Effect of Medication Nonadherence on Hospitalization and Mortality Among Patients With Diabetes Mellitus
Abstract
BACKGROUND: Medication nonadherence may reduce the effectiveness of therapies. To our knowledge, the association between medication nonadherence and mortality remains unexplored outside the context of clinical trials. METHODS: A retrospective cohort study of 11 532 patients with diabetes mellitus in a managed care organization. Medication adherence was calculated as the proportion of days covered for filled prescriptions of oral hypoglycemics, antihypertensives, and statin medications. The primary outcomes of interest were all-cause hospitalization and all-cause mortality. Multivariable regression analyses were performed to assess the independent association between medication adherence and outcomes. RESULTS: Nonadherent patients (proportion of days covered, <80%; prevalence, 21.3%) were younger and had fewer comorbidities compared with adherent patients. During follow-up, nonadherent patients had higher glycosylated hemoglobin, systolic and diastolic blood pressure, and low-density lipoprotein cholesterol levels. In unadjusted analyses, nonadherent patients had higher all-cause hospitalization (23.2% vs 19.2%, P<.001) and higher all-cause mortality (5.9% vs 4.0%, P<.001). In multivariable analyses, medication nonadherence remained significantly associated with increased risks for all-cause hospitalization (odds ratio, 1.58; 95% confidence interval, 1.38-1.81; P<.001) and for all-cause mortality (odds ratio, 1.81; 95% confidence interval, 1.46-2.23; P<.001). The findings were consistent across patient subgroups and using different cutoffs for the proportion of days covered. CONCLUSIONS: Medication nonadherence is prevalent among patients with diabetes mellitus and is associated with adverse outcomes. Interventions are needed to increase medication adherence so that patients can realize the full benefit of prescribed therapies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nonadherence in type 2 diabetes is independently associated with poor glycemic control, increased rates of vascular, renal, and other complications, and mortality.
“Nonadherence in T2D is independently associated with poor glycemic control, increased rates of vascular, renal, and other complications, and mortality [7, 8, 11].”
From Positive Psychological Interventions for Patients with Type 2 Diabetes: Rationale, Theoretical Model, and Intervention Development (2015) · cites this paper as [7]
Most patients with type 2 diabetes have suboptimal adherence to recommended diet, physical activity, and/or medication.
“Most patients with type 2 diabetes (T2D) have suboptimal adherence to recommended diet, physical activity, and/or medication.”
From Positive Psychological Interventions for Patients with Type 2 Diabetes: Rationale, Theoretical Model, and Intervention Development (2015) · cites this paper as [7]
Cites
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,672 · see citing works
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
Adherence to Long-Term Therapies: Evidence for Action
Geest, S. D., & Sabate, E. J. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00091-4 · Cited by 6,274 · see citing works
Impact of Medication Adherence on Hospitalization Risk and Healthcare Cost
Sokol, M. C., McGuigan, K. A., Verbrugge, R. R., & Epstein, R. S. (2005) · Medical Care · doi:10.1097/01.mlr.0000163641.86870.af · Cited by 1,729 · see citing works
Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
Selvin, E., Marinopoulos, S., Berkenblit, G., Rami, T., Brancati, F. L., Powe, N. R., & Golden, S. H. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-6-200409210-00007 · Cited by 1,657 · see citing works
Long-term persistence in use of statin therapy in elderly patients
Benner, J. S. (2002) · JAMA · doi:10.1001/jama.288.4.455 · Cited by 1,232 · see citing works
A systematic review of adherence with medications for diabetes
Cramer, J. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1218 · Cited by 1,203 · see citing works
