The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Mechanism of Photofrin Photobleaching and Its Consequences for Photodynamic Dosimetry
Abstract
Abstract— We report experimental results that support a theory of self‐sensitized singlet oxygen‐mediated bleaching of the porphyrin photosensitizer Photofrin. Microelectrode measurements of photodynamic oxygen consumption were made near the surface of individual, Photofrin‐sensitized EMT6 spheroids during laser irradiation. The progressive decrease in photochemical oxygen consumption with sustained irradiation is consistent with a theory in which bleaching occurs via self‐sensitized singlet oxygen reaction with the photosensitizer ground state. A bleaching model based solely on absorbed optical energy density is inconsistent with the data. Photobleaching has a significant effect on calculated photodynamic dose distributions in 500 pin diameter spheriods. Dose distributions corrected for the effects of bleaching produce a new estimate (12.1 ± 1.2 m M) for the threshold dose of reacting singlet oxygen in this system.
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Cites
Oxygen Consumption and Diffusion Effects in Photodynamic Therapy
Foster, T. H., Murant, R. S., Bryant, R. G., Knox, R. S., Gibson, S. L., & Hilf, R. (1991) · Radiation Research · doi:10.2307/3577919 · Cited by 400
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Cited by
Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., & Peng, Q. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.12.889 · Cited by 4,716
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., Pogue, B. W., & Hasan, T. (2010) · Chemical Reviews · doi:10.1021/cr900300p · Cited by 2,324
Implicit and explicit dosimetry in photodynamic therapy: a New paradigm
Wilson, B. C., Patterson, M. S., & Lilge, L. (1997) · Lasers in Medical Science · doi:10.1007/bf02765099 · Cited by 411
Metadata
- Authors
- Georgakoudi, I., Nichols, M. G., & Foster, T. H.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1997-01
- Volume
- 65
- Issue
- 1
- Pages
- 135-144
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2076285867
- Cited by
- 228
- References
- 1
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Georgakoudi, I., Nichols, M. G., & Foster, T. H. (1997). The Mechanism of Photofrin Photobleaching and Its Consequences for Photodynamic Dosimetry. Photochemistry and Photobiology. https://doi.org/10.1111/j.1751-1097.1997.tb01889.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
