α‐Tocopherol, an Inhibitor of Epidermal Lipid Peroxidation, Prevents Ultraviolet Radiation from Suppressing the Skin Immune System
Abstract
We investigated the involvement of epidermal lipid peroxidation in the induction of ultraviolet radiation (UVR)-induced suppression of the skin immune system. The shaved dorsal skin of C3H/HeJ mice was irradiated with one of two subinflammatory solar-simulated UVR protocols 3 days per week for 4 weeks. Then half of 1 mg, 1, 2.5 or 5 mg alpha-tocopherol in a vehicle of acetone was topically applied to the shaved dorsal skin before UVR, A 5 mg dose of vitamin E gave complete protection against a UVR protocol that induced a 55% reduction in the contact hypersensitivity response to 2,4,6-trinitrochlorobenzene and a 23% reduction in epidermal Langerhans cell density. Lower doses were ineffective. alpha-Tocopherol was unable to protect against a higher UVR protocol. As 5 mg alpha-tocopherol did not prevent postirradiation inflammatory edema it is unlikely that the antioxidant acted as a sunscreen. However, 5 mg alpha-tocopherol inhibited UVR-induced epidermal lipid peroxidation, suggesting that this may be one mechanism by which alpha-tocopherol prevented UVR-induced local immunosuppression. Scavenging of UVR-generated lipid peroxides and reactive oxygen may have inhibited loss of cell membrane integrity preventing depletion of LC numbers, thus protecting from local immunosuppression.
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Vitamin E protects against immunosuppression.
“| | | Immunosuppression | | + | (110) |”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [110]
Cites
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Cutaneous photodamage, oxidative stress, and topical antioxidant protection
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UV photoprotection by combination topical antioxidants vitamin C and vitamin E
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Photoprotection: a Review of the Current and Future Technologies
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- Authors
- Yuen, K. S., & Halliday, G. M.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Halliday, Gary M.
- ORCID
- Halliday, Gary M.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1997-03
- Volume
- 65
- Issue
- 3
- Pages
- 587-592
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2095375349
- Cited by
- 102
- References
- 1
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 3 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- alpha-tocopherol, vitamin E, ultraviolet radiation, skin immune system, immunosuppression, Langerhans cells, contact hypersensitivity, 2,4,6-trinitrochlorobenzene, topical antioxidants, reactive oxygen species, plasma membrane integrity
- MeSH terms
- Animals, Female, Mice, Inbred C3H, Skin, Ultraviolet Rays, Vitamin E, Lipid Peroxidation, Mice
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