Difference in the prevalence of gestational diabetes mellitus according to gestational age at 75‐g oral glucose tolerance test in Japan: The Japan Assessment of Gestational Diabetes Mellitus Screening trial
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Aims/Introduction: To evaluate the differences in the results of 75‐g oral glucose tolerance tests (OGTT s) according to gestational age in Japan. Materials and Methods: In this prospective cohort study, 2,578 pregnant women were divided into three categories based on their gestational age during the 75‐g OGTT: <14 weeks’ gestation, 14–23 weeks’ gestation and 24–32 weeks’ gestation. The association between gestational age and the results of the 75‐g OGTT were evaluated using multivariable analysis. Results: Early gestational age was associated with high fasting plasma glucose levels at the time of the 75‐g OGTT, and low corresponding 1‐h and 2‐h plasma glucose levels. Compared with women with a gestational age of 24–32 weeks, women who had undergone the 75‐g OGTT at <14 weeks’ gestation had significantly higher odds of gestational diabetes mellitus diagnosis based on the currently used criteria in Japan (adjusted odds ratio 1.42, 95% confidence interval 1.07–1.90). Conclusions: The results of the 75‐g OGTT varied by gestational age. The use of the same 75‐g OGTT cut‐off values for the diagnosis of gestational diabetes mellitus, regardless of gestational age, might lead to increases in the prevalence of gestational diabetes mellitus diagnosis in Japan.
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Blood glucose levels during 75-g OGTT differ between early and late pregnancy.
“Indeed, our research has shown that blood glucose levels during 75‐g OGTT differ between early and late pregnancy 12 .”
From Clinical challenges in early pregnancy in Japan: An update on gestational diabetes (2024) · cites this paper as [12]
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Clinical challenges in early pregnancy in Japan: An update on gestational diabetes
Sugiyama, T., Kawasaki, M., & Arata, N. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14319
Self-citation
- Authors
- Iwama, N., Sugiyama, T., Metoki, H., Kusaka, H., Yaegashi, N., Sagawa, N., Hiramatsu, Y., Toyoda, N., & The JAGS Group
- Affiliations
- Tohoku University Hospital (JP)
- Ehime University (JP)
- Tohoku Medical and Pharmaceutical University (JP)
- Mie Chuo Medical Center (JP)
- Tohoku University (JP)
- Rakuwakai Otowa Hospital (JP)
- Okayama Medical Center (JP)
- Suzuka University of Medical Science (JP)
- Corresponding author
- Sugiyama, Takashi
- Venue
- Journal of Diabetes Investigation
- Publisher
- Wiley
- Published
- 2019-04-19
- Volume
- 10
- Issue
- 6
- Pages
- 1576-1585
- ISSN
- 2040-1116 (ISSN-L)
- 2040-1124
- PMC
- PMC6825953
- OpenAlex
- W2924984869
- Cited by
- 24
- References
- 3
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 1
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Diabetes Investigation (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (19K09825, 16K11092)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- gestational diabetes mellitus, gestational age, 75 g oral glucose tolerance test, diagnostic thresholds, fasting blood glucose, gestational diabetes screening
- MeSH terms
- Adult, Blood Glucose, Female, Follow-Up Studies, Gestational Age, Glucose Tolerance Test, Humans, Japan, Pregnancy, Prognosis, Prospective Studies, Biomarkers, Prevalence, Diabetes, Gestational, Risk Assessment
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