and selective shrinkage of white matter comparable to that observed in AD, yet their cortical areas were normal. These observations suggest that white matter degeneration is an intrinsic component of AD. Moreover, its presence in preclinical AD where cortical atrophy is not evident indicates that cytoskeletal abnormalities associated with axonal degeneration may precede and perhaps cause the cortical atrophy observed in clinically manifested AD.
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Previous neuroimaging and post-mortem brain studies have observed white matter alterations in the presence of minimal or only weak grey matter atrophy, suggesting that in principle white matter alterations in Alzheimer's disease are not dependent on grey matter atrophy.
“However, previous neuroimaging as well as post-mortem brain studies have observed white matter alterations in the presence of minimal or only weak grey matter atrophy (de la Monte, 1989; Zhuang et al., 2012), suggesting that in principle white matter alterations in Alzheimer’s disease are not dependent on grey matter atrophy.”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as de la Monte, 1989
Cites
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014 · see citing works
Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987 · see citing works
Rau, L. (1948) · The Lancet · doi:10.1016/s0140-6736(48)91789-9 · Cited by 826 · see citing works
The organization and some projections of cholinergic neurons of the mammalian forebrain
Fibiger, H. C. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90011-x · Cited by 818 · see citing works
Wilcock, G. K., & Esiri, M. M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90155-1 · Cited by 608 · see citing works
Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading
Brun, A., & Englund, E. M. (1981) · Histopathology · doi:10.1111/j.1365-2559.1981.tb01818.x · Cited by 566 · see citing works
Wilcock, G. K., Esiri, M. M., Bowen, D. M., & Smith, C. C. T. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90045-4 · Cited by 553 · see citing works
Cell loss in the locus coeruleus in senile dementia of Alzheimer type
Tomlinson, B. E., Irving, D., & Blessed, G. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90031-9 · Cited by 453 · see citing works
de la Monte, S. M., Vonsattel, J., & Richardson, E. P. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198809000-00003 · Cited by 434 · see citing works
Rogers, J., & Morrison, J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-10-02801.1985 · Cited by 410 · see citing works
Distribution of cerebral degeneration in Alzheimer's disease: A clinico-pathological study
Brun, A., & Gustafson, L. (1976) · Archiv f�r Psychiatrie und Nervenkrankheiten · doi:10.1007/bf00367450 · Cited by 397 · see citing works
Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
Yamamoto, T., & Hirano, A. (1985) · Annals of Neurology · doi:10.1002/ana.410170608 · Cited by 338 · see citing works
Alzheimer's disease: a correlative study.
Neary, D., Snowden, J. S., Mann, D. M. A., Bowen, D. M., Sims, N. R., Northen, B., Yates, P. O., & DAVISON, A. N. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.3.229 · Cited by 277 · see citing works
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90129-7 · Cited by 240 · see citing works
Disproportionate Atrophy of Cerebral White Matter in Chronic Alcoholics
de la Monte, S. M. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520330076013 · Cited by 231 · see citing works
A quantitative study of cerebral atrophy in old age and senile dementia
Hubbard, B. M., & Anderson, J. M. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90048-4 · Cited by 223 · see citing works
Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone
Hyman, B. T., Hoesen, G. W. V., & Damásio, A. R. (1987) · Annals of Neurology · doi:10.1002/ana.410220110 · Cited by 219 · see citing works
ULRICH, J. (1985) · Annals of Neurology · doi:10.1002/ana.410170309 · Cited by 211 · see citing works
The noradrenergic system in Alzheimer and multi-infarct dementias.
Mann, D., Yates, P. O., & Hawkes, J. (1982) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.45.2.113 · Cited by 185 · see citing works
Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging
Rezek, D. L., Morris, J. C., Fulling, K. H., & Gado, M. H. (1987) · Neurology · doi:10.1212/wnl.37.8.1365 · Cited by 173 · see citing works
Ultrasound contrast enhancing agents in neurosonology: principles, methods,future possibilities
Droste, D. W., Kaps, M., Navabi, D. G., & Ringelstein, E. B. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.102001001.x · Cited by 163 · see citing works
Verteilungsmuster der senilen Ver�nderungen im Gehirn
Jamada, M., & Mehraein, P. (1968) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00340827 · Cited by 92 · see citing works
Duyckaerts, C. J., Hauw, J., Piette, F., Rainsard, C., Poulain, V., Berthaux, P., & Escourolle, R. (1985) · Acta Neuropathologica · doi:10.1007/bf00698298 · Cited by 89 · see citing works
Alzheimer's disease: neuropathological correlates of cognitive and motor disorders
Mölsä, P. K., Säkö, E., Paljärvi, L., Rinne, J. O., & Rinne, U. K. (1987) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1987.tb05465.x · Cited by 68 · see citing works
Frontal lobe degeneration of non-Alzheimer type. IV. White matter changes
Englund, E. M., & Brun, A. (1987) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(87)90024-0 · Cited by 54 · see citing works
A comparison of nerve cell loss in cortical and subcortical structures in Alzheimer's disease.
