Cited by 139Advanced Drug Delivery SystemsHypothalamic control of reproductive hormonesHormonal and reproductive studies

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Controlled Release of LHRH Agonist, Leuprolide Acetate, from Microcapsules: Serum Drug Level Profiles and Pharmacological Effects in Animals

Ogawa, Yasuaki, Okada, Hiroaki, Heya, Toshiro, Shimamoto, Tsugio·1989·Journal of Pharmacy and Pharmacology

DOI 10.1111/j.2042-7158.1989.tb06497.x

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Abstract

The pharmacokinetic behaviour of leuprolide acetate from a controlled release parenteral dosage form has been studied in rats and dogs. The release of the drug in rats after a single subcutaneous injection exhibited pseudo-zero-order kinetics for one month in doses ranging from 0.0135 to 1.35 mg/rat; the release rate at a dose of 1.35 mg/rat was 2.8% of dose/day; after intramuscular injection the response was similar. In rats, the serum leuprolide acetate levels increased sharply immediately after injection by either route as a consequence of the initial release of the drug; subsequently, the levels attained a plateau for two weeks. The serum level profiles in dogs showed essentially the same pattern as those in rats. When the dosage form was injected into rats, the serum testosterone level (a pharmacological index) sharply peaked, abruptly decreased to below the normal level, and then was sustained at a suppressed level for over six weeks at a dose of 1.35 mg/rat (equivalent to 3 mg kg-1) and higher, while the serum testosterone level after an injection of 0.0135 and 0.135 mg/rat was not sufficiently suppressed. The profiles in dogs showed essentially the same pattern as those in rats. With multiple administrations (once every 4 weeks), serum testosterone levels in dogs did not show any sharp rise after the second and third injections. Changes in rat reproductive organ weights agreed well with the serum testosterone profile in the suppression. The results demonstrate that th…

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Self-citation

Authors: Ogawa, Y., Okada, H., Heya, T., & Shimamoto, T.
Affiliations: Takeda (Japan) (JP)
Corresponding author: Ogawa, Yasuaki
Venue: Journal of Pharmacy and Pharmacology
Publisher: Oxford University Press (OUP)
Published: 1989-07-01
Volume: 41
Issue: 7
Pages: 439-444
ISSN: 0022-3573 (ISSN-L)
2042-7158
DOI: 10.1111/j.2042-7158.1989.tb06497.x
OpenAlex: W2019022309
Cited by: 139
References: 11
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 2
FWCI: 13.36
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Pharmacy and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: leuprolide, GnRH agonist, controlled release, microcapsules, parenteral dosage forms, pharmacokinetics, serum drug concentration, testosterone suppression, gonadotropin-releasing hormone, reproductive organ weight
MeSH terms: Animals, Antineoplastic Agents, Body Weight, Capsules, Chemistry, Pharmaceutical, Delayed-Action Preparations, Dogs, Drug Compounding, Genitalia, Male, Injections, Intramuscular, Injections, Subcutaneous, Gonadotropin-Releasing Hormone, Male, Organ Size, Rats, Inbred Strains, Species Specificity, Testosterone, Time Factors, Leuprolide, Rats

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Controlled Release of LHRH Agonist, Leuprolide Acetate, from Microcapsules: Serum Drug Level Profiles and Pharmacological Effects in Animals

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