The frequency of sicca symptoms and S jögren's syndrome in patients with systemic sclerosis
Abstract
Objective The objectives are to detect the frequency of sicca symptoms and Sjögren's syndrome (SS) in patients with systemic sclerosis (SSc) based on the diagnostic criteria of the American-European Consensus Group (AECG) and to evaluate demographic, clinical and serologic characteristics. Patients and method One hundred and eighteen SSc patients referred to our hospital were included in this study. All SSc patients were questioned with respect to sicca symptoms. Levels of rheumatoid factor (RF), anti-nuclear antibodies (ANA), anti-Ro and anti-La antibodies were measured; non-stimulated saliva amounts were recorded and Schirmer test and break-up time were applied to all patients. Minor salivary gland biopsy samples were obtained from those patients giving ≥ 3 positive answers to sicca symptom questions, patients with positive xerostomia/xerophthalmia test results, and patients with at least one antibody being positive. Patients presenting with grade 3 and/or grade 4 sialoadenitis based on Chisholm criteria were considered pathological. Results Sicca symptoms were present in 84 of 118 patients with SSc (71.2%). Minor salivary gland biopsy samples were obtained from 74 patients. Grade 3 and/or grade 4 sialoadenitis was detected in 40 (33.9%) patients and they were diagnosed with SS. Compared to patients diagnosed with SSc alone, systemic sclerosis patients diagnosed with SS had lower pulmonary hypertension and less diffuse lung involvement. Statistically significant difference…
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Several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis, HIV, and cystic fibrosis, also feature dysregulated salivary flow and altered oral microbial populations.
“Significantly, several diseases that share both disproportionately high rates of vascular disease and PH, including Sjögren's and systemic sclerosis[294–297], HIV[7,11], and cystic fibrosis[298] also feature dysregulated salivary flow[299–302] and altered oral microbial populations[224,303–306].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [297]
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- Authors
- Kobak, S., Oksel, F., Aksu, K., & Kabasakal, Y.
- Affiliations
- Department of Rheumatology Faculty of Medicine Şifa University Izmir Turkey
- Department of Rheumatology Faculty of Medicine Ege University Izmir Turkey
- Ege University (TR)
- Venue
- International Journal of Rheumatic Diseases
- Publisher
- Wiley
- Published
- 2012-08-31
- Volume
- 16
- Issue
- 1
- Pages
- 88-92
- ISSN
- 1756-1841 (ISSN-L)
- 1756-185X
- OpenAlex
- W2049636697
- Cited by
- 53
- References
- 19
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 10 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Keywords
- systemic sclerosis, Sjögren's syndrome, sicca symptoms, xerostomia, xerophthalmia, minor salivary gland biopsy, sialadenitis, anti-SSA antibodies, anti-SSB antibodies, anti-topoisomerase 1 antibodies, pulmonary hypertension, pulmonary involvement, telangiectasia, serological markers
- MeSH terms
- Female, Humans, Male, Middle Aged, Salivary Glands, Scleroderma, Systemic, Sjogren's Syndrome, Xerophthalmia, Xerostomia, Comorbidity, Incidence
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