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.3.310 · Cited by 45 · see citing works
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Sorted by citations
15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726 · see citing works
Alzheimer’s disease is type 3 diabetes—Evidence reviewed
de la Monte, S. M., & Wands, J. R. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200619 · Cited by 1,158 · see citing works
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
Aggregation of vascular risk factors and risk of incident Alzheimer disease
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790 · see citing works
Association of diabetes mellitus and dementia, the Rotterdam study
Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. B. (1996) · Diabetologia · doi:10.1007/s001250050588 · Cited by 677 · see citing works
Hippocampal formation glucose metabolism and volume losses in MCI and AD
De Santi, S., de Leon, M. J., Rusinek, H., Convit, A., Tarshish, C. Y., Roche, A., Tsui, W. H., Kandil, E., Boppana, M., Daisley, K., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00230-5 · Cited by 548 · see citing works
Pakkenberg, B. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00151-1 · Cited by 485 · see citing works
Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer’s disease
Lester-Coll, N., Rivera, E. J., Soscia, S. J., Doiron, K., Wands, J. R., & de la Monte, S. M. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9102 · Cited by 467 · see citing works
Early diagnosis of alzheimer’s disease: contribution of structural neuroimaging
Chételat, G., & Baron, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(02)00026-5 · Cited by 442 · see citing works
Cortical Change in Alzheimer's Disease Detected with a Disease-specific Population-based Brain Atlas
Thompson, P. M., Mega, M. S., Woods, R. P., Zoumalan, C. I., Lindshield, C., Blanton, R. E., Moussai, J., Holmes, C. J., Cummings, J. L., & Toga, A. W. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.1.1 · Cited by 438 · see citing works
Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease
De Leon, M. J., George, A. E., Golomb, J., Tarshish, C., Convit, A., Kluger, A., De Santi, S., Mc Rae, T., Ferris, S. H., Reisberg, B., et al. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00213-8 · Cited by 429 · see citing works
Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease
Convit, A., De Leon, M. J., Tarshish, C., De Santi, S., Tsui, W., Rusinek, H., & George, A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00001-8 · Cited by 427 · see citing works
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Korte, N., Nortley, R., & Attwell, D. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02215-w · Cited by 343 · see citing works
de la Monte, S. M., Tong, M., Lester-Coll, N. H., Plater, M. E., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10113 · Cited by 324 · see citing works
Hippocampal Atrophy in Normal Aging
Golomb, J. B. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540090066012 · Cited by 323 · see citing works
The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation.
de Leon, M. J., Golomb, J. B., GEORGE, A. E., Convit, A. J., Tarshish, C. Y., McRae, T., Santi, S. D., Smith, G. S., Ferris, S. H., & Noz, M. E. (1993) · PubMed Central · Cited by 322 · see citing works
Meta-analysis of amyloid-cognition relations in cognitively normal older adults
Hedden, T., Oh, H., Younger, A. P., & Patel, T. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828ab35d · Cited by 320 · see citing works
Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
de la Monte, S. M., Sohn, Y. K., & Wands, J. R. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00131-7 · Cited by 307 · see citing works
Westlake, T. M., Howlett, A., Bonner, T., Matsuda, L., & Herkenham, M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90511-8 · Cited by 290 · see citing works
A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons
Micheva, K. D., Wolman, D. N., Mensh, B. D., Pax, E., Buchanan, J., Smith, S. J., & Bock, D. D. (2016) · eLife · doi:10.7554/elife.15784 · Cited by 282 · see citing works
