Cited by 505Intensive Care Unit Cognitive DisordersAlcoholism and Thiamine DeficiencyAnesthesia and Sedative Agents

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Antipsychotic medication for prevention and treatment of delirium in hospitalized adults: a systematic review and meta-analysis

Open access

Neufeld, Karin J., Yue, Jirong, Robinson, Thomas N., Inouye, Sharon K., Needham, Dale M.·2016·Journal of the American Geriatrics Society

DOI 10.1111/jgs.14076PMC PMC4840067

Open this paper in CoChat — free account

Abstract

Objectives: To evaluate the effectiveness of antipsychotic medications in preventing and treating delirium. Design: Systematic review and meta‐analysis. Setting: PubMed, EMBASE , CINAHL , and ClinicalTrials.gov databases were searched from January 1, 1988, to November 26, 2013. Participants: Adult surgical and medical inpatients. Intervention: Antipsychotic administration for delirium prevention or treatment in randomized controlled trials or cohort studies. Measurements: Two authors independently reviewed all citations, extracted relevant data, and assessed studies for potential bias. Heterogeneity was considered as chi‐square P < .1 or I 2 > 50%. Using a random‐effects model (I 2 > 50%) or a fixed‐effects model (I 2 < 50%), odds ratios ( OR s) were calculated for dichotomous outcomes (delirium incidence and mortality), and mean or standardized mean difference for continuous outcomes (delirium duration, severity, hospital and intensive care unit ( ICU ) length of stay ( LOS )). Sensitivity analyses included postoperative prevention studies only, exclusion of studies with high risk of bias, and typical versus atypical antipsychotics. Results: Screening of 10,877 eligible records identified 19 studies. In seven studies comparing antipsychotics with placebo or no treatment for delirium prevention after surgery, there was no significant effect on delirium incidence ( OR = 0.56, 95% confidence interval ( CI ) = 0.23–1.34, I 2 = 93%). Using data reported from all 19 studies, antipsychotic use was not associated with change in delirium duration, severity, or hospital or ICU LOS , with high heterogeneity among studies. No association with mortality was detected ( OR = 0.90, 95% CI = 0.62–1.29, I 2 = 0%). Conclusion: Current evidence does not support the use of antipsychotics for prevention or treatment of delirium. Additional methodologically rigorous studies using standardized outcome measures are needed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/jgs.14076

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Delirium in elderly people
Inouye, S. K., Westendorp, R. G., & Saczynski, J. S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60688-1 · Cited by 3,722
Self-citation
Delirium in Elderly Patients and the Risk of Postdischarge Mortality, Institutionalization, and Dementia
Witlox, J., Eurelings, L. S. M., de Jonghe, J. F. M., Kalisvaart, K. J., Eikelenboom, P., & van Gool, W. A. (2010) · JAMA · doi:10.1001/jama.2010.1013 · Cited by 1,972
The case of the misleading funnel plot
Lau, J., Ioannidis, J. P. A., Terrin, N., Schmid, C. H., & Olkin, I. (2006) · BMJ · doi:10.1136/bmj.333.7568.597 · Cited by 1,766
One-Year Health Care Costs Associated With Delirium in the Elderly Population
LESLIE, D. L. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.4 · Cited by 1,038
Validation of the Delirium Rating Scale-Revised-98
Trzepacz, P. T., D, D. M. M., Torres, R. A. M., Kanary, K., Norton, J., & Jimerson, N. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.2.229 · Cited by 957 · cited 2×
“Delirium severity was evaluated using the Delirium Rating Scale (DRS)(10) or the DRS Revised-98.(11) When specific data could not be obtained directly from the publications (n = 4), authors were contacted, with all providing additional statistics.”
Method
Antipsychotic Dose Equivalents and Dose-Years: A Standardized Method for Comparing Exposure to Different Drugs
Andreasen, N. C., Pressler, M., Nopoulos, P., Miller, D. D., & Ho, B. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.040 · Cited by 956
A symptom rating scale for delirium
Trzepacz, P. T., Baker, R. W., & Greenhouse, J. B. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90037-6 · Cited by 655
Haloperidol Prophylaxis for Elderly Hip‐Surgery Patients at Risk for Delirium: A Randomized Placebo‐Controlled Study
Kalisvaart, K. J., de Jonghe, J. F. M., Bogaards, M. J., Vreeswijk, R., Egberts, T. C. G., Burger, B. J., Eikelenboom, P., & van Gool, W. A. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53503.x · Cited by 636 · cited 4×
“The current results were consistent with the findings of a meta-analysis(34) that included three RCTs of haloperidol versus placebo.(18,19,23) No association between antipsychotics and prevention of postoperative delirium was demonstrated.”
BackgroundResultInfluential