Pharmacologic Therapy for Type 2 Diabetes Mellitus
DeFronzo, R. A. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-4-199908170-00008 · Cited by 1,173 · see citing works
Estacio, R. O., Jeffers, B. W., Hiatt, W. R., Biggerstaff, S. L., Gifford, N., & Schrier, R. W. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803053381003 · Cited by 1,158 · see citing works
A Diabetes Report Card for the United States: Quality of Care in the 1990s
Saaddine, J., Engelgau, M., Beckles, G., Gregg, E., Thompson, T., & Narayan, K. M. V. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-8-200204160-00005 · Cited by 638 · see citing works
The Multilevel Compliance Challenge: Recommendations for a Call to Action
Miller, N. H., Hill, M. N., Kottke, T. E., & Ockene, I. S. (1997) · Circulation · doi:10.1161/01.cir.95.4.1085 · Cited by 493 · see citing works
Granger, B. B., Swedberg, K. B., Ekman, I., Granger, C. B., Olofsson, B., McMurray, J. J. V., Yusuf, S., Michelson, E. L., & Pfeffer, M. A. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67760-4 · Cited by 475 · see citing works
A General Method of Compliance Assessment Using Centralized Pharmacy Records
Steiner, J. F., Koepsell, T. D., Fihn, S. D., & Inui, T. S. (1988) · Medical Care · doi:10.1097/00005650-198808000-00007 · Cited by 458 · see citing works
Self-citationTreatment adherence and risk of death after a myocardial infarction
Horwitz, R. I., Viscoli, C. M., Donaldson, R. M., Murray, C. J. L., Ransohoff, D. F., Horwitz, R. I., Berkman, L. F., Horwitz, S. M., Ransohoff, D. F., & Sindelar, J. L. (1990) · The Lancet · doi:10.1016/0140-6736(90)92095-y · Cited by 453 · see citing works
Krousel-Wood, M. A., Thomas, S., Muntner, P., & Morisky, D. E. (2004) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000126978.03828.9e · Cited by 417 · see citing works
Clinical Outcomes and Adherence to Medications Measured by Claims Data in Patients With Diabetes
Pladevall, M., Williams, L. K., Potts, L. A., Divine, G., Xi, H., & Lafata, J. E. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2800 · Cited by 404 · see citing works
Balkrishnan, R., Rajagopalan, R., Camacho, F. T., Huston, S. A., Murray, F. T., & Anderson, R. T. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80347-8 · Cited by 350 · see citing works
Lau, D. T., & Nau, D. P. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2149 · Cited by 317 · see citing works
Li, W., Wang, J., Thompson, P., Wong, S., Struthers, A. D., & MacDonald, T. M. (2002) · Heart · doi:10.1136/heart.88.3.229 · Cited by 294 · see citing works
Kerr, E. A., Gerzoff, R. B., Krein, S. L., Selby, J. V., Piette, J. D., Curb, J. D., Herman, W. H., Marrero, D. G., Narayan, K. M. V., Safford, M. M., et al. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-4-200408170-00007 · Cited by 291 · see citing works
Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes
Hu, G., Jousilahti, P., Barengo, N. C., Qiao, Q., Lakka, T. A., & Tuomilehto, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.799 · Cited by 265 · see citing works
Heisler, M., Smith, D. M., Hayward, R. A., Krein, S. L., & Kerr, E. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.738 · Cited by 180 · see citing works
(2004) · PubMed · Cited by 119 · see citing works
Poor Adherence to Placebo or Amiodarone Therapy Predicts Mortality
Irvine, J., Baker, B., Smith, J. L., Jandciu, S., Paquette, M., Cairns, J. A., Connolly, S. J., Roberts, R., Gent, M., & Dorian, P. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199907000-00023 · Cited by 113 · see citing works
Rc, T., Cull, C. A., Frighi, V., & Holman, R. R. (1999) · The Endocrinologist · doi:10.1097/00019616-199911000-00013 · Cited by 112 · see citing works
Task Force #4—adherence issues and behavior changes: achieving a long-term solution
Ockene, I. S., Hayman, L. L., Pasternak, R. C., SCHRON, E. B., & Dunbar‐Jacob, J. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02078-8 · Cited by 101 · see citing works