Goodenowe, D. B., Cook, L. L., Liu, J., Lu, Y., Jayasinghe, D., Ahiahonu, P. W. K., Heath, D., Yamazaki, Y., Flax, J., Krenitsky, K. F., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.p700023-jlr200 · Cited by 253 · see citing works
Small Vessel Disease and Alzheimer’s Dementia: Pathological Considerations
Kalaria, R. N. (2002) · Cerebrovascular Diseases · doi:10.1159/000049150 · Cited by 243 · see citing works
Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
de la Monte, S. M., Luong, T., Neely, T. R., Robinson, D., & Wands, J. R. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780140 · Cited by 227 · see citing works
MRI and CSF studies in the early diagnosis of Alzheimer's disease
de Leon, M. J., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Segal, S., Clark, C. M., Kerkman, D. J., DeBernardis, J. F., Li, J., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01381.x · Cited by 221 · see citing works
Oster‐Granite, M. L., McPhie, D. L., Greenan, J., & Neve, R. L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06732.1996 · Cited by 202 · see citing works
Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer's Disease
de Leon, M. J., Mosconi, L., Blennow, K., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Tsui, W., Louis, L. A. S., Sobanska, L., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.012 · Cited by 198 · see citing works
Functional Imaging of Visuospatial Processing in Alzheimer's Disease
Prvulovic, D., Hubl, D., Sack, A. T., Melillo, L., Maurer, K., Frölich, L., Lanfermann, H., Zanella, F., Goebel, R., Linden, D. E. J., et al. (2002) · NeuroImage · doi:10.1006/nimg.2002.1271 · Cited by 200 · see citing works
Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis
Papadopoulos, D., Dukes, S., Patel, R., Nicholas, R., Vora, A., & Reynolds, R. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00177.x · Cited by 192 · see citing works
The Blood‐Brain Barrier and Cerebrovascular Pathology in Alzheimer's Disease
Kalaria, R. N. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07821.x · Cited by 194 · see citing works
Focal demyelination in Alzheimer’s disease and transgenic mouse models
Mitew, S., Kirkcaldie, M. T. K., Halliday, G. M., Shepherd, C. E., Vickers, J. C., & Dickson, T. C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0657-2 · Cited by 186 · see citing works
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
Araque Caballero, M. Á., Suárez-Calvet, M., Duering, M., Franzmeier, N., Benzinger, T., Fagan, A. M., Bateman, R. J., Jack, C. R., Levin, J., Dichgans, M., et al. (2018) · Brain · doi:10.1093/brain/awy229 · Cited by 179 · see citing works
“…as well as post-mortem brain studies have observed white matter alterations in the presence of minimal or only weak grey matter atrophy (de la Monte, 1989; Zhuang et al., 2012), suggesting that in principle white matter alterations in Alzheimer’s disease are not de- pendent on grey matter…”
BackgroundRegeur, L., Jensen, G. B., Pakkenberg, H., Evans, S. M., & Pakkenberg, B. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90030-2 · Cited by 168 · see citing works
Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation
Stirling, D. P., & Stys, P. K. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.02.002 · Cited by 163 · see citing works
Freeborough, P. A., Woods, R. P., & Fox, N. C. (1996) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199611000-00030 · Cited by 158 · see citing works
Skoog, I. G., Hesse, C., Aevarsson, Ó., Landahl, S., Wahlström, J., Fredman, P., & Blennow, K. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.1.37 · Cited by 143 · see citing works
Hippocampal atrophy in early Alzheimer's Disease: Anatomic specificity and validation
Convit, A., de Leon, M. D., Golomb, J., George, A., Tarshish, C., Bobinski, M., Tsui, W., Santi, S. D. D., Wegiel, J., & Wiśniewski, H. (2005) · Psychiatric quarterly · doi:10.1007/bf01064929 · Cited by 81 · see citing works
Sub-regional hippocampal injury is associated with fornix degeneration in Alzheimer’s disease.
Lee, D. Y., Fletcher, E., Carmichael, O. T., Singh, B., Mungas, D., Reed, B., Martinez, O., Buonocore, M. H., Persianinova, M., & DeCarli, C. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00001 · Cited by 137 · see citing works
Is Alzheimer’s a disease of the white matter?