Flagged first, then by citations

Show all 46 references

Sorted by citations

Items 401–500 of 504

The challenge of managing severe delirium: an observational study of the effects of pharmacological and supportive care on delirium duration and resolution in 602 patientsPreprint
Zipser, C. M., Hayoz, P., Knoepfel, S., Peyk, P., Schubert, M., von Känel, R., & Böettger, S. (2019) · doi:10.21203/rs.2.18810/v1
“The liberal administration of psychotropics in patients with delirium was recently challenged in a systematic review that incorporated 19 randomized controlled trials [23].”
Background
Delirium
Gurnani, A. S. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_960-1
Delirium
Steele, L., & Aperis, G. (2018) · British Journal of Hospital Medicine · doi:10.12968/hmed.2018.79.9.c138
Intensive Care in Older Adult Surgery Patients
Jones, T. S., & Robinson, T. (2020) · Springer eBooks · doi:10.1007/978-3-319-47771-8_26
Self-citation
Confusion mentale
Reich, M., Razavi, D., Lossignol, D., & Delvaux, N. (2019) · Elsevier eBooks · doi:10.1016/b978-2-294-75811-9.00008-8
Encephalopathy
Lewis, S. L. (2021) · Springer eBooks · doi:10.1007/978-3-030-75778-6_15
Cognitive impairment
Baxter, J., & Young, L. (2022) · doi:10.1093/med/9780198766223.003.0043
Alternativas para la sedación, analgesia, relajación y delirium en pacientes COVID-19. Revisión narrativa
Ferrer, L., Díaz, J. C., Cardenas, Y., Vergara, P., Portilla, M. R., Fernández, M. G., VALENCIA, B. A. G., Vargas, M., Flórez, H. J. M., & Castell, C. R. D. (2022) · Medicina Crítica · doi:10.35366/106512 · Cited by 1
Palliativversorgung im finalen Tumorstadium: Sinnvolle Strategien für die Versorgung im Delir
Gärtner, J., Gahr, S., Reinholz, U., Kunz, R., Jentschke, E., & Roch, C. (2022) · Deutsches Ärzteblatt · doi:10.3238/personko.2022.12.02.02
Management of Post-nephrectomy Delirium in Patients with Traumatic Renal Rupture: A Case Report
(2022) · Journal of Medical Case Reports and Case Series · doi:10.38207/jmcrcs/2022/dece031701124
DELIRIUM: NARRATIVE REVIEW
Rincon, A. N. P., Conde-Rodríguez, B. D., Palacos, S. R., Casablanco, J. L., Garcia, T. P. P. E., Sánchez, V. R., & Díaz, M. A. D. (2022) · GLOBAL JOURNAL FOR RESEARCH ANALYSIS · doi:10.36106/gjra/3207226
Munkánk értelmét és a reményt a közös küzdelem adja : Szabó Lajos Időskori demenciák családi, társadalmi és pszichológiai vonatkozásai című könyvéről
Madár, C. (2022) · Máltai Tanulmányok · doi:10.56699/mt.2022.4.12
Delirium and Cognitive Impairment
Alici, Y., Böettger, S., & BREITBART, W. S. (2022) · doi:10.1093/med/9780197615935.003.0005
Eficacia de las intervenciones no farmacológicas para la prevención del delirium en personas ancianas hospitalizadas: una revisión sistemática
Bastida, J. D., Checa-Guillamón, I., García-Lidón, E., Font, S. J., Mercadal-Fañanas, P., & Arroyo-Cardona, E. (2023) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2023.03.002
Looking at Psychiatric Medications When Individuals Undergo Liver Transplant
