Hesperidin-Mediated Expression of Nrf2 and Upregulation of Antioxidant Status in Senescent Rat Heart
Abstract
Objectives: Oxidative stress is recognized as a key element responsible for the development of age-related pathologies. A declining endogenous defence system during senescence dictates the need for supplementation with exogenous antioxidants through diet. Hesperidin is a naturally occurring flavonone present in citrus fruits and has been shown to have many biological properties, including antioxidant activity. We investigated whether hesperidin supplementation could be valuable in protecting cardiac tissue of aged rats against age-related increase in oxidative stress, as well as the mechanism by which it can boost the antioxidant status of the cell. Methods: The activity of antioxidant enzymes, mRNA expression of Nrf2, protein levels of superoxide dismutase and catalase were measured using standard protocols. Key findings: Hesperidin treatment effectively protected aged rat heart by increasing the activity of enzymic antioxidants. Hesperidin upregulated the protein levels of nuclear factor erythroid 2-related factor 2, which is responsible for maintaining the antioxidant status of the cell. Conclusions: Hesperidin could be useful in protecting cardiomyocytes against age-related increase in oxidative stress mediated by Nrf2 upregulation.
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Hesperidin attenuates senescence-related oxidative damage in cardiomyocytes, both independently and in combination with other molecules, through induction of Nrf2 and GST expression.
“Its properties impact positively on cardiomyocytes as it attenuates senescence-related oxidative damage, both independently and in combination with other molecules, through the induction of Nrf2 and of GST expression [247,296,297].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [247]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Elavarasan, J., Velusamy, P., Ganesan, T., Ramakrishnan, S. K., Rajasekaran, D., & Periandavan, K.
- Affiliations
- University of Madras (IN)
- Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai,
- ORCID
- Velusamy, Prema
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10-01
- Volume
- 64
- Issue
- 10
- Pages
- 1472-1482
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1575748956
- Cited by
- 121
- References
- 60
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 13 · 2023: 5 · 2022: 13 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 9 · 2013: 5
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Pharmacy and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
- Keywords
- hesperidin, Nrf2, oxidative stress, cardiac aging, antioxidant status, superoxide dismutase, catalase, flavonoids, cardioprotection
- MeSH terms
- Age Factors, Aging, Animals, Antioxidants, Catalase, Heart, Hesperidin, Male, Myocardium, RNA, Messenger, Superoxide Dismutase, Up-Regulation, Rats, Wistar, Oxidative Stress, NF-E2-Related Factor 2, Rats
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