Sachdev, P. S., Zhuang, L., Braidy, N., & Wen, W. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835ed6e8 · Cited by 137 · see citing works
Zhuang, L., Sachdev, P. S., Trollor, J. N., Reppermund, S., Kochan, N. A., Brodaty, H., & Wen, W. X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058887 · Cited by 136 · see citing works
Contribution of Structural Neuroimaging to the Early Diagnosis of Alzheimer’s Disease
de Leon, M. J., Convit, A. J., DeSanti, S., Carroll, R., GEORGE, A. E., Rusinek, H., Bobinski, M., Wı́sniewski, H. M., & Louis, L. A. S. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004900 · Cited by 135 · see citing works
Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
Roth, A. D., Ramírez, G., Alarcón, R., & Rommy von Bernhardi, M. (2005) · Biological Research · doi:10.4067/s0716-97602005000400011 · Cited by 131 · see citing works
Pathology of Alzheimer's Disease
Blass, J. P., Ko, B., & Wisniewski, H. M. (1991) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30315-0 · Cited by 132 · see citing works
Cognitive decline strongly correlates with cortical atrophy in Alzheimer’s dementia
Mouton, P. R., Martin, L. J., Calhoun, M. E., Forno, G. D., & Price, D. L. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00080-3 · Cited by 128 · see citing works
Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI
Zhuang, L., Sachdev, P. S., Trollor, J. N., Kochan, N. A., Reppermund, S., Brodaty, H., & Wen, W. (2012) · Neurology · doi:10.1212/wnl.0b013e3182661f4d · Cited by 125 · see citing works
Cullum, S. J., Huppert, F. A., McGee, M., Dening, T., Ahmed, A., Paykel, E. S., & Brayne, C. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/1099-1166(200009)15:9 · Cited by 1 · see citing works
Change in retinal structural anatomy during the preclinical stage of Alzheimer's disease
Santos, C. Y., Johnson, L. N., Sinoff, S. E., Festa, E. K., Heindel, W. C., & Snyder, P. J. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.01.003 · Cited by 124 · see citing works
The relationship between blood pressure and dementia: a review
Skoog, I. G. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)89428-0 · Cited by 119 · see citing works
Kozachuk, W. E. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120050009 · Cited by 119 · see citing works
Murphy, D., Decarli, C., Daly, E., Gillette, J., Mcintosh, A. R., Haxby, J., Teichberg, D., Schapiro, M., Rapoport, S., & Horwitz, B. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90153-5 · Cited by 125 · see citing works
White matter lesion in the elderly
Meyer, J. S., Kawamura, J., & Terayama, Y. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90002-3 · Cited by 116 · see citing works
Kobayashi, K., Hayashi, M., Nakano, H., Fukutani, Y., Sasaki, K., Shimazaki, M., & Koshino, Y. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00390.x · Cited by 110 · see citing works
Free Water in White Matter Differentiates MCI and AD From Control Subjects
Dumont, M., Roy, M., Jodoin, P., Morency, F. C., Houde, J., Xie, Z., Bauer, C., Samad, T. A., Dijk, K. R. A. V., Goodman, J. A., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00270 · Cited by 108 · see citing works
Zhan, X., Jickling, G. C., Ander, B. P., Stamova, B. S., Liu, D., Kao, P. F., Zelin, M. A., Jin, L., DeCarli, C. S., & Sharp, F. R. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142013 · Cited by 102 · see citing works
de la Monte, S. M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111727 · Cited by 101 · see citing works
Metabolic Alterations Associated to Brain Dysfunction in Diabetes
Duarte, J. M. N. (2014) · Aging and Disease · doi:10.14336/ad.2014.1104 · Cited by 104 · see citing works
Amygdala cell loss and atrophy in Alzheimer's disease
Scott, S. A., Sparks, D. L., Scheff, S. W., DeKosky, S. T., & Knox, C. A. (1992) · Annals of Neurology · doi:10.1002/ana.410320412 · Cited by 100 · see citing works
Structural Magnetic Resonance Imaging in Established and Prodromal Alzheimer Disease: A Review
Atiya, M., Hyman, B. T., Albert, M., & Killiany, R. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200307000-00010 · Cited by 96 · see citing works
Cognitive reserve, cortical plasticity and resistance to Alzheimer's disease
Esiri, M. M., & Chance, S. A. (2012) · Alzheimer's Research & Therapy · doi:10.1186/alzrt105 · Cited by 95 · see citing works
Tong, M., Dong, M., & de la Monte, S. M. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-0995 · Cited by 96 · see citing works
Neuropathological distinction between Parkinson's dementia and Parkinson's plus Alzheimer's disease
de la Monte, S. M., Wells, S. E., Hedley‐Whyte, E. T., & Growdon, J. H. (1989) · Annals of Neurology · doi:10.1002/ana.410260302 · Cited by 95 · see citing works
Reduced temporal lobe blood flow in Alzheimer's disease.
