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Cited by 264Oral microbiology and periodontitis researchDental Health and Care UtilizationPeriodontal Regeneration and Treatments

Natural history of periodontitis: Disease progression and tooth loss over 40 years

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Ramseier, Christoph A., Anerud, Age, Dulac, Mary, Lulic, Martina, Cullinan, Mary P., Seymour, Gregory J., Faddy, Malcolm J., Bürgin, Walter +2 more·2017·Journal of Clinical Periodontology
DOI 10.1111/jcpe.12782
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Abstract

OBJECTIVES: To assess long-term attachment and periodontitis-related tooth loss (PTL) in untreated periodontal disease over 40 years. MATERIAL AND METHODS: Data originated from the natural history of periodontitis study in Sri Lankan tea labourers first examined in 1970. In 2010, 75 subjects (15.6%) of the original cohort were re-examined. RESULTS: PTL over 40 years varied between 0 and 28 teeth (mean 13.1). Four subjects presented with no PTL, while 12 were edentulous. Logistic regression revealed attachment loss as a statistically significant covariate for PTL (p < .004). Markov chain analysis showed that smoking and calculus were associated with disease initiation and that calculus, plaque, and gingivitis were associated with loss of attachment and progression to advanced disease. Mean attachment loss <1.81 mm at the age of 30 yielded highest sensitivity and specificity (0.71) to allocate subjects into a cohort with a dentition of at least 20 teeth at 60 years of age. CONCLUSIONS: These results highlight the importance of treating early periodontitis along with smoking cessation, in those under 30 years of age. They further show that calculus removal, plaque control, and the control of gingivitis are essential in preventing disease progression, further loss of attachment and ultimately tooth loss.

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  • Manual dexterity difficulties and adherence challenges decrease the effectiveness of guideline-conformed periodontitis treatment in a large part of the affected population.

    “Manual dexterity difficulties in the latter and challenges with adherence decrease the effectiveness of guidelines conformed treatment in a large part of the affected population, who got the disease due to inadequate oral hygiene practices (Lang et al., 2009; Ramseier et al., 2017).”

    From Enhanced control of periodontitis by an artificial intelligence‐enabled multimodal‐sensing toothbrush and targeted <scp>mHealth</scp> micromessages: A randomized trial (2024) · cites this paper as Ramseier et al., 2017

    The Factors influencing the initiation and progression of chronic periodontitis section (page unavailable) links higher plaque indices to disease progression, supporting the sentence’s point about inadequate oral hygiene. But the paper studies an untreated cohort; it does not assess manual dexterity, treatment adherence, or whether either reduces the effectiveness of guideline-conformed treatment in a large part of the affected population. (LLM, conf=0.82)

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  1. Harris, K. (2010) ROC Hard? No, ROC Made Easy. In: Proceedings of the SAS Global Forum 2010 Conference.

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Authors
Ramseier, C. A., Anerud, A., Dulac, M., Lulic, M., Cullinan, M. P., Seymour, G. J., Faddy, M. J., Bürgin, W., Schätzle, M., & Lang, N. P.
Affiliations
  • University of Bern (CH)
  • The University of Honk Kong Hong Kong China
  • University of Hong Kong (HK)
  • The University of Queensland (AU)
  • Queensland University of Technology (AU)
  • University of Zurich (CH)
Corresponding author
Lang, Niklaus P.
ORCID
Venue
Journal of Clinical Periodontology
Publisher
Wiley
Published
2017-09-22
Volume
44
Issue
12
Pages
1182-1191
ISSN
  • 0303-6979 (ISSN-L)
  • 1600-051X
DOI
10.1111/jcpe.12782
OpenAlex
W2738605185
Cited by
264
References
24
Citations by year
2026: 13 · 2025: 43 · 2024: 46 · 2023: 39 · 2022: 34 · 2021: 36 · 2020: 27 · 2019: 17 · 2018: 7 · 2017: 2
FWCI
20.00
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal Of Clinical Periodontology (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Cancer Research Foundation
  • Society of Surgical Oncology
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
periodontitis, tooth loss, attachment loss, disease progression, smoking, dental calculus, dental plaque, gingivitis, edentulism, Markov chain analysis
MeSH terms
Adolescent, Adult, Areca, Dental Calculus, Dental Plaque, Gingivitis, Habits, Hong Kong, Humans, Jaw, Edentulous, Partially, Longitudinal Studies, Male, Markov Chains, Mouth, Edentulous, Periodontal Diseases, Periodontal Index, Periodontitis, Risk Factors, Sensitivity and Specificity, Smoking, Time Factors, Logistic Models, Tooth Loss, Smoking Cessation, Periodontal Attachment Loss, Disease Progression, Chronic Periodontitis, Young Adult

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