Plasma parathyroid hormone and cardiovascular disease in treatment‐naive patients with primary hyperparathyroidism: The EPATH trial
Open accessAbstract
Patients with primary hyperparathyroidism are at increased risk for high blood pressure, vascular stiffening, and left ventricular hypertrophy, but previous studies have failed to demonstrate the direct associations with circulating parathyroid hormone (PTH) levels. The authors investigated cross‐sectional relationships between PTH and 24‐hour pulse wave velocity, nocturnal systolic blood pressure, and left ventricular mass index in patients with primary hyperparathyroidism who were treatment‐naive with cinacalcet, renin‐angiotensin‐aldosterone‐system inhibitors, and thiazide or loop diuretics. In 76 patients, mean±SD of pulse wave velocity, nocturnal systolic blood pressure, and left ventricular mass index values were 9.3±1.8 m/s, 116.6±17.0 mm Hg, and 92.8±23.0 g/m². In multivariate linear regression analyses with adjustment for potentially confounding parameters, PTH was independently associated with nocturnal systolic blood pressure (adjusted ß coefficient=.284, P=.040), mean 24‐hour pulse wave velocity (ß=.199, P=.001), and left ventricular mass index (ß=.252, P=.025). PTH may promote vascular and cardiac remodeling in primary hyperparathyroidism. Interventional trials are needed to test the antihypertensive and cardioprotective effects of PTH‐inhibitory treatment strategies.
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- Authors
- Wetzel, J., Pilz, S., Grübler, M. R., Fahrleitner‐Pammer, A., Dimai, H. P., von Lewinski, D., Kolesnik, E., Perl, S., Trummer, C., Schwetz, V., Meinitzer, A., Belyavskiy, E., Völkl, J., Catena, C., Brandenburg, V., März, W., Pieske, B., Brussee, H., Tomaschitz, A., & Verheyen, N. D.
- Affiliations
- Universitätsklinikum Aachen (DE)
- Medical University of Graz (AT)
- University Hospital of Bern (CH)
- Department of Cardiology Medical University Graz Graz Austria
- University of Graz (AT)
- Department of Internal Medicine Division of Endocrinology and Diabetology Medical University of Graz Graz Austria
- Charité – Universitätsmedizin Berlin (DE)
- Department of Cardiology Campus Virchow Charité University Berlin Germany
- University of Udine (IT)
- Heidelberg University (DE)
- Corresponding author
- Wetzel, Julia
- Verheyen, Nicolas D.
- ORCID
- Venue
- The Journal of Clinical Hypertension
- Publisher
- Wiley
- Published
- 2017-08-20
- Volume
- 19
- Issue
- 11
- Pages
- 1173-1180
- ISSN
- 1524-6175 (ISSN-L)
- 1751-7176
- PMC
- PMC8030827
- OpenAlex
- W2745676945
- Cited by
- 22
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 9 · 2019: 1 · 2017: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Oesterreichische Nationalbank (14621)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- primary hyperparathyroidism, parathyroid hormone, cardiovascular disease, pulse wave velocity, left ventricular mass, vascular stiffness, left ventricular hypertrophy, vascular remodeling, cardiac remodeling, treatment-naive patients, cinacalcet, renin-angiotensin-aldosterone system inhibitors
- MeSH terms
- Aged, Antihypertensive Agents, Blood Pressure, Cardiotonic Agents, Cardiovascular Diseases, Echocardiography, Female, Heart Ventricles, Humans, Hypertension, Male, Middle Aged, Organ Size, Parathyroid Hormone, Blood Pressure Monitoring, Ambulatory, Hyperparathyroidism, Primary, Pulse Wave Analysis
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