Mills, J., & Karkhang, C. C. (2023) · Issues in Mental Health Nursing · doi:10.1080/01612840.2023.2204800
“Some literature has cast doubt on antipsychotics’ ability to combat delirium (Neufeld et al., 2016), but experts have commented that even if a medication such as olanzapine cannot overtly prevent or resolve delirium, it may still be useful in offering relief from debilitating symptoms such as…”
Background
Faktor-Faktor yang Berhubungan dengan Persepsi Masyarakat Urban Terhadap Program Vaksinasi Nasional COVID-19 di Kota Sumbawa Besar Provinsi NTB
Hutomo, F. P. (2023) · COMSERVA Jurnal Penelitian dan Pengabdian Masyarakat · doi:10.59141/comserva.v2i09.597
Delirium
Evans, B. D., & Hickey, E. J. (2021) · doi:10.1093/med/9780197559321.003.0049
Altered Mental Status and Neurologic Syndromes
Heinrich, T. W., Steele, I. C., & Brady, S. J. (2023) · Oxford University Press eBooks · doi:10.1093/med/9780197624005.003.0007
Geriatrics
Cho, D., Takeshita, J., Huynh, V., Gomes, I., & Hishinuma, E. S. (2023) · doi:10.1093/med/9780197624005.003.0016
Síndrome confusional en la persona anciana
Rouet, A., Ketz, F., Boddaert, J., & Verny, M. (2023) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(23)47964-0
Optimizing Pharmacotherapy in Older Patients: Delirium
Bellelli, G., & Morandi, A. (2023) · Practical issues in geriatrics · doi:10.1007/978-3-031-28061-0_14
Prevention and management of delirium in hospital
Wijayabandara, M., Millawithana, B., & Lamabadusuriya, D. A. (2023) · Journal of the Ceylon College of Physicians · doi:10.4038/jccp.v54i1.7999
“Another meta-analysis demonstrated no significant effect on delirium incidence, duration, severity, length of stay or mortality.(16) Thus, they are recommended in the lowest effective asneeded doses for the shortest duration to manage highdistress symptoms such as severe agitation and psychosis with cautious monitorin…”
Background
Delirium
Bellelli, G., & Morandi, A. (2023) · Springer eBooks · doi:10.1007/978-3-030-01782-8_89-1
The Association of Nonmodifiable Patient Factors on Antipsychotic Medication use in the Intensive Care Unit
Connell, J. M., McCann, B., Feng, X., Shotwell, M. S., Hughes, C. G., & Boncyk, C. S. (2023) · Journal of Intensive Care Medicine · doi:10.1177/08850666231198030
Effects of Opioids, Steroids, Benzodiazepines, Anticholinergics, and Antihistamines on the Efficacy of Antipsychotics for Treating Delirium in End-of-Life Adult Patients Undergoing Palliative Care
Sato, J., & Tanaka, R. (2023) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360288.2023.2253241
“However, the efficacy of these antipsychotics is inadequate (16); moreover, unfa-vourable prognostic effects have been noted with haloperidol and risperidone (19) Furthermore, Gaudreau et al. investigated background factors in 43 of 261 hospitalized cancer patients who developed delirium.”
Background
Postoperative delirium: Addressing the rising scourge in healthcare
