CoChat
Sign Up
Cited by 139Advanced Drug Delivery SystemsHypothalamic control of reproductive hormonesHormonal and reproductive studies

The DOI matches its Crossref record, with a small difference in title or year; 11 of the 11 references it cites were found in a registry or an index.

Controlled Release of LHRH Agonist, Leuprolide Acetate, from Microcapsules: Serum Drug Level Profiles and Pharmacological Effects in Animals

Ogawa, Yasuaki, Okada, Hiroaki, Heya, Toshiro, Shimamoto, Tsugio·1989·Journal of Pharmacy and Pharmacology
DOI 10.1111/j.2042-7158.1989.tb06497.x
Open this paper in CoChat — free account

Abstract

The pharmacokinetic behaviour of leuprolide acetate from a controlled release parenteral dosage form has been studied in rats and dogs. The release of the drug in rats after a single subcutaneous injection exhibited pseudo-zero-order kinetics for one month in doses ranging from 0.0135 to 1.35 mg/rat; the release rate at a dose of 1.35 mg/rat was 2.8% of dose/day; after intramuscular injection the response was similar. In rats, the serum leuprolide acetate levels increased sharply immediately after injection by either route as a consequence of the initial release of the drug; subsequently, the levels attained a plateau for two weeks. The serum level profiles in dogs showed essentially the same pattern as those in rats. When the dosage form was injected into rats, the serum testosterone level (a pharmacological index) sharply peaked, abruptly decreased to below the normal level, and then was sustained at a suppressed level for over six weeks at a dose of 1.35 mg/rat (equivalent to 3 mg kg-1) and higher, while the serum testosterone level after an injection of 0.0135 and 0.135 mg/rat was not sufficiently suppressed. The profiles in dogs showed essentially the same pattern as those in rats. With multiple administrations (once every 4 weeks), serum testosterone levels in dogs did not show any sharp rise after the second and third injections. Changes in rat reproductive organ weights agreed well with the serum testosterone profile in the suppression. The results demonstrate that th…

Overview

Integrity signals

Registry

Crossref · 10.1111/j.2042-7158.1989.tb06497.x

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Wise, 1984, Biopolymer system design for sustained release of biological active agents, 3

Cited by

Sorted by citations

See all 139

Related

See all

Metadata

Authors
Ogawa, Y., Okada, H., Heya, T., & Shimamoto, T.
Affiliations
Takeda (Japan) (JP)
Corresponding author
Ogawa, Yasuaki
Venue
Journal of Pharmacy and Pharmacology
Publisher
Oxford University Press (OUP)
Published
1989-07-01
Volume
41
Issue
7
Pages
439-444
ISSN
  • 0022-3573 (ISSN-L)
  • 2042-7158
DOI
10.1111/j.2042-7158.1989.tb06497.x
OpenAlex
W2019022309
Cited by
139
References
11
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 2
FWCI
13.36
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Pharmacy and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
leuprolide, GnRH agonist, controlled release, microcapsules, parenteral dosage forms, pharmacokinetics, serum drug concentration, testosterone suppression, gonadotropin-releasing hormone, reproductive organ weight
MeSH terms
Animals, Antineoplastic Agents, Body Weight, Capsules, Chemistry, Pharmaceutical, Delayed-Action Preparations, Dogs, Drug Compounding, Genitalia, Male, Injections, Intramuscular, Injections, Subcutaneous, Gonadotropin-Releasing Hormone, Male, Organ Size, Rats, Inbred Strains, Species Specificity, Testosterone, Time Factors, Leuprolide, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review