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Cited by 20Pharmaceutical Practices and Patient OutcomesPatient Safety and Medication ErrorsThyroid Disorders and Treatments

The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.

Management of long-term hypothyroidism: a potential marker of quality of medicines reconciliation in the intensive care unit

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Barrett, Nicholas A, Jones, Andrew, Whiteley, Craig, Yassin, Sarah, McKenzie, Cathrine A·2012·International Journal of Pharmacy Practice
DOI 10.1111/j.2042-7174.2012.00205.x
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Abstract

OBJECTIVE: Significant errors can be made during medication prescribing, dispensing and administration. One source of error and potential for harm is unintentional omission. Medicines reconciliation seeks to reduce the impact of this between transfer of care. In long-term hypothyroidism, patients are dependent upon levothyroxine and there are few contraindications to its prescription. We considered levothyroxine prescription in long-term hypothyroidism as a marker of medicines reconciliation on admission and during stay in the intensive care unit (ICU). METHODS: A retrospective chart review was undertaken in a tertiary referral university ICU with all patients who were receiving long-term levothyroxine therapy identified. Notes were reviewed for the presence of thyroid-replacement prescription and for thyroid function tests, in addition to demographic, length of stay and mortality data. KEY FINDINGS: Thyroid-replacement therapy was not prescribed for more than 7 days in 23/133 (17.3%) patients and omitted entirely in three patients. A further 28/133 (21.1%) patients were intolerant of enteral feeding for more than 7 days and were thus unable to have oral levothyroxine administered. None of these patients received parenteral therapy. Thyroid function tests were performed in 104/133 (78.2%) patients. CONCLUSIONS: Prescription of chronic therapy, in this case thyroid-replacement therapy, was inadequate. This highlights the need for a progressive medicines-reconciliation process embedded within the daily ICU programme.

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Crossref · 10.1111/j.2042-7174.2012.00205.x

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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  • In nine hypothyroid patients who stayed at ICU for 12-45 days and received H2-blockers, after the first 4-8 days at ICU with L-T4 doses unchanged, TSH of all patients increased significantly to 5.69 mU/L (IQR = 3.87-6.83) from 1.52 mU/L (IQR = 0.79-3.8) at admission; L-T4 dose was increased in 8/9 patients (88.9%) from 86.1 ± 41.6 to 125 ± 39.5 μg/d (54.4 ± 31.6%); upon discharge, TSH returned to

    “Nine hypothyroid patients who stayed at ICU for 12–45 days received H2-blockers as routine prophylaxis against gastroduodenal bleeding and were nasogastrically fed a calorically dense solution (96). This solution was stopped 2 h before and resumed 2 h after L-T4 administration (crushed tablets) nasogastrically. After the first 4–8 days at ICU, with L-T4 doses unchanged, TSH of all patients”

    From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [96]

  • The increased L-T4 requirements in ICU patients were attributed to increased gastric pH by H2-blockers (and subsequent decreased L-T4 absorption) and increased T4 to reverse-T3 shunting (due to enhanced type-III deiodinase activity during critical illnesses).

    “The increased L-T4 requirements were attributed to increased gastric pH by H2-blockers (and subsequent decreased L-T4 absorption) and increased T4 to reverse-T3 shunting (due to enhanced type-III deiodinase activity during critical illnesses) (96).”

    From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [96]

  • Among 133 hypothyroid patients hospitalized in intensive care units, thyroid function tests were not performed in 29 (21.8%), replacement therapy was not prescribed for >7 days in 23 (17.3%) and was omitted in three (2.2%).

    “Among 133 such patients, TFTs were not performed in 29 (21.8%), replacement therapy was not prescribed for >7 days in 23 (17.3%) and was omitted in three (2.2%) (95).”

    From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [95]

Citations

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Research works printed but not linked: 1

  1. Corbett, 2010, Improving medicines reconciliation after discharge from a critical care unit, Br J Clin Pharm, 6, 183

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Metadata

Authors
Barrett, N. A., Jones, A., Whiteley, C., Yassin, S., & McKenzie, C. A.
Affiliations
  • St Thomas' Hospital (GB)
  • King's College London (GB)
Corresponding author
McKenzie, Cathrine A
ORCID
Venue
International Journal of Pharmacy Practice
Publisher
Oxford University Press (OUP)
Published
2012-05-02
Volume
20
Issue
5
Pages
303-306
ISSN
  • 0961-7671 (ISSN-L)
  • 2042-7174
DOI
10.1111/j.2042-7174.2012.00205.x
OpenAlex
W1925981434
Cited by
20
References
20
Citations by year
2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 1
FWCI
0.79
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Pharmacy Practice (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Patient Safety and Medication Errors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords
levothyroxine, medication reconciliation, intensive care unit, medication omission, thyroid function tests, enteral feeding intolerance, medication errors, quality of care
MeSH terms
Administration, Oral, Aged, Enteral Nutrition, Female, Hospitals, University, Humans, Hypothyroidism, Intensive Care Units, Length of Stay, Male, Medication Errors, Patient Admission, Retrospective Studies, Thyroid Function Tests, Thyroxine, Time Factors, Medication Reconciliation

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