Nwosu, A. D. G. (2021) · Ibom Medical Journal · doi:10.61386/imj.v14i3.55
Levomepromazine and Weaning from Sedation in Traumatic Brain Injured Patients
Benaddi, L., -, M. F., -, M. E., Berdai, G., -, A. M. A., -, A. N., & Alharrar, R. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i05.6625
“No specific treatment is currently recommended for the management of delirium, largely due to a lack of efficacy data [3].”
Background
Treatment of delirious mania with catatonia in a community teaching hospital: A case series
Wheeler, T., & Vasan, S. (2023) · Psychiatry Research Case Reports · doi:10.1016/j.psycr.2023.100190
What Framework Can Be Used to Address Uncontrolled Symptoms at the End of Life?
Kezar, C. E., Downer, K., & Tucker, R. O. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-84702-5.00061-0
Do Caregivers Hava an Effect Extended Hospitalization in Patient Fallowed Palliative Care Center? A Study From TurkeyPreprint
Çakmak, N. Y. (2023) · Research Square · doi:10.21203/rs.3.rs-3468911/v1
Manual de condutas em cuidados paliativos na atenção primária à saúde
da Silva, L. L., Ikuta, Y. M., Dias, L. M., Vallinoto, M. C., Gobbi, C. D., & Duarte, H. P. P. (2023) · doi:10.22533/at.ed.620231611
Delirium
Bellelli, G., & Morandi, A. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_89
Uso de olanzapina por catéter subcutáneo para control de delirium de difícil manejo: reporte de caso
Severiche, L. J. R., Gaviria, E. R., Pinto, A. N. C., Osorio, M. A. O., Sarria, N. C., Quevedo, E. A. A., & Lugo, G. F. O. (2024) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2023.12.001
Postoperatives Delir im Aufwachraum
Rudy, M., & Saller, T. (2024) · Wiener klinisches Magazin · doi:10.1007/s00740-024-00522-6
Do Caregivers Have an Effect on Extended Hospitalization in Patient-Fallowed Palliative Care Center? A Study from Turkey.Preprint
Çakmak, N. Y., & Bozkuş, R. (2024) · Research Square · doi:10.21203/rs.3.rs-3468911/v2
Do antipsychotics increase the risk of morbidity and mortality in adult hospitalized patients?
Wallman, J., Bifom, A., McEwan, K., Okon, D., & Schwertman, K. (2024) · Evidence-Based Practice · doi:10.1097/ebp.0000000000001924
Delirium
Hategan, A., Hirsch, C. H., Bourgeois, J. A., & Francis, D. C. (2024) · Springer eBooks · doi:10.1007/978-3-031-47802-4_17
Systematic Literature Review on early detection of Postoperative Delirium in Patients with Cardiovascular DiseasePreprint
Othman, S. M. A., Aziz, M. A. A., & Qin, X. U. (2024) · Research Square · doi:10.21203/rs.3.rs-4355605/v1
AVANÇOS E DESAFIOS NO MANEJO DA COMPULSÃO ALIMENTAR: PERSPECTIVAS ATUAIS E FUTURAS
Francisco, A. R. V., Gomes, F. O. M., Costa, D. M. C., Luz, G. M. D. S., Júnior, P. R. H., & Júnior, H. S. D. F. (2024) · doi:10.22533/at.ed.7622414051
AVANÇOS NA COMPREENSÃO E TRATAMENTO DA DERMATITE LIQUENOIDE: UMA PERSPECTIVA INTEGRATIVA
Luz, G. M. D. S., Francisco, A. R. V., Gomes, F. O. M., Costa, D. M. C., Júnior, P. R. H., & Sousa, N. B. E. (2024) · doi:10.22533/at.ed.7622414052
