Lithium in the treatment of major depressive disorder
Abstract
Recent high-quality studies have confirmed the central role of lithium in the treatment of bipolar disorder and have established lithium as the drug of first choice for long-term prophylaxis in this condition. However, several indications for its use in unipolar major depression are also based on sound evidence. This includes lithium augmentation as a main strategy for depressed patients not responding to an antidepressant, lithium prophylaxis for recurrent unipolar depression as an alternative to prophylaxis with an antidepressant, and lithium's unique anti-suicidal properties. Lithium monotherapy, on the other hand, is not established for acute treatment of depression. Lithium therapy should be a core competency of every psychiatrist, enabling the safe use of lithium, to the benefit of our patients.
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There is evidence of cost-effectiveness of iCBT in primary care settings.
“There is also evidence of cost-effectiveness in primary care settings, 626”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [626]
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- Authors
- Bschor, T.
- Affiliations
- Schlosspark-Klinik (DE)
- Corresponding author
- Bschor, Tom
- ORCID
- Bschor, Tom
- Venue
- Drugs
- Published
- 2014-05-14
- Volume
- 74
- Issue
- 8
- Pages
- 855-862
- ISSN
- 0012-6667 (ISSN-L)
- 1179-1950
- OpenAlex
- W1994511645
- Cited by
- 94
- References
- 56
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Drugs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- AstraZeneca
- H. Lundbeck A/S
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- lithium, major depressive disorder, bipolar disorder, lithium augmentation, antidepressant-resistant depression, depression prevention, suicide prevention, lithium monotherapy
- MeSH terms
- Suicide Prevention, Antidepressive Agents, Bipolar Disorder, Major Depressive Disorder, Humans, Lithium Compounds
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