Peroxiredoxin 1 – an antioxidant enzyme in cancer

Structure, mechanism and regulation of peroxiredoxins

Wood, Z. A., Schröder, E., Harris, J. R., & Poole, L. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00003-8 · Cited by 2,546 · see citing works

Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

Rhee, S. G., Chae, H. Z., & Kim, K. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.026 · Cited by 1,409 · see citing works

Regulation of JNK signaling by GSTp

Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1321 · Cited by 1,105 · see citing works

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., & Van Etten, R. A. (2003) · Nature · doi:10.1038/nature01819 · Cited by 801 · see citing works

Two Enzymes in One

Jang, H. H., Lee, K. O., Chi, Y. H., Jung, B. G., Park, S. K., Park, J., Lee, J. R., Lee, S. S., Moon, J. C., Yun, J. W., et al. (2004) · Cell · doi:10.1016/j.cell.2004.05.002 · Cited by 768 · see citing works

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

Gupta, S. C., Hevia, D., Patchva, S., Park, B., Koh, W., & Aggarwal, B. B. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4414 · Cited by 736 · see citing works

Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

Niculescu, A. B., Chen, X., Smeets, M. F. M. A., Hengst, L., Prives, C. L., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.629 · Cited by 725 · see citing works

Peroxiredoxin, a Novel Family of Peroxidases

Rhee, S. G., Kang, S. W., Chang, T., Jeong, W., & Kim, K. (2001) · IUBMB Life · doi:10.1080/15216540252774748 · Cited by 642 · see citing works

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H ₂ O ₂ , and Protein Chaperones

Rhee, S. G., & Woo, H. A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3393 · Cited by 463 · see citing works

Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth

Giannoni, E., Buricchi, F., Raugei, G., Ramponi, G., & Chiarugi, P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6391-6403.2005 · Cited by 455 · see citing works

Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein

Fujii, J., & Ikeda, Y. (2002) · Redox Report · doi:10.1179/135100002125000352 · Cited by 369 · see citing works

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

Cao, J., Schulte, J., Knight, A., Leslie, N. R., Zagożdżon, A., Bronson, R. T., Manevich, Y., Beeson, C. C., & Neumann, C. A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.101 · Cited by 344 · see citing works

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

Parmigiani, R. B., Xu, W., Venta-Perez, G., Erdjument‐Bromage, H., Yaneva, M., Tempst, P., & Marks, P. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803749105 · Cited by 325 · see citing works

Glutathione S-transferase P1–1 (GSTP1–1) Inhibits c-Jun N-terminal Kinase (JNK1) Signaling through Interaction with the C Terminus

Wang, T., Arifoglu, P., Ronai, Z. A., & Tew, K. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101355200 · Cited by 313 · see citing works

Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death

Moon, J. C., Hah, Y., Kim, W. Y., Jung, B. G., Jang, H. H., Lee, J. R., Kim, S. Y., Lee, Y., Jeon, M. G., Kim, C. W., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505362200 · Cited by 300 · see citing works

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I., & Suda, T. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22764 · Cited by 290 · see citing works

Peroxiredoxin 1 and its role in cell signaling

Neumann, C. A., Cao, J., & Manevich, Y. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10242 · Cited by 268 · see citing works

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activityPreprint

Wen, S.-T., & Etten, R. A. V. (1997) · Genes & Development · doi:10.1101/gad.11.19.2456 · Cited by 267 · see citing works

Glutathione S-Transferase p Elicits Protection against H2O2-induced Cell Death via Coordinated Regulation of Stress Kinases

Yin, Z., Ivanov, V. N., Habelhah, H., Tew, K. D., & Ronai, Z. A. (2000) · PubMed · doi:10.7916/d8571b9j · Cited by 264 · see citing works

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product

Hirotsu, S., Abe, Y., Okada, K., Nagahara, N., Hori, H., Nishino, T., & Hakoshima, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12333 · Cited by 252 · see citing works

The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction

Netto, L. E. S., & Antunes, F. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2349 · Cited by 237 · see citing works

Angiogenesis and prostate cancer: identification of a molecular progression switch.

Huss, W. J., Hanrahan, C. F., Barrios, R. J., Simons, J. W., & Greenberg, N. M. (2001) · PubMed · Cited by 234 · see citing works

Peroxiredoxins in breast carcinoma.