ESTRATÉGIAS EDUCACIONAIS À DISTÂNCIA PARA MELHORIA DA SAÚDE DE INDIVÍDUOS COM DISTÚRBIOS CARDIOMETABÓLICOS PÓS-COVID
Vidal, L. S., Estácio, A. C. D. S., Miguel, E. A. A., do Nascimento, M. W., Silva, A. A. O., de Oliveira, K. G. M., & Barros, L. M. (2024) · doi:10.22533/at.ed.76224140512
O PERFIL FEMININO DAS MULHERES QUE FREQUENTAM O CAMPUS UFRJ MACAÉ - TRABALHADORES E ESTUDANTES: UM RELATO DE EXPERIÊNCIA
Mourão, L. J., Santos, A. R. S., Azevedo, L. D. A., Martins, L. D., Tavares, A., Neto, J. P., de Siqueira, P. R. A., Aguiar, M. C. D. S., Soares, G. R. D. S., Borges, F. C. Q., et al. (2024) · doi:10.22533/at.ed.76224140518
TRATAMENTO DE APENDICITE AGUDA NÃO OPERATÓRIA ATRAVÉS DO USO DE ANTIBIÓTICOS: UMA REVISÃO DE LITERATURA
Cazarim, L., & Júnior, H. S. D. F. (2024) · doi:10.22533/at.ed.76224140521
DIGITALIZAÇÃO DE EXAMES OBTIDOS DE UM EQUIPAMENTO ANALÓGICO DE ELETROCARDIOGRAMA EXISTENTE EM UM HOSPITAL UNIVERSITÁRIO (HUOL/UFRN) E SUA INTEGRAÇÃO COM O APLICATIVO DE GESTÃO HOSPITALAR
Nunes, N. G., Contreras, R. C., Cachina, M. L. D. M., de Queiroz, A. L. O., Guerra, Â. R. O., & Neto, C. L. D. B. G. (2024) · doi:10.22533/at.ed.7622414059
MEDICALIZAÇÃO DA VIDA E SUA INCIDÊNCIA SOBRE A INFÂNCIA
Bonfim, F. L. (2024) · doi:10.22533/at.ed.76224140516
MANEJO DA HIPERTENSÃO ARTERIAL SISTÊMICA NA ATENÇÃO PRIMÁRIA À SAÚDE: UMA ANÁLISE DOS SEUS AVANÇOS
Marassi, L. M., Júnior, P. R. H., & Júnior, H. S. D. F. (2024) · doi:10.22533/at.ed.76224140515
AVALIAÇÃO DO CENTRO DE NUTRIÇÃO E DIETÉTICA DE UM HOSPITAL DE PEQUENO PORTE - RISCOS VISÍVEIS AO OLHAR DA MICROBIOLOGIA
Oliveira, L. E. D. S., de Souza, A. C. H., Viana, A. R., da Silva, J. B., de Oliveira, A. W. M., Sampaio, A. D. D. S., Almeida‐Bezerra, J. W., Antunes, D. F., Pereira, A. L. G., Castro, J. W. G., et al. (2024) · doi:10.22533/at.ed.7622414054
DELIRIUM EM PACIENTES IDOSOS: PERSPECTIVAS ATUAIS SOBRE ETIOLOGIA, PREVENÇÃO E MANEJO
Teixeira, U. G., Sousa, M. S. E., Mafra, P. F., Ribeiro, J. C., Martines, L., Júnior, P. R. H., & Júnior, H. S. D. F. (2024) · doi:10.22533/at.ed.7622414058
AVANÇOS E DESAFIOS NO TRATAMENTO DA COVID-19: UMA REVISÃO DOS MEDICAMENTOS ANTIVIRAIS, ENFOQUE EM NIRMATRELVIR-RITONAVIR, VV116 E MONULPIRAVIR
Pimentel, F. M. Q. A., & Júnior, H. S. D. F. (2024) · doi:10.22533/at.ed.7622414055
PROGRAMA DE NAVEGAÇÃO MELHORA OS RESULTADOS DAS PACIENTES COM CÂNCER DE MAMA: EXPERIÊNCIA BRASILEIRA EM CENÁRIO REAL NO SISTEMA DE SAÚDE PÚBLICO
Gioia, S., Brigagão, L., Rocha, M., dos Santos, L., Messias, I. R., Carolina, J., Nascimento, A. D. S. R. D. S., Paulino, E., Nogueira‐Rodrigues, A., Park, B. H., et al. (2024) · doi:10.22533/at.ed.7622414056
O TRABALHO DIGNIFICA OU ADOECE O HOMEM? ESTUDO DE DISTÚRBIOS OSTEOMUSCULARES RELACIONADOS AO TRABALHO NA PERSPECTIVA RAMAZZINIANA
Savaris, A. D. A., Guarezi, I. D. F., de Oliveira, L. Z., & Lima, R. D. C. G. S. (2024) · doi:10.22533/at.ed.76224140519
