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Cited by 25Chemotherapy-related skin toxicityOral health in cancer treatmentEffects of Radiation Exposure

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Gel of chamomile vs. urea cream to prevent acute radiation dermatitis in patients with head and neck cancer: a randomized controlled trial

Ferreira, Elaine Barros, Ciol, Marcia A., Vasques, Christiane Inocêncio, Bontempo, Priscila de Souza Maggi, Vieira, Nayara Narley Pires, Silva, Luis Felipe Oliveira e, Avelino, Samuel Ramalho, dos Santos, Marcos Antônio, dos Reis, Paula Elaine Diniz·2016·Journal of Advanced Nursing
DOI 10.1111/jan.12955
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Abstract

Aim: To compare a gel made with chamomile (Chamomilla recutita) with a cream of urea as an intervention to delay the time to occurrence of radiation dermatitis. Background: Radiation dermatitis is one of the most common adverse effects of radiotherapy in patients with head and neck cancer. It is characterized by erythema, itching, pain, skin breakage and burning sensation, and there is no consensus on how to prevent it. Design: The study is a randomized controlled clinical trial. Methods: We will recruit 48 individuals with head and neck cancer who will be starting their radiotherapy and randomize them to receive either gel of chamomile or cream of urea, as an intervention for prevention of radiation dermatitis. Social‐demographic data will be collected at baseline, and clinical data will be collected before the initiation of radiotherapy. Participants will be followed weekly to assess development of radiation dermatitis. The protocol is funded by Conselho Nacional de Pesquisa e Desenvolvimento Científico (Brazil). The study was approved by a research ethics committee. Discussion: Given the clinical relevance of preventing radiation dermatitis and the lack of evidence supporting specific preventive interventions, it is important to study new products that might be efficacious to prevent this complication. This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy.

Overview

Integrity signals

Registry

Crossref · 10.1111/jan.12955

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • Ferreira et al. review on Chamomilla Recutita's topical effects lacks critical analysis, evidence synthesis, and adherence to the Oxford evidence hierarchy.

    “In summary, the study offers a helpful summary of Chamomilla Recutita's possible advantages for treating skin damage, but it falls short in terms of critical analysis, evidence synthesis, and adherence to the Oxford evidence hierarchy.”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [8]

Citations

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Research works printed but not linked: 2

  1. Sobin L.H., 2009, UICC TNM Classification of Malignant Tumours
  2. US Department of Health and Human Services, National Institutes of Health and National Cancer Institute, 2010, Common Terminology Criteria for Adverse Events (CTCAE). v4.03

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Metadata

Authors
Ferreira, E. B., Ciol, M. A., Vasques, C. I., Bontempo, P. D. S. M., Vieira, N. N. P., Silva, L. F. O. E., Avelino, S. R., dos Santos, M. A., & dos Reis, P. E. D.
Affiliations
  • Universidade de Brasília (BR)
  • University of Washington (US)
  • Hospital Universitário de Brasília (BR)
  • University Hospital of Brasília Brazil
  • University of Brasília Brazil
ORCID
Venue
Journal of Advanced Nursing
Publisher
Wiley
Published
2016-03-29
Volume
72
Issue
8
Pages
1926-1934
ISSN
  • 0309-2402 (ISSN-L)
  • 1365-2648
DOI
10.1111/jan.12955
OpenAlex
W2334101802
Cited by
25
References
26
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 3 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 1
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Advanced Nursing (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Committee for Research and Scientific Development
Topics
  • Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
  • Health Sciences › Dentistry › General Dentistry › Oral health in cancer treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
radiation dermatitis, head and neck cancer, chamomile, Chamomilla recutita, urea cream, topical gel, radiotherapy complications, radiation dermatitis prevention, erythema
MeSH terms
Administration, Topical, Brazil, Head and Neck Neoplasms, Humans, Radiodermatitis, Research Design, Urea, Chamomile

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