Patient adherence: the next frontier in quality improvement
Heidenreich, P. A. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.03.007 · Cited by 74 · see citing works
O'Donovan, G., Owen, A., Kearney, E. M., Jones, D. W., Nevill, A. M., Woolf-May, K., & Bird, S. R. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803004 · Cited by 61 · see citing works
Wei, L., Flynn, R., Murray, G. D., & MacDonald, T. M. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.963 · Cited by 53 · see citing works
Nonadherence as a predictor of antidiabetic drug therapy intensification (augmentation)
Kogut, S. J., Andrade, S. E., Willey, C. J., & Larrat, E. P. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1005 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 2,605 · see citing works
Medication Adherence: Its Importance in Cardiovascular Outcomes
Ho, P. M., Bryson, C. L., & Rumsfeld, J. S. (2009) · Circulation · doi:10.1161/circulationaha.108.768986 · Cited by 1,488 · see citing works
Self-citationTing, D. S. W., Cheung, G. C. M., & Wong, T. Y. (2016) · Clinical & Experimental Ophthalmology · doi:10.1111/ceo.12696 · Cited by 1,066 · see citing works
Ho, P. M. (2009) · JAMA · doi:10.1001/jama.2009.261 · Cited by 1,004 · see citing works
Self-citationRasmussen, J. N., Chong, A., & Alter, D. A. (2007) · JAMA · doi:10.1001/jama.297.2.177 · Cited by 975 · see citing works
Incidence and Prognosis of Resistant Hypertension in Hypertensive Patients
Daugherty, S. L., Powers, J. D., Magid, D. J., Tavel, H. M., Masoudi, F. A., Margolis, K. L., O'Connor, P. J., Selby, J. V., & Ho, P. M. (2012) · Circulation · doi:10.1161/circulationaha.111.068064 · Cited by 930 · see citing works
Self-citationPolonsky, W., & Henry, R. (2016) · Patient Preference and Adherence · doi:10.2147/ppa.s106821 · Cited by 784 · see citing works
The Lancet Commission on diabetes: using data to transform diabetes care and patient lives
Chan, J. C. N., Lim, L.-L., Wareham, N. J., Shaw, J. E., Orchard, T. J., Zhang, P., Lau, E. S. H., Eliasson, B., Kong, A. P. S., Ezzati, M., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32374-6 · Cited by 793 · see citing works
We need minimally disruptive medicine
May, C. R., Montori, V. M., & Mair, F. S. (2009) · BMJ · doi:10.1136/bmj.b2803 · Cited by 739 · see citing works
Adherence to Therapies in Patients with Type 2 Diabetes
García‐Pérez, L., Álvarez, M., Dilla, T., Gil-Guillén, V. F., & Orozco‐Beltrán, D. (2013) · Diabetes Therapy · doi:10.1007/s13300-013-0034-y · Cited by 738 · see citing works
Mazzaglia, G., Ambrosioni, E., Alacqua, M., Filippi, A., Sessa, E., Immordino, V., Borghi, C., Brignoli, O., Caputi, A. P., Cricelli, C., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.830299 · Cited by 637 · see citing works
Good and poor adherence: optimal cut-point for adherence measures using administrative claims data.
Karve, S., Cleves, M. A., Helm, M., Hudson, T. J., West, D. S., & Martin, B. C. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903126833 · Cited by 620 · see citing works
Comparison of drug adherence rates among patients with seven different medical conditions
Briesacher, B. A., Andrade, S. E., Fouayzi, H., & Chan, K. A. (2008) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.28.4.437 · Cited by 587 · see citing works
Ho, P. M., Magid, D. J., Shetterly, S. M., Olson, K. L., Maddox, T. M., Peterson, P. N., Masoudi, F. A., & Rumsfeld, J. S. (2008) · American Heart Journal · doi:10.1016/j.ahj.2007.12.011 · Cited by 587 · see citing works
Self-citationPrimary Medication Non-Adherence: Analysis of 195,930 Electronic Prescriptions
Fischer, M. A., Stedman, M. R., Lii, J., Vogeli, C., Shrank, W. H., Brookhart, M. A., & Weissman, J. S. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-010-1253-9 · Cited by 573 · see citing works
Dosing Frequency and Medication Adherence in Chronic Disease
Coleman, C. I., Limone, B. L., Sobieraj, D. M., Lee, S., Roberts, M. S., Kaur, R., & Alam, T. (2012) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2012.18.7.527 · Cited by 438 · see citing works
