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An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
Abstract
An in-vitro test system was developed to investigate the adhesiveness of various materials to mucus. The results obtained showed good agreement with the findings of previous in-vivo evaluations of mucosa-adhesives. Further investigations found that these materials become adhesive on hydration. Chain length, and the presence of ionizable groups in the molecule, were found to be determinate factors. The physical nature of the gel, and the location at which the mucoadhesive materials hydrated, were of less importance.
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Citations
Cited by
The basics and underlying mechanisms of mucoadhesion
SMART, J. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.001 · Cited by 1,167
Self-citationSurface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
Peppas, N. A., & Buri, P. A. (1985) · Journal of Controlled Release · doi:10.1016/0168-3659(85)90050-1 · Cited by 710
The biopharmaceutical aspects of nasal mucoadhesive drug delivery
Ugwoke, M. I., Verbeke, N., & Kinget, R. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011775145 · Cited by 355
PEGylated chitosan derivatives: Synthesis, characterizations and pharmaceutical applications
Casettari, L., Vllasaliu, D., Castagnino, E., Stolnik, S., Howdle, S., & Illum, L. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.10.001 · Cited by 232
Metadata
- Authors
- Smart, J. D., Kellaway, I. W., & Worthington, H. E. C.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-05-01
- Volume
- 36
- Issue
- 5
- Pages
- 295-299
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1988373919
- Cited by
- 467
- References
- 0
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. https://app.cochat.ai/papers/10.1111/j.2042-7158.1984.tb04377.x
- The paper
- Smart, J. D., Kellaway, I. W., & Worthington, H. E. C. (1984). An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1984.tb04377.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
