Preventive intervention for trauma reactions in young injured children: Results of a multi-site randomised controlled trial
Abstract
BACKGROUND: Young children are at particular risk for injury. Ten per cent to twenty-five per cent develop posttraumatic stress disorder (PTSD). However, no empirically supported preventive interventions exist. Therefore, this study evaluated the efficacy of a standardised targeted preventive intervention for PTSD in young injured children. METHODS: Injured children (1-6 years) were enrolled in a multi-site parallel-group superiority prospective randomised controlled trial (RCT) in Australia and Switzerland. Screening for PTSD risk occurred 6-8 days postaccident. Parents of children who screened 'high-risk' were randomised to a 2-session CBT-based intervention or treatment-as-usual (TAU). Primary outcomes were PTSD symptom (PTSS) severity, and secondary outcomes were PTSD diagnosis, functional impairment and behavioural difficulties at 3 and 6 months postinjury using blinded assessments. Trials were registered with the Australian New Zealand Clinical Trials Registry (ACTRN12614000325606) and ClinicalTrials.gov (NCT02088814). Trial status is complete. RESULTS: One hundred and thirty-three children screened 'high-risk' were assigned to intervention (n = 62) or TAU (n = 71). Multilevel intention-to-treat analyses revealed a significant intervention effect on PTSS severity over time (b = 60.06, 95% CI: 21.30-98.56). At 3 months, intervention children (M = 11.02, SD = 10.42, range 0-47) showed an accelerated reduction in PTSS severity scores compared to control children (M = 17.30, SD = 13.94, range 0-52; mean difference -6.97, 95% CI: -14.02 to 0.08, p adj. = .055, d = 0.51). On secondary outcomes, multilevel analyses revealed significant treatment effects for PTSD diagnosis, functional impairment and behavioural difficulties. CONCLUSIONS: This multi-site RCT provides promising preliminary evidence for the efficacy of a targeted preventive intervention for accelerating recovery from PTSS in young injured children. This has important clinical implications for the psychological support provided to young children and parents during the acute period following a single-event trauma.
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A targeted preventive intervention reduces PTSD symptom severity over time, particularly with early intervention for young children.
“Researchers in the study [30] discuss the sustained benefits of a targeted preventive intervention in reducing PTSD symptom severity over time, particularly emphasizing early intervention for young children.”
From Clinical Efficacy of Psychotherapeutic Interventions for Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Analysis. (2024) · cites this paper as [30]
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Fitting Linear Mixed-Effects Models Using <b>lme4</b>
Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015) · Journal of Statistical Software · doi:10.18637/jss.v067.i01 · Cited by 86,835 · see citing works
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971 · see citing works
Manual for the ASEBA preschool forms and profiles
Achenbach, T. M., & Rescorla, L. A. (2000) · Cited by 1,678 · see citing works
The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms
Gouin, J., & Kiecolt‐Glaser, J. K. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.09.010 · Cited by 452 · see citing works
Kazak, A. E. (2006) · Families Systems & Health · doi:10.1037/1091-7527.24.4.381 · Cited by 407 · see citing works
Handling missing data in RCTs; a review of the top medical journals
Bell, M. L., Fiero, M., Horton, N. J., & Hsu, C.-H. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-118 · Cited by 395 · see citing works
Berkowitz, S. J., Stover, C. S., & Marans, S. R. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02321.x · Cited by 277 · see citing works
Bakker, A., Maertens, K., van Son, M. J. M., & Loey, N. E. E. V. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.12.006 · Cited by 233 · see citing works
Meiser‐Stedman, R., Smith, P. A., Glucksman, E., Yule, W., & Dalgleish, T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07081282 · Cited by 216 · see citing works
Scheeringa, M. S., & Haslett, N. (2010) · Child Psychiatry & Human Development · doi:10.1007/s10578-009-0169-2 · Cited by 211 · see citing works
Building child trauma theory from longitudinal studies: A meta-analysis
Alisic, E., Jongmans, M. J., van Wesel, F., & Kleber, R. J. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.03.001 · Cited by 187 · see citing works
Prevalence, comorbidity and course of trauma reactions in young burn‐injured children
Young, A. D., Kenardy, J. A., Cobham, V. E., & Kimble, R. M. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02431.x · Cited by 177 · see citing works
The role of parenting behaviors in childhood post-traumatic stress disorder: A meta-analytic review
Williamson, V., Creswell, C., Fearon, P. R. M., Hiller, R. M., Walker, J., & Halligan, S. L. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.01.005 · Cited by 170 · see citing works
European report on child injury prevention.