EFEITOS DA ABORDAGEM FISIOTERAPÊUTICA NA SINTOMATOLOGIA DE PACIENTES EM CUIDADOS PALIATIVOS
Santos, A. P. A., Dias, D. S., Geike, E. E., & Simões, G. M. S. (2024) · doi:10.22533/at.ed.76224140510
PERSPECTIVA E HISTÓRIA DOS NÚCLEO DE APOIO A SAÚDE DA FAMÍLIA NO BRASIL
da Silva, R. N., de Menezes, T. A., & de Arruda, R. G. (2024) · doi:10.22533/at.ed.76224140520
CULTIVANDO SAÚDE: PLANTAS MEDICINAIS NA VIDA DA COMUNIDADE
Cordeiro, L. J. S., Rocha, G. Q. D. O., de Oliveira, M. M. S., de Freitas, L. L., Loiola, W. A., Santos, G. M. L. D. S., da Silva, J. F. L., Moraes, J. F., Silva, L. Q., de Miranda, J. C., et al. (2024) · doi:10.22533/at.ed.7622414057
FRAGILIDADES E POTENCIALIDADES EM EDUCAÇÃO EM SAÚDE PELA ÓTICA DE PROFISSIONAIS DE SAÚDE
Antero, M. B., & Messias, C. M. B. D. O. (2024) · doi:10.22533/at.ed.76224140514
EPIDEMIOLOGIA DAS INTERNAÇÕES POR DIABETES MELLITUS EM FORTALEZA, CE: ANÁLISE DOS DETERMINANTES SOCIAIS E AMBIENTAIS
Ponte, R. M. A., de Oliveira, A. A., Coutinho, A. B. A., Moraes, C. S., Rabelo, F. M., Neto, J. A., Feitosa, L. A. M., Osterno, M. I. R., Coutinho, M. C., Guimarães, R. V., et al. (2024) · doi:10.22533/at.ed.76224140511
ESTREPTOQUINASE MICROBIANA: AVANÇOS E PERSPECTIVAS NO TRATAMENTO DE DOENÇAS CARDIOVASCULARES
Sanches, B. P., Valentim, C. C., Assi, G. M., Mantovan, J., Bertoncini, G. E. S., & Baldo, C. (2024) · doi:10.22533/at.ed.76224140513
ANALISE DOS INIBIDORES SELETIVOS DA RECAPTAÇÃO DE SEROTONINA COMO TRATAMENTO DE PRESSÃO NA ATENÇÃO BÁSICA: UMA REVISÃO DE LITERATURA
Neves, S. C., & Sousa, N. B. E. (2024) · doi:10.22533/at.ed.7622414053
Ciências da saúde: bem-estar integral e qualidade de vida
Almeida‐Bezerra, J. W., & Martins, K. P. (2024) · doi:10.22533/at.ed.762241405
MODELO DE SESSÕES TEÓRICAS: ESTRATÉGIA PARA UNIFICAR TEORIA E PRÁTICA MÉDICA EM BUSCA DA INSERÇÃO DO ESTUDANTE DE MEDICINA NO ÂMBITO DA CIRURGIA BARIÁTRICA E METABÓLICA
Gomes, L. G. P. (2024) · doi:10.22533/at.ed.76224140517
Delirium
Patel, B., Hitching, R., & Sher, Y. I. (2024) · Springer eBooks · doi:10.1007/978-3-031-53976-3_6
Delirium as a Palliative Care Emergency
Bush, S. H. (2024) · Springer eBooks · doi:10.1007/978-3-319-31738-0_87-3
Development and validation of a prediction model for moxifloxacin-induced delirium in patients with community-acquired pneumonia: a retrospective cross-sectional studyPreprint
Xue, P., Li, P., Lin, L., Deng, Z., & Chen, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4725458/v1
Incidence of Delirium in ICU Patients With and Without COVID-19 in a Costa Rican Hospital
Zavaleta‐Monestel, E., Vargas, E. M., Chaverri‐Fernández, J. M., Díaz‐Madriz, J. P., Fallas-Mora, A., Alvarado-Ajun, P., Rojas-Chinchilla, C., & García-Montero, J. (2024) · Cureus · doi:10.7759/cureus.70007
“Currently, the use of antipsychotics for delirium prevention remains controversial, with varied study results [36-41].”
Background
Delir
Strube, W., & Häckert, J. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21442-4.00029-2