Karihtala, P., Mäntyniemi, A., Kang, S. W., Kinnula, V. L., & Soini, Y. (2003) · PubMed · Cited by 232 · see citing works

Regulation of reactive oxygen species, DNA damage and c-Myc function by peroxiredoxin 1

Egler, R. A., Fernandes, E. R., Rothermund, K. D., Sereika, S. M., de Souza-Pinto, N. C., Jaruga, P., Dizdaroğlu, M., & Prochownik, E. V. (2005) · Oncogene · doi:10.1038/sj.onc.1208821 · Cited by 231 · see citing works

Overexpression of peroxiredoxin in human breast cancer.

Noh, D.-Y., Ahn, S. J., Lee, R., Kim, S., Park, I. A., & Chae, H. Z. (2001) · PubMed · Cited by 221 · see citing works

Erratum: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (Molecular and Cellular Biology 18:1 (629))

Niculescu, A. B., Chen, X., Smeets, M. F. M. A., Hengst, L., Prives, C. L., & Reed, S. I. (1998) · Molecular and Cellular Biology · Cited by 177 · see citing works

Peroxiredoxins, a novel protein family in lung cancer

Lehtonen, S. T., Svensk, A., Soini, Y., Pääkkö, P. K., Hirvikoski, P. P., Kang, S. W., Säily, M., & Kinnula, V. L. (2004) · International Journal of Cancer · doi:10.1002/ijc.20294 · Cited by 170 · see citing works

Novel roles of peroxiredoxins in inflammation, cancer and innate immunity

Ishii, T., Warabi, E., & Yanagawa, T. (2012) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-109 · Cited by 160 · see citing works

The role of tumor suppressor p53 in the antioxidant defense and metabolism

Budanov, A. V. (2014) · Subcellular Biochemistry · doi:10.1007/978-94-017-9211-0_18 · Cited by 157 · see citing works

Human Peroxiredoxin 1 and 2 Are Not Duplicate Proteins

Lee, W., Choi, K., Riddell, J. R., Ip, C. C. Y., Ghosh, D., Park, J.-H., & Park, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610330200 · Cited by 157 · see citing works

Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex

Kim, Y.-J., Lee, W.-S., Ip, C. C. Y., Chae, H., Park, E., & Park, Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4446 · Cited by 152 · see citing works

NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas

Leone, P., Bello, M. J., de Campos, J. M., Vaquero, J., Sarasa, J. L., Pestaña, Á., & REY, J. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202531 · Cited by 146 · see citing works

Using Proteomic Approach to Identify Tumor-Associated Proteins as Biomarkers in Human Esophageal Squamous Cell Carcinoma

Zhang, J., Wang, K., 张建中, Liu, S. S., Dai, L., & Zhang, J.-Y. (2011) · Journal of Proteome Research · doi:10.1021/pr200141c · Cited by 144 · see citing works

Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

Cha, M., Suh, K.-H., & Kim, I.-H. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-93 · Cited by 143 · see citing works

Augmented Expression of Peroxiredoxin I in Lung Cancer

Chang, J. W., Jeon, H. B., Lee, J. H., Yoo, J. S., Chun, J. S., Kim, J., & Yoo, Y. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5989 · Cited by 139 · see citing works

Identification of a Natural Killer Enhancing Factor (NKEF) from Human Erythroid Cells

Shau, H., Gupta, R. K., & Golub, S. H. (1993) · Cellular Immunology · doi:10.1006/cimm.1993.1043 · Cited by 138 · see citing works

Pag, a Putative Tumor Suppressor, Interacts with the Myc Box II Domain of c-Myc and Selectively Alters Its Biological Function and Target Gene Expression

Mu, Z. M., Yin, X. Y., & Prochownik, E. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206066200 · Cited by 137 · see citing works

Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach

Li, R., Wang, H., Bekele, B. N., Yin, Z., Caraway, N. P., Katz, R. L., Stass, S. A., & Jiang, F. (2005) · Oncogene · doi:10.1038/sj.onc.1209289 · Cited by 131 · see citing works

Are peroxiredoxins tumor suppressors?

