The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Lithium: Still a Major Option in the Management of Bipolar Disorder
Open accessAbstract
SUMMARY: Still after more than 50 years, lithium is a major treatment of bipolar disorder, even though it has not been promoted by the pharmaceutical industry over the last decades. In recent years the evidence base on lithium for bipolar disorder has substantially increased due to results from a number of trials. Therefore, a review of this evidence is timely. The efficacy of lithium as an acute treatment and as a maintenance treatment of bipolar disorder was evaluated through a review of the evidence, focusing on modern, randomized, parallel‐group designed trials. Additionally, the evidence was sought translated into the proper use of lithium in clinical practice. Lithium's antimanic efficacy has been convincingly demonstrated. However, as blood monitoring due to the risk of toxicity is required and due to an insufficient response in highly agitated patients, lithium monotherapy has a limited place in the acute treatment of severe manic states. For acute bipolar depression, results are conflicting. Recent maintenance trials have added substantially to the documentation of lithium's long‐term stabilizing properties in bipolar disorder, and these properties have been demonstrated independently of any acute response to lithium. Finally, it is now beyond doubt that not only does lithium prevent mania, but also depression in bipolar disorder. Lithium is still to be considered a major if not the most important mood‐ stabilizer, at least for maintaining long‐term stability in patients with bipolar disorder. The potential risks of lithium should be weighed up against its benefits and the fact that serious adverse effects are usually avoidable.
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Cites
Bowden, C. L. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.481 · Cited by 678
Goodwin, G. M., Bowden, C. L., Calabrese, J. R., Grunze, H., Kasper, S., White, R., Greene, P., & Leadbetter, R. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0321 · Cited by 581 · cited 1×
“In a combined analysis of the two studies, lithium did statistically significantly better than lamotrigine in the prevention of mania, whereas lamotrigine did numerically (but not statistically significantly) better than lithium in the prevention of depression [53].”
Sachs, G. S., Grossman, F., Ghaemi, S. N., Okamoto, A., & Bowden, C. L. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1146 · Cited by 424
Grunze, H., Vieta, E., Goodwin, G. M., Bowden, C., Licht, R. W., Möller, H.-J., Kasper, S., & WFSBP Task Force On Treatment Guidelines For Bipolar Disorders (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903555881 · Cited by 399
Self-citationYoung, A. H., McElroy, S. L., Bauer, M., Philips, N., Chang, W., Olausson, B., Paulsson, B., Brecher, M., & EMBOLDEN I (Trial 001) Investigators (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04995gre · Cited by 390
Lithium Treatment and Risk of Dementia
Kessing, L. V., Søndergård, L., Forman, J. L., & Andersen, P. K. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1331 · Cited by 267
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Kane, J. M. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290090053011 · Cited by 212
Pattern of Response to Divalproex, Lithium, or Placebo in Four Naturalistic Subtypes of Mania
Swann, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00390-6 · Cited by 137
Cited by
Carvalho, A. F., Firth, J., & Vieta, E. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1906193 · Cited by 562
Grunze, H., Vieta, E., Goodwin, G. M., Bowden, C., Licht, R. W., Azorin, J.-M., Yatham, L., Mosolov, S., Möller, H.-J., Kasper, S., et al. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1384850 · Cited by 187
Self-citationLong-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres
Martinsson, L., Wei, Y., Xu, D., Melas, P. A., Mathé, A. A., Schalling, M., Lavebratt, C., & Backlund, L. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.37 · Cited by 179
Nolen, W. A., Licht, R. W., Young, A. H., Malhi, G. S., Tohen, M., Vieta, E., Kupka, R. W., Zarate, C., Nielsen, R. E., Baldessarini, R. J., et al. (2019) · Bipolar Disorders · doi:10.1111/bdi.12805 · Cited by 164
Self-citationLithium in the treatment of major depressive disorder
Bschor, T. (2014) · Drugs · doi:10.1007/s40265-014-0220-x · Cited by 94
Metadata
- Authors
- Licht, R. W.
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2011-06-23
- Volume
- 18
- Issue
- 3
- Pages
- 219-226
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- OpenAlex
- W2133809326
- Cited by
- 168
- References
- 10
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
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