The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pig Ear Skin as an In-vitro Model for Human Skin Permeability
Abstract
Pig skin has been shown to have similar histological and physiological properties to human skin and has been suggested as a good model for human skin permeability. In this series of experiments, the in-vitro permeability of pig ear skin was compared with human (abdominal) skin and rat (dorsal) skin using both hydrophilic (water, mannitol, paraquat) and lipophilic (aldrin, carbaryl, fluazifop-butyl) penetrants. Pig skin was found to have a closer permeability character than rat skin to human skin, particularly for lipophilic penetrants. Electrical conductivity measurements across pig skin membranes showed that skin conductivity could be a useful method for assessing the integrity of membranes, particularly when used in conjunction with water permeability assessments.
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Citations
Cites
Meyer, W., Schwarz, R., & Neurand, K. (2015) · Current Problems in Dermatology · doi:10.1159/000401274 · Cited by 454
Cited by
Schmook, F. P., Meingassner, J. G., & Billich, A. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00665-7 · Cited by 529
Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review
Barbero, A. M., & Frasch, H. F. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.10.008 · Cited by 351
Luo, L., Patel, A., Sinko, B., Bell, M., Wibawa, J., Hadgraft, J., & Lane, M. E. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.03.043 · Cited by 59
Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols
Baccarin, T., & Lemos-Senna, E. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0818-x · Cited by 50
Skin models of cutaneous toxicity, transdermal transport and wound repair
Vilela de Sousa, I., Ferreira, M. J. S., Bebiano, L. B., Simões, S., Matos, A. F., Pereira, R. F., & Granja, P. L. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad014 · Cited by 17
Metadata
- Authors
- Dick, I. P., & Scott, R. C.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-08-01
- Volume
- 44
- Issue
- 8
- Pages
- 640-645
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1969832444
- Cited by
- 362
- References
- 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dick, I. P., & Scott, R. C. (1992). Pig Ear Skin as an In-vitro Model for Human Skin Permeability. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1992.tb05485.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