Eberling, J., Jagust, W., Reed, B., & Baker, M. G. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90076-a · Cited by 99 · see citing works
Bendlin, B. B., Carlsson, C. M., Johnson, S. C., Zetterberg, H., Blennow, K., Willette, A. A., Okonkwo, O. C., Sodhi, A., Ries, M. L., Birdsill, A. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037720 · Cited by 91 · see citing works
A Review on Blood Pressure and Ischaemic White Matter Lesions
Skoog, I. G. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051184 · Cited by 92 · see citing works
In Vivo Structural Studies of the Hippocampus in Normal Aging and in Incipient Alzheimer's Diseasea
de Leon, M. J., Convit, A. J., GEORGE, A. E., Golomb, J. B., Santi, S. D., Tarshish, C. Y., Rusinek, H., Bobinski, M., INCE, C., MILLER, D., et al. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34395.x · Cited by 88 · see citing works
Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss.
House, M. J., Pierre, T. G. S., Foster, J. K., Martins, R. N., & Clarnette, R. (2006) · PubMed Central · Cited by 87 · see citing works
Adluru, N., Destiche, D. J., Lu, S. Y.-F., Doran, S. T., Birdsill, A. C., Melah, K. E., Okonkwo, O. C., Alexander, A. L., Dowling, N. M., Johnson, S. C., et al. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.04.008 · Cited by 85 · see citing works
Executive Dysfunction in MCI: Subtype or Early Symptom
Reinvang, I., Grambaitė, R., & Espeseth, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/936272 · Cited by 85 · see citing works
Skoog, I. G., Palmertz, B., & Andreasson, L. (1994) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879400700308 · Cited by 82 · see citing works
Neocortical Glial Cell Numbers in Alzheimer’s Disease
Pelvig, D. P., Pakkenberg, H., Regeur, L., Oster, S., & Pakkenberg, B. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000072805 · Cited by 81 · see citing works
Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease
Zhan, X., Jickling, G. C., Ander, B. P., Liu, D., Stamova, B. S., Cox, C. D., Jin, L. W., DeCarli, C. S., & Sharp, F. R. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140131120922 · Cited by 79 · see citing works
Collins-Praino, L. E., Francis, Y. I., Griffith, E. Y., Wiegman, A. F., Urbach, J., Lawton, A., Honig, L. S., Cortes, E., Vonsattel, J. P. G., Canoll, P. D., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0083-0 · Cited by 79 · see citing works
Stereological quantification of the cerebellum in patients with Alzheimer's disease
Andersen, K., Andersen, B. B., & Pakkenberg, B. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.013 · Cited by 78 · see citing works
Deochand, M. T. C. (2013) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000128 · Cited by 77 · see citing works
de la Monte, S. M., Tong, M., Schiano, I., & Didsbury, J. R. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160656 · Cited by 76 · see citing works
Hyman, B. T., & Gómez‐Isla, T. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90031-0 · Cited by 76 · see citing works
Alzheimer’s disease and the fornix
Oishi, K., & Lyketsos, C. G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00241 · Cited by 74 · see citing works
The topographic distribution of brain atrophy in Alzheimer's disease
Mann, D. M. A. (1991) · Acta Neuropathologica · doi:10.1007/bf00294434 · Cited by 74 · see citing works
Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease
ETIENNE, D., Kraft, J., Ganju, N., Gómez‐Isla, T., Gemelli, B., Hyman, B. T., Hedley‐Whyte, E. T., Wands, J. R., & de la Monte, S. M. (1998) · Journal of Alzheimer s Disease · doi:10.3233/jad-1998-1205 · Cited by 73 · see citing works
Relationships Between Diabetes and Cognitive Impairment
de la Monte, S. M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.006 · Cited by 71 · see citing works
Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo.
Jantaratnotai, N., Ryu, J. K., Kim, S. U., & McLarnon, J. G. (2003) · PubMed · doi:10.1097/00001756-200308060-00005 · Cited by 71 · see citing works
Sun, X.-H., Dong, Y.-X., Zhang, H.-Y., Li, H.-Y., Liu, P.-H., & Sui, Y. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.232486 · Cited by 67 · see citing works
Cognitive correlates of cerebral white matter changes
de Groot, J. C., de Leeuw, F., & Breteler, M. M. B. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_5 · Cited by 66 · see citing works
Lasaponara, S., Marson, F., Doricchi, F., & Cavallo, M. (2021) · Brain Science · doi:10.3390/brainsci11050528 · Cited by 54 · see citing works
Executive Function: The Core Feature of Dementia?
