The humoral response in natural Dirofilaria immitis infections in dogs
Abstract
SUMMARY Plasma samples from dogs with infections of Dirofilaria Immitis were assessed using ELISA and Western blotting techniques. These results were then assessed in relation to age and sex of the host, and to the numbers of microfilariae and adult filariae. Dogs with microfilariae tended to have lower levels of infection. In infected dogs, mean ELISA titres increased directly with the degree of infection. Dogs that were either young or mildly infected, showed a preferential antibody reactivity to antigens in the high molecular weight regions of the immunoblots. With increasing age and/or the extent of infection, an antibody response to antigens in the low molecular weight regions was apparent.
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Antibody responses increase after treatment with adulticides.
“An increase in antibody responses after treatment with adulticides has been reported (416)”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [416]
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Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-12 · Cited by 834 · see citing works
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- Authors
- TANAKA, K., & ATWELL, R.
- Affiliations
- The University of Queensland (AU)
- Venue
- Australian Veterinary Journal
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 68
- Issue
- 12
- Pages
- 396-399
- ISSN
- 0005-0423 (ISSN-L)
- 1751-0813
- OpenAlex
- W2042071819
- Cited by
- 5
- References
- 10
- Citations by year
- 2023: 1 · 2020: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian Veterinary Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Anhui University of Science and Technology
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- Dirofilaria immitis, canine heartworm disease, humoral immune response, antibody titers, microfilariae, infection intensity, age and sex effects, antigen reactivity, dogs
- MeSH terms
- Age Factors, Animals, Antibodies, Helminth, Dirofilaria immitis, Dirofilariasis, Dog Diseases, Dogs, Enzyme-Linked Immunosorbent Assay, Female, Male, Microfilariae, Queensland, Sex Factors, Blotting, Western, Prevalence
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