The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Early Events in UV Carcinogenesis—DNA Damage, Target Cells and Mutant p53 Foci†
Open accessAbstract
Skin carcinomas are the most common cancers in fair‐skinned populations of North West European descent. The risk is closely related to sun (UV) exposure and susceptibility to sunburn. Induction of squamous cell carcinomas (SCCs) in the skin of hairless mice by daily UVB exposure appears to emulate the genesis of these tumors in humans quite well. The carcinomas, and the UVB signature mutations that they carry in their p53 genes, can be linked most specifically to the induction of cyclobutane pyrimidine dimers (CPDs). The wavelength dependence of the induction of carcinomas parallels that of CPD induction over the UVB and UVA2 spectral regions. Microscopic clusters of cells overexpressing p53 with UVB signature mutations (“p53 patches”) can be detected in the interfollicular epidermis long before the skin tumors arise. DNA repair—more precisely nucleotide excision repair—is a crucial line of defense against UV‐induced p53 patches and skin carcinomas. Although chemoprevention of UV carcinogenesis, e.g. with difluoromethylornithine, may be successful by inhibiting the outgrowth of tumors, it may be better to counter the initial steps in tumor development. As the p53 patches appear to be potential precursors of SCCs, regression of p53 patches in unexposed skin should lower subsequent development of SCCs. However, “holoclonal” p53 patches might persist. Ablation of the interfollicular epidermis would be expected to abrogate development of SCC, and negation of this expectation [Faurschou A. et al., Exp. Dermatol. 2007;16:485–489] would indicate that SCCs stem from deep‐seated cells in the hair follicles. Careful examination of archival material showed that although most small p53 patches arise interfollicularly, some may actually arise high up in a follicle, in the infundibulum.
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“It is now well documented that DNA is the main critical cellular macromolecule for determining the carcinogenic effects of solar radiation (7)(8)(9).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [8]
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“with the observation of UVB-induced C fi T transition and CC fi TT mutations at bipyrimidine sites in p53 genes of skin tumors (8,15).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [8]
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A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma
Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10124 · Cited by 1,959
INCIDENCE OF SKIN CANCER AFTER RENAL TRANSPLANTATION IN THE NETHERLANDS
HARTEVELT, M. M., Bavinck, J. N. B., KOOTTE, A. M. M., Vermeer, B. J., & Vandenbroucke, J. P. (1990) · Transplantation · doi:10.1097/00007890-199003000-00006 · Cited by 690
Frequent clones of p53-mutated keratinocytes in normal human skin
Jonason, A. S., Kunala, S., Price, G. J., Restifo, R. J., Spinelli, H. M., Persing, J. A., Leffell, D. J., Tarone, R. E., & Brash, D. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14025 · Cited by 685
Wavelength dependence of oxidative DNA damage induced by UV and visible light
Kielbassa, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.811 · Cited by 616
Skin cancer and solar UV radiation
de Gruijl, F. R. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00283-x · Cited by 601
Skin cancer is among the most costly of all cancers to treat for the Medicare population
Housman, T. S., Feldman, S. R., Williford, P. M., Fleischer, A. B., Goldman, N. D., Acostamadiedo, J. M., & Chen, G. J. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.186 · Cited by 490
Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice.
de Gruijl, F. R., Sterenborg, H. J. C. M., Forbes, P. D., Davies, R. E., Cole, C. A., Kelfkens, G., van Weelden, H., Slaper, H., & van der Leun, J. C. (1993) · PubMed · Cited by 471
UV-induced mutation hotspots occur at DNA damage hotspots
Brash, D. E., & Haseltine, W. A. (1982) · Nature · doi:10.1038/298189a0 · Cited by 385
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition
Pentland, A. P., Schoggins, J. W., Scott, G., Khan, K. N. M., & Han, R. (1999) · Carcinogenesis · doi:10.1093/carcin/20.10.1939 · Cited by 328
Freeman, S. E., Hacham, H., Gange, R. W., Maytum, D. J., Sutherland, J. C., & Sutherland, B. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5605 · Cited by 311
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Rotta, L., Fuchs, V., Brestak, M., & Žižkovský, V. (1988) · PubMed
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Palla, V. (2019) · Dermatologie pro praxi · doi:10.36290/der.2019.010
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Dermabrasion, Laser Resurfacing, and Photorejuvenation for Prevention of Non-Melanoma Skin Cancer
Faurschou, A., & Hædersdal, M. (2009) · Springer eBooks · doi:10.1007/978-3-540-79341-0_25
Metadata
- Authors
- De Gruijl, F. R., & Rebel, H.
- Affiliations
- Leiden University Medical Center (NL)
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2008-01-23
- Volume
- 84
- Issue
- 2
- Pages
- 382-387
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2026711274
- Cited by
- 120
- References
- 69
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 14
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- UV carcinogenesis, cutaneous squamous cell carcinoma, TP53 mutation, cyclobutane pyrimidine dimers, nucleotide excision repair, DNA damage, hairless mice, difluoromethylornithine, chemoprevention, interfollicular epidermis, hair follicle infundibulum, tumor origin, sunburn
- MeSH terms
- Animals, DNA Damage, Humans, Mutation, Neoplasms, Radiation-Induced, Ultraviolet Rays, Tumor Suppressor Protein p53, Mice
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