Etxeberría, U., de la Garza, A. L., Campión, J., Martínez, J. A., & Milagro, F. I. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.664134 · Cited by 398 · see citing works
Ho, P. M. (2008) · JAMA · doi:10.1001/jama.299.5.532 · Cited by 391 · see citing works
Self-citationBetter compliance to antihypertensive medications reduces cardiovascular risk
Corrao, G., Parodi, A., Nicotra, F., Zambon, A., Merlino, L., Cesana, G., & Mancia, G. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328342ca97 · Cited by 367 · see citing works
Eton, D. T., de Oliveira, D. R., Egginton, J. S., Ridgeway, J. L., Odell, L., May, C. R., & Montori, V. M. (2012) · Patient Related Outcome Measures · doi:10.2147/prom.s34681 · Cited by 361 · see citing works
Gonzalez, J. S., Tanenbaum, M. L., & Commissariat, P. V. (2016) · American Psychologist · doi:10.1037/a0040388 · Cited by 354 · see citing works
Gehi, A. K. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.16.1798 · Cited by 339 · see citing works
The Lancet Commission on diabetes: using data to transform diabetes care and patient lives
Chan, J. C. N., Lim, L., Wareham, N. J., Shaw, J. E., Orchard, T. J., Zhang, P., Lau, E. S. H., Eliasson, B., Kong, A. P. S., Ezzati, M., et al. (2020) · Figshare · Cited by 337 · see citing works
The Implications of Therapeutic Complexity on Adherence to Cardiovascular Medications
Choudhry, N. K., Fischer, M. A., Avorn, J., Liberman, J. N., Schneeweiß, S., Pakes, J., Brennan, T. A., & Shrank, W. H. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.495 · Cited by 310 · see citing works
Broadbent, E., Donkin, L., & Stroh, J. C. (2011) · Diabetes Care · doi:10.2337/dc10-1779 · Cited by 304 · see citing works
Motivational Interviewing Improves Medication Adherence: a Systematic Review and Meta-analysis
Palacio, A., Garay, D., Langer, B., Taylor, J., WOOD, B. A., & Tamariz, L. J. (2016) · Journal of General Internal Medicine · doi:10.1007/s11606-016-3685-3 · Cited by 292 · see citing works
Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review
De Vera, M. A., Bhole, V., Burns, L. C., & Lacaille, D. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12339 · Cited by 289 · see citing works
Type 2 Diabetes in the Real World: The Elusive Nature of Glycemic Control
Edelman, S. V., & Polonsky, W. H. (2017) · Diabetes Care · doi:10.2337/dc16-1974 · Cited by 289 · see citing works
Impact of Medication Nonadherence on Hospitalizations and Mortality in Heart Failure
Fitzgerald, A. A., Powers, J. D., Ho, P. M., Maddox, T. M., Peterson, P. N., Allen, L. A., Masoudi, F. A., Magid, D. J., & Havranek, E. P. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.04.011 · Cited by 282 · see citing works
Self-citationEffectiveness of disease-management programs for improving diabetes care: a meta-analysis
Pimouguet, C., Goff, M. L., Thiébaut, R., Jf, D., & Helmer, C. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091786 · Cited by 276 · see citing works
Tran, V.-T., Montori, V. M., Eton, D. T., Baruch, D., Falissard, B., & Ravaud, P. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-68 · Cited by 278 · see citing works
Medication Taking and Diabetes
Odegard, P. S., & Capoccia, K. L. (2007) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721707308407 · Cited by 274 · see citing works
Arora, S., Peters, A. L., Burner, E., Lam, C. N., & Menchine, M. (2014) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2013.10.012 · Cited by 273 · see citing works
Gender and racial disparities in adherence to statin therapy: A meta-analysis
Lewey, J., Shrank, W. H., Bowry, A. D. K., Kilabuk, E., Brennan, T. A., & Choudhry, N. K. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.02.011 · Cited by 267 · see citing works
Patient adherence to medication requirements for therapy of type 2 diabetes
Bailey, C. J., & Kodack, M. (2011) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02544.x · Cited by 255 · see citing works
How patient cost-sharing trends affect adherence and outcomes: a literature review.