Voss, S. E., & Bullock, R. A. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000079202 · Cited by 66 · see citing works
Aberrant GAP-43 gene expression in Alzheimer's disease.
de la Monte, S. M., Ng, S., & Hsu, D. (1995) · Europe PMC (PubMed Central) · Cited by 66 · see citing works
Cantero, J. L., Atienza, M., Lage, C., Záborszky, L., Vilaplana, E., López‐García, S., Pozueta, A., Rodríguez‐Rodríguez, E., Blesa, R., Alcolea, D. A., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz224 · Cited by 65 · see citing works
Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain.
Nishimura, M., Tomimoto, H., Suenaga, T., Namba, Y., Ikeda, K., Akiguchi, I., & Kimura, J. (1995) · Europe PMC (PubMed Central) · Cited by 65 · see citing works
Matsumae, M., Kikinis, R., Mórocz, I. Á., Lorenzo, A. V., Albert, M., Black, P. M., & Jolesz, F. A. (1996) · Journal of neurosurgery · doi:10.3171/jns.1996.84.6.0972 · Cited by 64 · see citing works
Barra, V., & Boire, J. Y. (2000) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(200003)11:3 · Cited by 63 · see citing works
Structural Magnetic Resonance Image Averaging in Schizophrenia
Wolkin, A., Rusinek, H., Vaid, G., Arena, L., Lafargue, T., Sanfilipo, M. P., Loneragan, C., Lautin, A., & Rotrosen, J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1064 · Cited by 60 · see citing works
Cingulum fiber diffusivity and CSF T-tau in patients with subjective and mild cognitive impairment
Stenset, V. T. V., Bjørnerud, A., Fjell, A. M., Walhovd, K. B., Hofoss, D., Due‐Tønnessen, P., Gjerstad, L., & Fladby, T. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.014 · Cited by 61 · see citing works
de la Monte, S. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_4 · Cited by 59 · see citing works
THE HIPPOCAMPUS IN AGING AND ALZHEIMER'S DISEASE
de Leon, M. J., Convit, A. J., DeSanti, S., Golomb, J. B., Tarshish, C. Y., Rusinek, H., Bobinski, M., Ince, C., Miller, D. C., Wı́sniewski, H. M., et al. (1995) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00272-2 · Cited by 59 · see citing works
Clinical correlates of high signal lesions on magnetic resonance imaging in Alzheimer's disease
Bennett, D. A., Gilley, D. W., Wilson, R. S., Huckman, M. S., & Fox, J. H. (1992) · Journal of Neurology · doi:10.1007/bf00839137 · Cited by 58 · see citing works
Hypertension and Related Factors in the Etiology of Alzheimer's Disease
Skoog, I. G., & Gustafson, D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04796.x · Cited by 57 · see citing works
Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer’s disease
Gao, Y., Sengupta, A., Li, M., Zu, Z., Rogers, B. P., Anderson, A. W., Ding, Z., Gore, J. C., & Initiative, A. D. N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240513 · Cited by 57 · see citing works
Harrison, P. J., PROCTER, A. W., Exworthy, T., Roberts, G. W., Najlerahim, A., BARTON, A. J. L., & Pearson, R. C. A. (1993) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1993.tb00400.x · Cited by 54 · see citing works
Lyros, E., Ragoschke-Schumm, A., Kostopoulos, P., Sehr, A., Backens, M., Kalampokini, S., Decker, Y., Lesmeister, M., Liu, Y., Reith, W., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.11.012 · Cited by 48 · see citing works
Park, S., Bak, A.-R., Kim, S., Nam, Y., Kim, H. S., Yoo, D., & Moon, M. (2020) · Biomedicines · doi:10.3390/biomedicines8060150 · Cited by 48 · see citing works
de la Monte, S. M., Volicer, L., Hauser, S. L., & Wands, J. R. (1992) · Annals of Neurology · doi:10.1002/ana.410320606 · Cited by 50 · see citing works
- Authors
- de la Monte, S. M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1989-05
- Volume
- 25
- Issue
- 5
- Pages
- 450-459
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2062125611
- Cited by
- 229
- References
- 33
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 9
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG05134-03)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, brain atrophy, preclinical Alzheimer's disease, white matter atrophy, cortical atrophy, hippocampal atrophy, amygdala atrophy, gliosis, axonal degeneration, cytoskeletal abnormalities, brain ventricles, subcortical nuclei
- MeSH terms
- Alzheimer Disease, Atrophy, Humans
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