Neumann, C. A., & Fang, Q. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.04.007 · Cited by 129 · see citing works

Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation

Iwabuchi, T., Yoshimoto, C., Shigetomi, H., & Kobayashi, H. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/848595 · Cited by 128 · see citing works

A novel function of peroxiredoxin 1 (Prx‐1) in apoptosis signal‐regulating kinase 1 (ASK1)‐mediated signaling pathway

Kim, S. Y., Kim, T. J., & Lee, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.05.015 · Cited by 127 · see citing works

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

Xiao, L., Chen, D., Hu, P., Wu, J., Liu, W., Zhao, Y. L., Cao, M., Fang, Y., Bi, W., Zheng, Z., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0035-11.2011 · Cited by 123 · see citing works

Peroxiredoxins, a novel target in cancer radiotherapy

Zhang, B., Wang, Y., & Su, Y. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.043 · Cited by 122 · see citing works

Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4–Dependent Regulation of Tumor Vasculature

Riddell, J. R., Bshara, W., Moser, M. T., Spernyak, J. A., Foster, B. A., & Gollnick, S. O. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3674 · Cited by 121 · see citing works

Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues

Kim, H. J., Chae, H. Z., KIM, Y., Kim, Y. H., Hwang, T. S., Park, E.-M., & Park, Y.-M. (2003) · Cell Biology and Toxicology · doi:10.1023/b:cbto.0000004952.07979.3d · Cited by 108 · see citing works

Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung

Park, J. H., Kim, Y. S., Lee, H. L., et al. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00849.x · Cited by 103 · see citing works

Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity

Hua, D., Liu, M.-Y., Cheng, Z.-D., Qin, X.-J., Zhang, H.-M., Chen, Y., Qin, G.-J., Liang, G., Li, J., Han, X.-F., et al. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.06.016 · Cited by 102 · see citing works

Up-Regulation of Peroxiredoxin 1 in Lung Cancer and Its Implication as a Prognostic and Therapeutic Target

Kim, J.-H., Bogner, P. N., Baek, S.-H., Ramnath, N., Liang, P., Kim, H.-R., Andrews, C., & Park, Y. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4457 · Cited by 97 · see citing works

Deletion of chromosome 1p and loss of expression of alkaline phosphatase indicate progression of meningiomas.

Müller, P., Henn, W., Niedermayer, I., et al. (1999) · PubMed · Cited by 93 · see citing works

Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-κB activities

Hansen, J. M., Moriarty-Craige, S. E., & Jones, D. P. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.029 · Cited by 92 · see citing works

Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression

Chen, M., Keng, P. C., Shau, H., Wu, C., Hu, Y., Liao, S., & Chen, W. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.10.012 · Cited by 91 · see citing works

Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

Morinaka, A., Funato, Y., Uesugi, K., & Miki, H. (2011) · Oncogene · doi:10.1038/onc.2011.139 · Cited by 89 · see citing works

Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer

Turner-Ivey, B., Manevich, Y., Schulte, J. H., Kistner‐Griffin, E., Jezierska‐Drutel, A., Liu, Y., & Neumann, C. A. (2013) · Oncogene · doi:10.1038/onc.2012.624 · Cited by 88 · see citing works

Identification of Peroxiredoxin-1 as a Novel Biomarker of Abdominal Aortic Aneurysm

Martínez-Pinna, R., Ramos‐Mozo, P., Madrigal‐Matute, J., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.214429 · Cited by 88 · see citing works

Differential expression of peroxiredoxins in prostate cancer: Consistent upregulation of PRDX3 and PRDX4

Basu, A., Banerjee, H., Rojas, H., et al. (2010) · The Prostate · doi:10.1002/pros.21292 · Cited by 87 · see citing works

Peroxiredoxin‐I is an autoimmunogenic tumor antigen in non‐small cell lung cancer

Chang, J. W., Lee, S. H., Jeong, J. Y., Chae, H. Z., Kim, Y. C., Park, Z., & Yoo, Y. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.028 · Cited by 85 · see citing works

Peroxiredoxin 1 Interacts with Androgen Receptor and Enhances Its Transactivation

Park, S., Yu, X., Ip, C. C. Y., Mohler, J. L., Bogner, P. N., & Park, Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0651 · Cited by 81 · see citing works

Elevated Peroxiredoxin 1, but not NF-E2–Related Factor 2, Is an Independent Prognostic Factor for Disease Recurrence and Reduced Survival in Stage I Non–Small Cell Lung Cancer

Kim, J.-H., Bogner, P. N., Ramnath, N., Park, Y., Yu, J., & Park, Y. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2893 · Cited by 80 · see citing works