Eaddy, M. T., Cook, C. L., O'Day, K., Burch, S. P., & Cantrell, C. R. (2012) · Europe PMC (PubMed Central) · Cited by 246 · see citing works
Rosbach, M., & Andersen, J. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179916 · Cited by 245 · see citing works
Depression and Cardiovascular Disorders
Whooley, M. A., & Wong, J. M. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185526 · Cited by 241 · see citing works
Schmittdiel, J. A., Uratsu, C. S., Karter, A. J., Heisler, M., Subramanian, U., Mangione, C. M., & Selby, J. V. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0554-8 · Cited by 239 · see citing works
Health Literacy Explains Racial Disparities in Diabetes Medication Adherence
Osborn, C. Y., Cavanaugh, K. L., Wallston, K. A., Kripalani, S. B., Elasy, T. A., Rothman, R. L., & White, R. O. (2011) · Journal of Health Communication · doi:10.1080/10810730.2011.604388 · Cited by 238 · see citing works
Ogedegbe, G. O. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.1307 · Cited by 230 · see citing works
Safren, S. A., Gonzalez, J. S., Wexler, D. J., Psaros, C., Delahanty, L. M., Blashill, A. J., Margolina, A. I., & Cagliero, E. (2013) · Diabetes Care · doi:10.2337/dc13-0816 · Cited by 233 · see citing works
Association between adherence to pharmacotherapy and outcomes in type 2 diabetes: a meta-analysis
Khunti, K., Seidu, S., Kunutsor, S., & Davies, M. (2017) · Diabetes Care · doi:10.2337/dc16-1925 · Cited by 231 · see citing works
Sweileh, W., Zyoud, S., Nab'a, R. J. A., Deleq, M., Enaia, M., Nassar, S. M., & Al-Jabi, S. W. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-94 · Cited by 250 · see citing works
Clinical and economic impact of non-adherence in COPD: A systematic review
van Boven, J. F. M., Chavannes, N. H., van der Molen, T., Mölken, M. R., Postma, M. J., & Vegter, S. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.08.044 · Cited by 225 · see citing works
Diabetes knowledge, medication adherence and glycemic control among patients with type 2 diabetes
Al-Qazaz, H., Sulaiman, S. A. S., Hassali, M. A., Shafie, A. A., Sundram, S., Al-Nuri, R., & Saleem, F. (2011) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-011-9582-2 · Cited by 226 · see citing works
Eton, D. T., Yost, K. J., Lai, J., Ridgeway, J. L., Egginton, J. S., Rosedahl, J. K., Linzer, M., Boehm, D. H., Thakur, A., Poplau, S., et al. (2016) · Quality of Life Research · doi:10.1007/s11136-016-1397-0 · Cited by 221 · see citing works
Kashtoh, H., & Baek, K.-H. (2023) · Plants · doi:10.3390/plants12162944 · Cited by 213 · see citing works
Depression, medication adherence, and service utilization in systemic lupus erythematosus
Julian, L. J., Yelin, E. H., Yazdany, J., Panopalis, P., Trupin, L. S., Criswell, L. A., & Katz, P. (2009) · Arthritis Care & Research · doi:10.1002/art.24236 · Cited by 193 · see citing works
Medication Adherence in Healthy Elders: Small Cognitive Changes Make a Big Difference
Hayes, T. L., Larimer, N., Adami, A., & Kaye, J. A. (2009) · Journal of Aging and Health · doi:10.1177/0898264309332836 · Cited by 192 · see citing works
Distress and type 2 diabetes-treatment adherence: A mediating role for perceived control.
