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Cited by 15Dementia and Cognitive Impairment ResearchNutrition and Health in AgingAging and Gerontology Research

Functional expressions of the aging brain: Nutrition Reviews©, Vol. 68, No. s2

Folstein, Marshal, Folstein, Susan·2010·Nutrition Reviews
DOI 10.1111/j.1753-4887.2010.00351.x
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Abstract

In the conventional view, aging of the brain is associated with atrophy vascular abnormalities and loss of volume in hippocampus and amygdala. Cognitively, aging is associated with slowing of processing and memory loss. However, many studies of aging do not examine the cases to exclude demented people. The nutrition and memory in the homebound elderly study (NAME) excluded cases clinically diagnosed as having dementia. Cortical atrophy based on MRI ratings was significantly correlated with vascular disease, white matter hyperintensities, processing speed, and memory but not hippocampus and amygdala volume. Renal function and homocysteine were also associated with cortical atrophy but not with the cognitive variables. In conclusion, brain atrophy of aging in the absence of dementia is related to vascular disease but not hippocampal atrophy. Studies of nutritional interventions should consider using MRI atrophy rather than cognition as outcome.

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  • At least some elements of cognitive decline evolve throughout adulthood.

    “Lastly, it is worth noting that at least some elements of cognitive decline evolve throughout adulthood [195, 242-245].”

    From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [243]

  • These cognitive changes typically manifest at ages younger than those at which plaque deposition typically begins.

    “These changes typically manifest at ages younger than those at which plaque deposition typically begins.”

    From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [243]

  • Cognitive speed and multitasking abilities become less robust with advancing age.

    “Cognitive speed and multitasking abilities, for example, become less robust with advancing age.”

    From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [243]

  • Memory encoding, working memory, and processing speed decline with age; semantic knowledge and autobiographical memory tend to remain intact.

    “Memory encoding, working memory (a component of executive function), and processing speed all decline with age. Although this decline probably proceeds throughout adulthood it truly becomes evident after the age of 60. Semantic knowledge and autobiographical memory, on the other hand, tend to remain intact.”

    From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [17]

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Authors
Folstein, M., & Folstein, S.
Affiliations
Tufts University (US)
Corresponding author
Folstein, Marshal
Venue
Nutrition Reviews
Publisher
Oxford University Press (OUP)
Published
2010-11-23
Volume
68
Pages
S70-S73
ISSN
0029-6643 (ISSN-L)
DOI
10.1111/j.1753-4887.2010.00351.x
OpenAlex
W1553020976
Cited by
15
References
18
Citations by year
2024: 2 · 2020: 1 · 2018: 1 · 2013: 4 · 2012: 1
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords
brain aging, cortical atrophy, vascular disease, white matter hyperintensities, hippocampal atrophy, amygdala volume, memory loss, processing speed, renal function, homocysteine, dietary intervention
MeSH terms
Aged, Aged, 80 and over, Aging, Amygdala, Brain, Cognition Disorders, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nutritional Physiological Phenomena

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