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

O’Leary, P. C., Terrile, M., Bajor, M., Gaj, P., Hennessy, B. T., Mills, G. B., Zagożdżon, A., O’Connor, D. P., Brennan, D. J., Connor, K., et al. (2014) · Breast Cancer Research · doi:10.1186/bcr3691 · Cited by 80 · see citing works

Peroxiredoxin 1 Stimulates Endothelial Cell Expression of VEGF via TLR4 Dependent Activation of HIF-1α

Riddell, J. R., Maier, P. G., Sass, S. N., Moser, M. T., Foster, B. A., & Gollnick, S. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050394 · Cited by 78 · see citing works

Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high‐mobility group protein B1

Shiota, M., Izumi, H., Miyamoto, N., et al. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00912.x · Cited by 69 · see citing works

Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions

Lee, D. J., Kang, D. H., Choi, M., Choi, Y. J., Lee, J. Y., Park, J. H., Park, Y. J., Lee, K. W., & Kang, S. W. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4226 · Cited by 69 · see citing works

The Nitric Oxide Prodrug JS-K Is Effective against Non–Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen Species

Maciag, A. E., Chakrapani, H., Saavedra, J. E., Morris, N. L., Holland, R. J., Kosak, K. M., Shami, P. J., Anderson, L. M., & Keefer, L. K. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.174904 · Cited by 68 · see citing works

Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc

Gertz, M., Fischer, F. F., Leipelt, M., Wolters, D. A., & Steegborn, C. (2009) · Aging · doi:10.18632/aging.100017 · Cited by 64 · see citing works

Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism

Bonilla-Porras, A. R., Jiménez-Del-Río, M., & Velez‐Pardo, C. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-19 · Cited by 64 · see citing works

MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer

Guo, Q. J., Mills, J. N., Bandurraga, S. G., et al. (2013) · Breast Cancer Research · doi:10.1186/bcr3464 · Cited by 63 · see citing works

Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C

Li, J., Xiang, S., Zhang, Q., Wu, J., Tang, Q., Zhou, J., Yang, L., Chen, Z., & Hann, S. S. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0168-z · Cited by 62 · see citing works

Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest

Li, G., Zhang, Z., Wang, R., Ma, W., Yang, Y., Wei, J., & Wei, Y. (2013) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-32-20 · Cited by 61 · see citing works

Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis

Choe (2009) · Oncology Reports · doi:10.3892/or_00000366 · Cited by 61 · see citing works

Integrated analysis of genome‐wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype‐negative colon cancer

Loo, L. W. M., Tiirikainen, M., Cheng, I. C., Lum‐Jones, A., Seifried, A., Church, J. M., Gryfe, R., Weisenberger, D. J., Lindor, N. M., Gallinger, S., et al. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22043 · Cited by 60 · see citing works

MicroRNA-Mediated Inhibition of Prostate-Derived Ets Factor Messenger RNA Translation Affects Prostate-Derived Ets Factor Regulatory Networks in Human Breast Cancer

Findlay, V. J., Turner, D. P., Moussa, O., & Watson, D. K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0907 · Cited by 60 · see citing works

Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy.

Jiang, H., Wu, L., Mishra, M., Chawsheen, H. A., & Wei, Q. (2014) · Europe PMC (PubMed Central) · Cited by 58 · see citing works

Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer

Cai, C.-Y., Zhai, L., Wu, Y., & Tang, Z. (2014) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2014.11.037 · Cited by 56 · see citing works

Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor Prdx1 with Apoptosis Induction in Esophageal Cancer Cells

Hoshino, I., Matsubara, H., Hanari, N., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0840 · Cited by 56 · see citing works

C-Abl as a modulator of p53

Levav-Cohen, Y., Goldberg, Z., Zuckerman, V., Grossman, T., Haupt, S., & Haupt, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.152 · Cited by 55 · see citing works

Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

Zhiyu, W., Cheng, Y., Wang, N., Mei, W. D., Li, W., Feng, H., Gang, S. J., Po, Y. D., Yuan, G. X., & Chen, J. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.13.3.18693 · Cited by 54 · see citing works

Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity

Taniuchi, K., Furihata, M., Hanazaki, K., et al. (2014) · Pancreas · doi:10.1097/mpa.0000000000000270 · Cited by 54 · see citing works

Prx I Suppresses K-ras-Driven Lung Tumorigenesis by Opposing Redox-Sensitive ERK/Cyclin D1 Pathway