Gonzalez, J. S., Shreck, E., Psaros, C., & Safren, S. A. (2014) · Health Psychology · doi:10.1037/hea0000131 · Cited by 194 · see citing works
Axelsson, M., Brink, E., Lundgren, J., & Lötvall, J. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018241 · Cited by 188 · see citing works
Xie, Z., Liu, K., Or, C., Chen, J., Yan, M., & Wang, H. (2020) · BMC Public Health · doi:10.1186/s12889-020-09274-4 · Cited by 184 · see citing works
Gislason, G., Rasmussen, J. N., Abildstrom, S. Z., Schramm, T. K., Hansen, M. L., Buch, P., Sørensen, R., Folke, F., Gadsbøll, N., Rasmussen, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.669101 · Cited by 182 · see citing works
Gellad, W. F., Haas, J. S., & Safran, D. G. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0385-z · Cited by 181 · see citing works
Chen, C., Tseng, C., & Cheng, S. (2012) · Medical Care · doi:10.1097/mlr.0b013e31827da5b9 · Cited by 183 · see citing works
Diabetes mellitus and severe mental illness: mechanisms and clinical implications
Holt, R. I. G., & Mitchell, A. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.203 · Cited by 181 · see citing works
Karve, S. J., Cleves, M. A., Helm, M. E., Hudson, T. J., West, D. S., & Martin, B. C. (2008) · Medical Care · doi:10.1097/mlr.0b013e31817924d2 · Cited by 176 · see citing works
Kim, S., Shin, D. W., Yun, J. M., Hwang, Y., Park, S. K., Ko, Y.-J., & Cho, B. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06731 · Cited by 178 · see citing works
Jha, A. K., Aubert, R. E., Yao, J., Teagarden, J. R., & Epstein, R. S. (2012) · Health Affairs · doi:10.1377/hlthaff.2011.1198 · Cited by 174 · see citing works
Interventions for self-management of type 2 diabetes: An integrative review
Carpenter, R., DiChiacchio, T., & Barker, K. (2019) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2018.12.002 · Cited by 170 · see citing works
Babel, A., Taneja, R., Mondello Malvestiti, F., Monaco, A., & Donde, S. (2021) · Frontiers in Digital Health · doi:10.3389/fdgth.2021.669869 · Cited by 199 · see citing works
Understanding patient portal use: implications for medication management
Osborn, C. Y., Mayberry, L. S., Wallston, K. A., Johnson, K. B., & Elasy, T. A. (2013) · Journal of Medical Internet Research · doi:10.2196/jmir.2589 · Cited by 147 · see citing works
Ridgeway, J. L., Eton, D. T., Egginton, J. S., Tiedje, K., Linzer, M., Boehm, D. H., Poplau, S., de Oliveira, D. R., Odell, L., & Montori, V. M. (2014) · Patient Preference and Adherence · doi:10.2147/ppa.s58014 · Cited by 168 · see citing works
New Prescription Medication Gaps: A Comprehensive Measure of Adherence to New Prescriptions
Karter, A. J., Parker, M. M., Moffet, H. H., Ahmed, A. T., Schmittdiel, J. A., & Selby, J. V. (2009) · Health Services Research · doi:10.1111/j.1475-6773.2009.00989.x · Cited by 166 · see citing works
Medication adherence: emerging use of technology
Granger, B. B., & Bosworth, H. B. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328347c150 · Cited by 165 · see citing works
Trouble Getting Started: Predictors of Primary Medication Nonadherence
Fischer, M. A., Choudhry, N. K., Brill, G. E., Avorn, J., Schneeweiß, S., Hutchins, D. S., Liberman, J. N., Brennan, T. A., & Shrank, W. H. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.05.028 · Cited by 165 · see citing works
Borne, R. T., O’Donnell, C. I., Turakhia, M. P., Varosy, P. D., Jackevicius, C. A., Marzec, L., Masoudi, F. A., Hess, P. L., Maddox, T. M., & Ho, P. M. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0671-6 · Cited by 158 · see citing works
Self-citationEton, D. T., Ridgeway, J. L., Egginton, J. S., Tiedje, K., Linzer, M., Boehm, D. H., Poplau, S., de Oliveira, D. R., Odell, L., Montori, V. M., et al. (2015) · Patient Related Outcome Measures · doi:10.2147/prom.s78955 · Cited by 154 · see citing works
Barriers to Medication Adherence in Poorly Controlled Diabetes Mellitus
Odegard, P. S., & Gray, S. L. (2008) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721708320558 · Cited by 152 · see citing works