Sethi, D. D., Towner, E., Vincenten, J. A., Seguí‐Gómez, M., & Racioppi, F. (2008) · World Health Organization, Regional Office for Europe eBooks · Cited by 166 · see citing works
Young, A. D., Hendrikz, J. K., Kenardy, J. A., Cobham, V. E., & Kimble, R. M. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0066 · Cited by 135 · see citing works
PTSD in Children Below the Age of 6 Years
Young, A. D., & Landolt, M. A. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0966-z · Cited by 82 · see citing works
Modeling Site Effects in the Design and Analysis of Multi-site Trials
Feaster, D. J., Mikulich‐Gilbertson, S. K., & Brincks, A. M. (2011) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2011.600386 · Cited by 80 · see citing works
Zehnder, D., Meuli, M., & Landolt, M. A. (2010) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-4-7 · Cited by 75 · see citing works
Evaluation of an Early Risk Screener for PTSD in Preschool Children After Accidental Injury
Kramer, D. N., Hertli, M. B., & Landolt, M. A. (2013) · PEDIATRICS · doi:10.1542/peds.2013-0713 · Cited by 52 · see citing works
Segal, L., Guy, S., & Furber, G. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417717796 · Cited by 50 · see citing works
Ybarra, G. J., Passman, R. H., & Eisenberg, C. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.2.322 · Cited by 49 · see citing works
Posttraumatic Stress Disorder in Young Children 3 Years Posttrauma
Meiser‐Stedman, R., Smith, P. A., Yule, W., Glucksman, E., & Dalgleish, T. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m10002 · Cited by 35 · see citing works
PTSD Perpetuates Pain in Children With Traumatic Brain Injury
Brown, E. A., Kenardy, J. A., & Dow, B. L. (2014) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsu014 · Cited by 34 · see citing works
Haag, A., & Landolt, M. A. (2017) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsx059 · Cited by 34 · see citing works
Kramer, D. N., & Landolt, M. A. (2014) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v5.24402 · Cited by 29 · see citing works
Young, A. D., Haag, A., Kenardy, J. A., Kimble, R. M., & Landolt, M. A. (2016) · Trials · doi:10.1186/s13063-016-1490-2 · Cited by 25 · see citing works
Evaluation of an Early Risk Screener for PTSD in Preschool Children After Accidental Injury
(2013) · PEDIATRICS · doi:10.1542/peds.2013-0713d · Cited by 24 · see citing works
Ybarra, G. J., Passman, R. H., & Eisenberg, C. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.68.2.322 · Cited by 23 · see citing works
Trauma and PTSD in Preschool-Aged Children
Haag, A., Celi, S., & Landolt, M. A. (2019) · Routledge eBooks · doi:10.4324/9781315213828-8 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Topical Review: Medical Trauma During Early Childhood
Young, A. D., Paterson, R., Brown, E. A., Egberts, M. R., Brocque, R. M. L., Kenardy, J. A., Landolt, M. A., Marsac, M. L., Alisic, E., & Haag, A. (2021) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsab045 · Cited by 53 · see citing works
Kerbage, H., Bazzi, O., El‐Hage, W., Corruble, E., & Purper‐Ouakil, D. (2022) · Healthcare · doi:10.3390/healthcare10050818 · Cited by 40 · see citing works
Gkintoni, E., Kourkoutas, E., Yotsidi, V., Stavrou, P. D., & Prinianaki, D. (2024) · Children · doi:10.3390/children11050579 · Cited by 37 · see citing works
“Moreover, an independent study [30] presents the main findings of the research, which involve an analysis of variables that can forecast, assess, and manage PTSD in adolescents.”