Park, Y., Kim, S., Lee, B.-K., Kim, H.-S., Song, I.-S., Shin, H.-J., Han, Y., Chang, K.-T., Kim, J., Lee, D., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4421 · Cited by 53 · see citing works

Genome wide expression profiling identifies genes associated with colorectal liver metastasis

Lin, H., Chatterjee, A., Lin, Y., et al. (2007) · Oncology Reports · doi:10.3892/or.17.6.1541 · Cited by 52 · see citing works

Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma

Ren, P., Ye, H., Dai, L., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2714 · Cited by 52 · see citing works

Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34

Sulman, E. P., White, P. S., & Brodeur, G. M. (2004) · Oncogene · doi:10.1038/sj.onc.1206623 · Cited by 51 · see citing works

Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer

Woolston, C. M., Storr, S. J., Ellis, I. O., Morgan, D. A. L., & Martin, S. G. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.05.029 · Cited by 49 · see citing works

Genetic Analysis of Androgen Receptors in Development and Disease

Brinkmann, A. O., & Trapman, J. (1999) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60115-5 · Cited by 48 · see citing works

Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation

Kalinina, E. V., Berezov, T. T., Shtil, A. A., Чернов, Н. Н., Glazunova, V. A., Novichkova, M., & Какамурадович, Н. Н. (2012) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-012-1849-7 · Cited by 48 · see citing works

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma

Trzeciecka, A., Kłossowski, S., Bajor, M., Zagożdżon, R., Gaj, P., Muchowicz, A., Malinowska, A., Czerwoniec, A., Barankiewicz, J., Domagała, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6435 · Cited by 47 · see citing works

Allelic Losses in Neurofibromatosis 2-Associated Meningiomas

Lamszus, K., Vahldiek, F., Mautner, V., et al. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.6.504 · Cited by 47 · see citing works

Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo

Anandasadagopan, S. K., Mohebali, N., Looi, C. Y., Hasanpourghadi, M., Pandurangan, A. K., Arya, A., Karimian, H., & Mustafa, M. R. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0266-y · Cited by 44 · see citing works

Prx1 Enhances Androgen Receptor Function in Prostate Cancer Cells by Increasing Receptor Affinity to Dihydrotestosterone

Chhipa, R. R., Lee, K.-S., Oñate, S. A., Wu, Y., & Ip, C. C. Y. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0546 · Cited by 43 · see citing works

Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma

Gong, F., Hou, G., Liu, H., et al. (2015) · Medical Oncology · doi:10.1007/s12032-014-0455-0 · Cited by 42 · see citing works

Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity

McDonald, C., Muhlbauer, J., Perlmutter, G., Taparra, K., & Phelan, S. A. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2398 · Cited by 42 · see citing works

Human peroxiredoxin 1 modulates TGF-β1-induced epithelial–mesenchymal transition through its peroxidase activity

Ha, B., Kim, E.-K., Kim, J., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.103 · Cited by 41 · see citing works

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro

Dittmann, L. M., Danner, A., Gronych, J., et al. (2011) · Oncogene · doi:10.1038/onc.2011.513 · Cited by 41 · see citing works

Selective Association of Peroxiredoxin 1 with Genomic DNA and COX-2 Upstream Promoter Elements in Estrogen Receptor Negative Breast Cancer Cells

Wang, X., He, S., Sun, J., Delcuve, G. P., & Davie, J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-02-0160 · Cited by 40 · see citing works

Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure

Rostila, A., Puustinen, A., Toljamo, T., et al. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.03.024 · Cited by 39 · see citing works

PRDX1 and PRDX6 are repressed in papillary thyroid carcinomas via BRAF V600E-dependent and -independent mechanisms

Nicolussi, A., D'inzeo, S., Mincione, G., Buffone, A., Marcantonio, M. C. D., Cotellese, R., Cichella, A., Capalbo, C., Gioia, C. R. T. D., NARDI, F., et al. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2208 · Cited by 39 · see citing works

The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells

Schultz, M., Abdel‐Mageed, A. B., & Mondal, D. (2010) · Cancers · doi:10.3390/cancers2021354 · Cited by 37 · see citing works

Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer

Sun, Y. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i38.10840 · Cited by 36 · see citing works

Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation

Gao, M., Jia, X., Wu, Q., et al. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.235 · Cited by 35 · see citing works

Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin–binding phosphoprotein 50 in cholangiocarcinoma

Yonglitthipagon, P., Pairojkul, C., Chamgramol, Y., et al. (2012) · Human Pathology · doi:10.1016/j.humpath.2011.11.021 · Cited by 35 · see citing works

Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration

Suresh, S., Raghu, D., & Karunagaran, D. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.9.5461 · Cited by 35 · see citing works

Analysis of Gene Expression Profiles of Soft Tissue Sarcoma Using a Combination of Knowledge-Based Filtering with Integration of Multiple Statistics

Takahashi, A., Nakayama, R. T., Ishibashi, N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106801 · Cited by 33 · see citing works

Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients

Hoshino, I., Matsubara, H., Akutsu, Y., et al. (2007) · Oncology Reports · doi:10.3892/or.18.4.867 · Cited by 33 · see citing works

Quantitative tissue proteomic investigation of invasive ductal carcinoma of breast with luminal B HER2 positive and HER2 enriched subtypes towards potential diagnostic and therapeutic biomarkers

Pendharkar, N., Gajbhiye, A., Taunk, K., RoyChoudhury, S., Dhali, S., Seal, S., Mane, A. D., Abhang, S. A., Santra, M. K., Chaudhury, K., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.11.024 · Cited by 32 · see citing works

PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug

He, T., Hatem, E., Vernis, L., Lei, M., & Huang, M. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0270-2 · Cited by 32 · see citing works

Downregulation of peroxiredoxin-1 by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts

Li, G., Xie, B.-B., Li, X., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.3732 · Cited by 31 · see citing works

Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress

Poschmann, G., Grzendowski, M., Stefanski, A., Bruns, E., Meyer, H. E., & Stühler, K. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.11.011 · Cited by 29 · see citing works

Inhibitory Effect of Vitamin C in Combination With Vitamin K3 on Tumor Growth and Metastasis of Lewis Lung Carcinoma Xenografted in C57BL/6 Mice

Chen, M.-F., Yang, C., Su, C.-M., et al. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.597537 · Cited by 28 · see citing works

The antiandrogenic effect of finasteride against a mutant androgen receptor

Wu, Y., Chhipa, R. R., Zhang, H., & Ip, C. C. Y. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.10.15187 · Cited by 28 · see citing works

Expression of Peroxiredoxin and Thioredoxin in Human Lung Cancer and Paired Normal Lung

Kim, Y. S., Park, J. H., Lee, H. L., et al. (2005) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2005.59.2.142 · Cited by 28 · see citing works

ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder

Li, J., Yang, Z., Ren, X., et al. (2012) · Tumor Biology · doi:10.1007/s13277-012-0557-2 · Cited by 27 · see citing works

Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits

Yen, C., Liang, S.-C., Jong, Y.-J., Chen, Y.-J., Lin, C.-H., Chen, Y.-M., Wu, Y., Su, W., Huang, C. F., Tseng, S.-W., et al. (2007) · Lung Cancer · doi:10.1016/j.lungcan.2007.04.007 · Cited by 27 · see citing works

ADAM28: A potential oncogene involved in asbestos‐related lung adenocarcinomas

Wright, C. M., Larsen, J. E., Hayward, N. K., et al. (2010) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20779 · Cited by 27 · see citing works

Proteomic Analysis of Bladder Cancer Indicates Prx-I as a Key Molecule in BI-TK/GCV Treatment System

Li, J., Xiao, X., Ren, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098764 · Cited by 26 · see citing works

Proteomic analysis of non-small cell lung cancer tissue interstitial fluids

Li, S., Wang, R., Zhang, M., et al. (2013) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-11-173 · Cited by 25 · see citing works

Differential Expression and Function of Peroxiredoxin 1 and Peroxiredoxin 6 in Cancerous MCF-7 and Noncancerous MCF-10A Breast Epithelial Cells

Goncalves, K., Sullivan, K. L., & Phelan, S. A. (2012) · Cancer Investigation · doi:10.3109/07357907.2011.629382 · Cited by 25 · see citing works

Proteomics analysis of stage-specific proteins expressed in human squamous cell lung carcinoma tissues

Deng, B., Ye, N., Luo, G., et al. (2005) · Cancer Biomarkers · doi:10.3233/cbm-2005-1603 · Cited by 22 · see citing works

CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction

Yang, C.-R., Liao, W., Wu, Y.-H., Murugan, K., Chen, C., & Chao, J. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.007 · Cited by 22 · see citing works

p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment

Chen, M., Chen, W., Wu, C., et al. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2006.07.1372 · Cited by 22 · see citing works

Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells

Du, Z., Yan, Y., Zhang, H., Liu, B.-Q., Gao, Y., Niu, X., Guan, Y., Meng, X., & Wang, H. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0269 · Cited by 22 · see citing works

Dysregulation of redox‐state‐regulating enzymes in melanocytic skin tumours and the surrounding microenvironment

Teppo, H., Soini, Y., Haapasaari, K., et al. (2015) · Histopathology · doi:10.1111/his.12659 · Cited by 20 · see citing works

Prx1 modulates the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis

Hwang, K., Park, D., Kim, Y. S., Kim, B.-R., Park, S. N., Lee, M., Park, S., Yoon, K., Jeong, E., & Kim, H.-R. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1918 · Cited by 17 · see citing works

In vitro the behaviors of metastasis with suppression of VEGF in human bone metastatic LNCaP-derivative C4-2B prostate cancer cell line

Yang, L. F., You, S., Kumar, V., Zhang, C., & Cao, Y. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-40 · Cited by 17 · see citing works

Focus on 16p13.3 Locus in Colon Cancer

Mampaey, E., Fieuw, A., Laethem, T. V., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131421 · Cited by 16 · see citing works

Peroxiredoxin 1 is involved in disassembly of flagella and cilia

Gong, F., Liu, H., Li, J., Xue, L., & Zhang, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.081 · Cited by 15 · see citing works

Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas

Demasi, A., Magalhães, M. H. C. G. D., Furuse, C., de Araújo, N., Junqueira, J. L. C., & de Araújo, V. C. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2008.01455.x · Cited by 15 · see citing works

Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells

Guo, Q., Huang, X., Zhang, J., Luo, Y., Peng, Z., & Li, S. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2011.0989 · Cited by 14 · see citing works

Effects of Vitamin K3 and K5 on Daunorubicin-resistant Human T Lymphoblastoid Leukemia Cells.

Nakaoka, E., Tanaka, S., Onda, K., et al. (2015) · PubMed · Cited by 14 · see citing works

Elevated Prx1 Provides Resistance to Docetaxel, But Is Not Associated with Predictive Significance in Lung Cancer

Hwang, K., Park, C., Seol, C. H., et al. (2013) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2013.75.2.59 · Cited by 12 · see citing works

Overexpression of Prdx1 in hilar cholangiocarcinoma: a predictor for recurrence and prognosis.

Zhou, J., Shen, W., He, X., et al. (2015) · PubMed · Cited by 12 · see citing works

Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs – an alternative approach for chemotherapy

He, T., Hatem, E., Vernis, L., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.583 · Cited by 7 · see citing works

Total peroxiredoxin expression is associated with survival in patients with follicular lymphoma

Peroja, P., Haapasaari, K., Mannisto, S., et al. (2016) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-016-1920-2 · Cited by 7 · see citing works

Sunlight damage to cellular DNA: focus on oxidatively generated lesions

Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Kraljević Pavelić, S., Simović Medica, J., Gumbarević, D., Filošević, A., Pržulj, N., & Pavelić, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01350 · Cited by 247 · see citing works

Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

Rayaprolu, S., Higginbotham, L., Bagchi, P., Watson, C. M., Zhang, T., Levey, A. I., Rangaraju, S., & Seyfried, N. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00840-3 · Cited by 118 · see citing works

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E., & Bliska, J. B. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31021-3

Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens

Liu, T., Chen, Y., Tian, S., et al. (2023) · Horticulturae · doi:10.3390/horticulturae9020250 · Cited by 9 · see citing works

Prediction of effector proteins and their implications in pathogenicity of phytopathogenic filamentous fungi: A review

Wu, Y., Xie, L., Jiang, Y., & Li, T. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.133 · Cited by 35 · see citing works

Microbial Pathogen Effectors in Plant Disease

Pelgrom, A. J. E., & den Ackerveken, G. F. J. M. V. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023724 · Cited by 7 · see citing works

Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi

Jones, D., Moolhuijzen, P., & Hane, J. K. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000637 · Cited by 13 · see citing works