Longitudinal effects of medication nonadherence on glycemic control
Egede, L. E., Gebregziabher, M., Echols, C., & Lynch, C. P. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028014526362 · Cited by 146 · see citing works
Predictors of medication adherence in patients with type 2 diabetes mellitus
Curkendall, S. M., Thomas, N., Bell, K. F., Juneau, P. L., & Weiss, A. J. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.821056 · Cited by 149 · see citing works
Sex differences in the risk of vascular disease associated with diabetes
de Ritter, R., de Jong, M., Vos, R. C., Kallen, C., Sep, S. J. S., Woodward, M., Stehouwer, C. D. A., Bots, M. L., & Peters, S. A. E. (2020) · Biology of Sex Differences · doi:10.1186/s13293-019-0277-z · Cited by 151 · see citing works
Salmasi, S., Loewen, P. S., Tandun, R., Andrade, J. G., & Vera, M. A. D. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034778 · Cited by 154 · see citing works
Health App Use Among US Mobile Phone Users: Analysis of Trends by Chronic Disease Status
Robbins, R., Krebs, P. M., Jagannathan, R., Jean‐Louis, G., & Duncan, D. T. (2017) · JMIR mhealth and uhealth · doi:10.2196/mhealth.7832 · Cited by 144 · see citing works
Effects of Structured Versus Usual Care on Renal Endpoint in Type 2 Diabetes: The SURE Study
Chan, J. C. N., So, W., Yeung, C., Ko, G. T. C., Lau, I. T., Tsang, M.-W., Lau, K.-P., Siu, S.-C., Li, J. K., Yeung, M. W., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1908 · Cited by 145 · see citing works
Yang, Y., Thumula, V., Pace, P. F., Banahan, B. F., Wilkin, N. E., & Lobb, W. B. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.10.002 · Cited by 139 · see citing works
Tan, J., Cheng, K., & Siah, R. C. J. (2019) · Journal of Advanced Nursing · doi:10.1111/jan.14025 · Cited by 116 · see citing works
Effect of Unrelated Comorbid Conditions on Hypertension Management
Turner, B. J., Hollenbeak, C. S., Weiner, M., Have, T. T., & Tang, S. S. K. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-8-200804150-00002 · Cited by 140 · see citing works
Carls, G. S., Tuttle, E., Tan, R.-D., Huynh, J., Yee, J., Edelman, S. V., & Polonsky, W. H. (2017) · Diabetes Care · doi:10.2337/dc16-2725 · Cited by 153 · see citing works
P4P4P: An Agenda For Research On Pay-For-Performance For Patients
Volpp, K. G., Pauly, M. V., Loewenstein, G., & Bangsberg, D. (2009) · Health Affairs · doi:10.1377/hlthaff.28.1.206 · Cited by 136 · see citing works
A systematic review of patient-reported measures of burden of treatment in three chronic diseases
Eton, D. T., Elraiyah, T. A., Yost, K. J., Ridgeway, J. L., Johnson, A., Egginton, J. S., Mullan, R. J., Murad, M. H., Erwin, P. J., & Montori, V. M. (2013) · Patient Related Outcome Measures · doi:10.2147/prom.s44694 · Cited by 135 · see citing works
Feldman, C. H., Yazdany, J., Guan, H., Solomon, D. H., & Costenbader, K. H. (2015) · Arthritis Care & Research · doi:10.1002/acr.22636 · Cited by 134 · see citing works
Diabetes Performance Measures: Current Status and Future Directions
O’Connor, P. J., Bodkin, N. L., FRADKIN, J. E., Glasgow, R. E., Greenfield, S., Gregg, E. W., Kerr, E. A., Pawlson, L. G., Selby, J. V., Sutherland, J. E., et al. (2011) · Diabetes Care · doi:10.2337/dc11-0735 · Cited by 134 · see citing works
Kamuhabwa, A. A. R., & Charles, E. (2014) · Drug Healthcare and Patient Safety · doi:10.2147/dhps.s68786 · Cited by 133 · see citing works
Lo‐Ciganic, W., Gellad, W. F., Gordon, A. J., Cochran, G., Zemaitis, M. A., Cathers, T., Kelley, D., & Donohue, J. M. (2015) · Addiction · doi:10.1111/add.13270 · Cited by 132 · see citing works
Patient perspectives on once‐weekly medications for diabetes
Polonsky, W. H., Fisher, L., Hessler, D., Bruhn, D. F., & Best, J. H. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01327.x · Cited by 131 · see citing works
Simpson, R. J., & Mendys, P. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.08.026 · Cited by 131 · see citing works