BackgroundAfzal, N., Ye, S., Page, A. C., Trickey, D., Lyttle, M. D., Hiller, R. M., & Halligan, S. L. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008066.2022.2156053 · Cited by 35 · see citing works
Hitchcock, C., Goodall, B., Wright, I. M., Boyle, A. A., Johnston, D., Dunning, D. L., Gillard, J., Griffiths, K., Humphrey, A., McKinnon, A., et al. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13460 · Cited by 22 · see citing works
Evidence-Based Treatments for Children and Adolescents
Landolt, M. A., & Kenardy, J. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-97802-0_20 · Cited by 21 · see citing works
Posttraumatic stress disorder in burn patient: A systematic review
Paggiaro, A. O., Paggiaro, P. B. S., Fernandes, R. Á. Q., Freitas, N. O., de Carvalho, V. F., & Gemperli, R. (2022) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2022.02.052 · Cited by 19 · see citing works
Korpilahti-Leino, T., Luntamo, T., Ristkari, T., Hinkka‐Yli‐Salomäki, S., Pulkki-Råbäck, L., Waris, O., Matinolli, H., Sinokki, A., Mori, Y., Fukaya, M., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/26438 · Cited by 17 · see citing works
Early Intervention After Trauma
Bryant, R. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-97802-0_7 · Cited by 14 · see citing works
The Management of Burn Pain in a Pediatric Burns-Specialist Hospital
Storey, K., Kimble, R. M., & Holbert, M. D. (2021) · Pediatric Drugs · doi:10.1007/s40272-020-00434-y · Cited by 13 · see citing works
Ma, J., Hu, D., Feng, Z., Tang, J., Guo, L., Du, Y., & Quan, J. (2020) · International Wound Journal · doi:10.1111/iwj.13478 · Cited by 12 · see citing works
Afzal, N., Lyttle, M. D., Rajabi, M., Rushton-Smith, F., Varghese, R., Trickey, D., Halligan, S. L., & (PERUKI), O. B. O. T. P. E. R. I. T. U. A. I. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2023.2300586 · Cited by 8 · see citing works
Bartels, L., Sachser, C., & Landolt, M. A. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1948788 · Cited by 7 · see citing works
Comparative Effectiveness of Parent-Based Interventions to Support Injured Children
Ramirez, M. R., Flores, J. E., Woods-Jaeger, B. A., Cavanaugh, J. E., Peek-Asa, C. L., Branch, C. A., Bolenbaugh, M., Chande, V. T., Pitcher, G., Ortega, H. W., et al. (2021) · PEDIATRICS · doi:10.1542/peds.2020-046920 · Cited by 6 · see citing works
Risk factors for PTSD symptoms following PICU admission for childhood septic shock
Burcher, G. C., O’Dea, L. A., Cooper, M. K., Lancaster, R., McCutcheon, R. A., Garralda, M. E., & Nadel, S. (2024) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-024-02496-6 · Cited by 5 · see citing works
Stauffer, A., Petermann, F., Metzner, F., & Vasileva, M. (2020) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000402 · Cited by 5 · see citing works
Early Childhood Educators: The Forgotten Tier
McGoey, K. E., Dirsmith, J., Jancart, K. L., Vecchiarelli, J., & Hanchon, T. A. (2022) · Perspectives on early childhood psychology and education /Perspectives on early childhood psychology and education · doi:10.58948/2834-8257.1013 · Cited by 4 · see citing works
Dimanopoulos, M. T. A., Trenoweth, K., Young, A. D., Kimble, R. M., & Griffin, B. R. (2025) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2025.01.027 · Cited by 3 · see citing works
Co-design of a paediatric post-trauma electronic psychosocial screen
Griffin, B. R., Trenoweth, K., Dimanopoulos, T. A., Young, A. D., Cobham, V. E., Williams, H., & Kimble, R. M. (2024) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2024.02.004 · Cited by 3 · see citing works
Ewing‐Cobbs, L., Cox, C. S., Clark, A. E., & Keenan, H. T. (2025) · Journal of Neurotrauma · doi:10.1089/neu.2024.0578 · Cited by 3 · see citing works
Parent-Child EMDR therapy for children aged 0–4 years: Protocol, pilot-data, and case study
Went, M. A. M., Struik, A., Möller, E. L., Zijlstra, B. J. H., Dumoulin, A., van Haaften, M. A. G., & Rodenburg, R. (2024) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2024.100475 · Cited by 3 · see citing works
Posttraumatic stress disorder interventions for children aged zero to six years: a scoping review
Murphy, S. J., Malcolmson, E. K., McEwan, K., & McGrath, P. J. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2553429 · Cited by 1 · see citing works
Annual Research Review: Interventions for young children exposed to trauma
