Community pharmacist interventions to improve adherence to lipid lowering medication and their influence on clinical outcomes: A systematic review and meta‐analysis
Abstract
Introduction Non-adherence is a major problem among patients with chronic diseases. Community pharmacists are ideally positioned to detect non-adherence and to provide patient-centred interventions. Objective To conduct a systematic review of the impact of community pharmacist interventions on patient adherence to lipid lowering medication (LLM) prescriptions and clinical outcomes. Search method Five databases (MEDLINE, Cochrane Library, Science Direct, Scopus, and Web of Knowledge) were searched systematically to identify relevant reports published by December 2019. Study quality was assessed with the Cochrane risk of bias (RoB 2.0) tool. Selection criteria Controlled trials in which community pharmacists conducted an intervention to improve patient adherence to LLM and clinical outcomes were evaluated. Main results Five studies (2408 participants) were included in the qualitative analysis. Four studies (n = 2266) were pooled in the meta-analysis. Participants in the intervention group (IG) had better adherence than those in the control group (CG) [odds ratio (OR) = 1.67; 95% confidence interval (CI) 1.38-2.02; P 2 = 54%]. Better adherence rates were obtained when adherence was measured with validated questionnaires than when medication-possession ratio (MPR) measurements were used. Total cholesterol (TC) levels were not included in the meta-analysis due to data variability among the studies. Conclusions Pharmacist-led intervention can improve LLM adherence, but its influenc…
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Oñatibia-Astibia et al., 2021 focused on the potential of community pharmacist interventions on improving adherence to LLMs and clinical outcomes, but their impact on clinically-relevant outcomes remains insufficiently explored.
“Oñatibia-Astibia et al., 2021 focused on the potential of community pharmacist interventions on improving adherence to LLMs and clinical outcomes.7 However, their impact on clinically-relevant outcomes remains insufficiently explored.”
From Interventions to improve adherence to lipid-lowering drugs: a systematic review and meta-analysis (2025) · cites this paper as [7]
Cites
RoB 2: a revised tool for assessing risk of bias in randomised trials
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., et al. (2019) · BMJ · doi:10.1136/bmj.l4898 · Cited by 33,583 · see citing works
Ho, P. M., Rumsfeld, J. S., Masoudi, F. A., McClure, D. L., Plomondon, M. E., Steiner, J. F., & Magid, D. J. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1836 · Cited by 1,135 · see citing works
Fernandez-Lazaro, C. I., García-González, J. M., Adams, D. P., Fernandez-Lazaro, D., Mielgo-Ayuso, J., Caballero-Garcia, A., Moreno Racionero, F., Córdova, A., & Miron-Canelo, J. A. (2019) · BMC Family Practice · doi:10.1186/s12875-019-1019-3 · Cited by 321 · see citing works
Analysis of the reporting of search strategies in Cochrane systematic reviews
Yoshii, A., Plaut, D. A., McGraw, K. A., Anderson, M. J., & Wellik, K. E. (2009) · Journal of the Medical Library Association : JMLA · doi:10.3163/1536-5050.97.1.004 · Cited by 137 · see citing works
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Interventions to improve adherence to lipid-lowering drugs: a systematic review and meta-analysis
Yow, D. K. W., Ang, W. J., Yap, H. J., Ito, S., Liu, J., Ko, J., Tan, D. S.-Y., Lorenzatti, A., & Ang, C.-S. (2025) · eClinicalMedicine · doi:10.1016/j.eclinm.2025.103270 · Cited by 5 · see citing works
- Authors
- Oñatibia‐Astibia, A., Malet‐Larrea, A., Gastelurrutia, M. Á., Calvo, B., & Goyenechea, E.
- Affiliations
- University of the Basque Country (ES)
- Official Pharmacist Association of Gipuzkoa San Sebastian Spain
- Universidad de Granada (ES)
- Corresponding author
- Oñatibia‐Astibia, Ainhoa
- Venue
- Journal of Evaluation in Clinical Practice
- Publisher
- Wiley
- Published
- 2020-09-02
- Volume
- 27
- Issue
- 2
- Pages
- 451-463
- ISSN
- 1356-1294 (ISSN-L)
- 1365-2753
- OpenAlex
- W3083530269
- Cited by
- 23
- References
- 4
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Evaluation in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- community pharmacists, pharmacist intervention, medication adherence, lipid-lowering drugs, hyperlipidemia, cholesterol management, medication possession ratio, adherence questionnaires, clinical outcomes
- MeSH terms
- Humans, Lipids, Pharmacists, Medication Adherence
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