The ARMS-D out performs the SDSCA, but both are reliable, valid, and predict glycemic control
Mayberry, L. S., Gonzalez, J. S., Wallston, K. A., Kripalani, S. B., & Osborn, C. Y. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.09.010 · Cited by 129 · see citing works
Huffman, J. C., DuBois, C. M., Millstein, R. A., Celano, C. M., & Wexler, D. (2015) · Journal of Diabetes Research · doi:10.1155/2015/428349 · Cited by 127 · see citing works
Pednekar, P. P., Ágh, T., Malmenäs, M., Raval, A. D., Bennett, B. M., Borah, B. J., Hutchins, D. S., Manias, E., Williams, A. F., Hiligsmann, M., et al. (2018) · Value in Health · doi:10.1016/j.jval.2018.08.006 · Cited by 129 · see citing works
Weiss, T., Carr, R. D., Pal, S., Yang, L., Sawhney, B., Boggs, R., Rajpathak, S., & Iglay, K. (2020) · Patient Preference and Adherence · doi:10.2147/ppa.s277676 · Cited by 126 · see citing works
A systematic overview of systematic reviews evaluating medication adherence interventions
Anderson, L. J., Nuckols, T. K., Coles, C., Le, M. M., Schnipper, J. L., Shane, R., Jackevicius, C., Lee, J., Pevnick, J. M., Members of the PHARM-DC Group, et al. (2020) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxz284 · Cited by 122 · see citing works
Sinnott, S.-J., Buckley, C., O′Riordan, D., Bradley, C., & Whelton, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064914 · Cited by 124 · see citing works
du Vaure, C. B., Ravaud, P., Baron, G., Barnes, C., Gilberg, S., & Boutron, I. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010119 · Cited by 125 · see citing works
Derivation and validation of the ASK-12 adherence barrier survey
Matza, L. S., Park, J., Coyne, K. S., Skinner, E. P., Malley, K. G., & Wolever, R. Q. (2009) · Annals of Pharmacotherapy · doi:10.1345/aph.1m174 · Cited by 117 · see citing works
Medication adherence and glycemic control among newly diagnosed diabetes patients
Lin, L.-K., Sun, Y., Heng, B. H., Chew, D. E. K., & Chong, P.-N. (2017) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2017-000429 · Cited by 123 · see citing works
Nelson, L. A., Wallston, K. A., Kripalani, S. B., LeStourgeon, L. M., Williamson, S., & Mayberry, L. S. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.046 · Cited by 126 · see citing works
The relationship of depression to antiepileptic drug adherence and quality of life in epilepsy
Ettinger, A. B., Good, M. B., Manjunath, R., Faught, E., & Bancroft, T. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.05.011 · Cited by 120 · see citing works
Salas, M., Hughes, D. A., Zuluaga, A., Vardeva, K., & Lebmeier, M. (2009) · Value in Health · doi:10.1111/j.1524-4733.2009.00539.x · Cited by 119 · see citing works
- Authors
- Ho, P. M., Rumsfeld, J. S., Masoudi, F. A., McClure, D. L., Plomondon, M. E., Steiner, J. F., & Magid, D. J.
- Affiliations
- Denver VA Medical Center (US)
- ORCID
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2006-09-25
- Volume
- 166
- Issue
- 17
- Pages
- 1836
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2156108549
- Cited by
- 1,135
- References
- 34
- Citations by year
- 2026: 15 · 2025: 38 · 2024: 41 · 2023: 57 · 2022: 49 · 2021: 60 · 2020: 58 · 2019: 63 · 2018: 76 · 2017: 63 · 2016: 81 · 2015: 75 · 2014: 93 · 2013: 60 · 2012: 75
- FWCI
- 23.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K08-AG01011, K08AG001011)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
- Keywords
- medication non-adherence, diabetes mellitus, hospitalization, all-cause mortality, proportion of days covered, oral hypoglycemics, antihypertensive drugs, statins, HbA1c, blood pressure, LDL cholesterol, managed care
- MeSH terms
- Administration, Oral, Aged, Antihypertensive Agents, Blood Pressure, Diabetes Mellitus, Female, Glycated Hemoglobin, Hospitalization, Humans, Hypoglycemic Agents, Cholesterol, LDL, Male, Middle Aged, Mortality, Retrospective Studies, Treatment Refusal, Hydroxymethylglutaryl-CoA Reductase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