Guyon‐Harris, K. L., & Humphreys, K. L. (2026) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.70121 · Cited by 1 · see citing works
Philippine, V., Soubelet, A., Ferrandez, S., & Askenazy-Gittard, F. (2026) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2026.100641 · Cited by 1 · see citing works
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de Haan, A., Perrin, S. G., Smith, P. A., & Yule, W. (2021) · Comprehensive Clinical Psychology · doi:10.1016/b978-0-12-818697-8.00094-7 · Cited by 1 · see citing works
Masalha, B., Ben-David, S., Benarroch, F., & Ben-Ari, A. (2022) · Children · doi:10.3390/children9040526 · Cited by 1 · see citing works
Bartels, L., Haag, A., Keller, F., Storch, E. A., Young, A. D., Salloum, A., & Landolt, M. A. (2022) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-022-09985-5 · Cited by 1 · see citing works
Schwebel, D. C., Barton, B. K., Shen, J., & Stavrinos, D. (2023) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsad055 · Cited by 1 · see citing works
Simons, M., Harvey, G., McMillan, L., Ryan, E., Young, A. D., McPhail, S., Kularatna, S., Senanayake, S. J., Kimble, R. M., & Tyack, Z. F. (2024) · Burns · doi:10.1016/j.burns.2024.03.032 · Cited by 1 · see citing works
Brief Cognitive-Behavioral Therapy for Pediatric Health Conditions
Reuther, E. T., & Canavera, K. E. (2024) · CBT: science into practice · doi:10.1007/978-3-031-60746-2_12 · Cited by 1 · see citing works
Preventive Early Intervention for Children and Adolescents Exposed to Trauma
Young, A. D., Keleher, S., Baldwin, A. R., & Kenardy, J. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-77215-3_6 · Cited by 2 · see citing works
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Marsac, M. L., Hildenbrand, A. K., & Kassam‐Adams, N. (2024) · Springer eBooks · doi:10.1007/978-3-031-77215-3_23
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Landolt, M. A., Cloître, M., & Schnyder, U. (2024) · Springer eBooks · doi:10.1007/978-3-031-77215-3_28
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Vasileva, M., Landolt, M. A., & Young, A. D. (2024) · Springer eBooks · doi:10.1007/978-3-031-77215-3_19
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August, D. L., Hall, S., Marsh, N. M., Chapple, L., Cobbald, L., Lai, M., Hall, D., Koorts, P. J., Xu, H. G., Cunninghame, J., et al. (2025) · International Wound Journal · doi:10.1111/iwj.70745
Woodson, L. C., McQuitty, A. L., Martyn, J. A. J., Talon, M. D., & Sherwood, E. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-88389-4.00021-x
Evaluating trauma-informed care practices in pediatric trauma activations using video review
McKay, K. G., Chawla, E., Greeno, A. L., Lovvorn, H. N., & Maiga, A. W. (2026) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2026.117228
Ray, M., Bailey, A., Lendrum, E. C., Vore, E., Poundstone, A., Beiting, S. E., Reichert, M., Moody, S. M., Rheaume, E. M., Falcone, R. A., et al. (2026) · Injury · doi:10.1016/j.injury.2026.113767
Smolović, V., Milojević, G., Петровић, М., Stanković, M., & Puška, A. (2026) · International Journal of Offender Therapy and Comparative Criminology · doi:10.1177/0306624x261496931
- Authors
- Haag, A., Landolt, M. A., Kenardy, J. A., Schiestl, C. M., Kimble, R. M., & De Young, A. C.
- Affiliations
- University of Zurich (CH)
- The University of Queensland (AU)
- University Children's Hospital Zurich (CH)
- School of Psychology University of Queensland Brisbane QLD Australia
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2020-01-08
- Volume
- 61
- Issue
- 9
- Pages
- 988-997
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W3000651695
- Cited by
- 40
- References
- 32
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 12 · 2023: 1 · 2022: 8 · 2021: 7 · 2020: 2
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (100014_149158)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child Therapy and Development
- Keywords
- post-traumatic stress disorder, children, injuries, preventive interventions, cognitive behavioral therapy, trauma response, PTSD symptom severity, functional disability, behavioral problems, parental support
- MeSH terms
- Psychological Trauma, Adult, Australia, Child, Child, Preschool, Female, Humans, Infant, Male, Parents, Stress Disorders, Post-Traumatic
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