The Spectrum of Delirium
Long, T., & Wilson, L. (2024) · Topics in Geriatric Care. · doi:10.1007/978-981-97-5995-8_10
Clear Minds: Unravelling Delirium in Older Adults
Tumbali, Y., Inventor, B. R., & Paun, O. (2024) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20241015-03
A Secondary Analysis of the Prevalence and Clinical Profile of Psychiatric Referrals of Delirium in a Tertiary Care Hospital in Central India
Mishra, S., Mudgal, V., Mathur, R., Niranjan, V., & Pal, V. S. (2024) · Cureus · doi:10.7759/cureus.74797
“Haloperidol has been a traditional choice for managing delirium, but there is growing recognition of the potential risks associated with its use, including extrapyramidal symptoms [31].”
Principles of Geriatric Psychiatry
Teixeira, A. L., & Gatchel, J. R. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009334730.014
Delirium
Hosie, A., Amgarth‐Duff, I., & Agar, M. R. (2024) · Springer eBooks · doi:10.1007/978-3-031-48991-4_22
Eficacia del acompañamiento familiar y de medidas ambientales para reducir la incidencia de delirio en una unidad de agudos cardiovasculares: un estudio cuasi-experimental. Reducir el delirio sin fármacos es posible, es mejor
Guerra-Sánchez, L., González-Alfonso, S., Lerma-Lara, P., Bernardino-Santos, M., Cortijo-González, R., & Bustamante-González, S. (2025) · Enfermería Intensiva · doi:10.1016/j.enfi.2025.500546
A Comparison of Monotherapy and Combination Therapy With Antipsychotic Medications for Intensive Care Unit Delirium: A Retrospective Cohort Study
Nguyen, A., Chang, J., Allison-Aipa, T., & Albini, P. T. (2025) · Annals of Pharmacotherapy · doi:10.1177/10600280251322199
“…trials have found no significant difference in delirium duration or hospital/ ICU length of stay between antipsychotic therapy and placebo, 15 we decided it was more prudent to focus on differences between administering a single antipsychotic agent versus multiple agents and their impact…”
Influential
The effectiveness of family accompaniment and environmental measures to reduce the incidence of delirium incidence in an acute cardiovascular unit: A quasi-experimental study. It is possible to reduce delirium without using drugs, and it is better
Guerra-Sánchez, L., González-Alfonso, S., Lerma-Lara, P., Bernardino-Santos, M., Cortijo-González, R., & Bustamante-González, S. (2025) · Enfermería Intensiva (English ed ) · doi:10.1016/j.enfie.2025.500546
Efficacy of Brexpiprazole Augmentation in Sundown Syndrome and Cognitive Impairment
Hsu, C.-L., Lee, C.-C., Hu, J., & Huang, C.-C. (2025) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001937
Intraoperative temporal interference (TI)-noninvasive brain stimulation prevents postoperative delirium in mice
Liu, L., Wang, Y., Wang, H., Wu, H., Xue, R., Zhang, X., Tang, J., Wang, Z., Gu, T., Wang, D., et al. (2025) · Fundamental Research · doi:10.1016/j.fmre.2025.08.001
“However, the heterogeneity of phenotypes in patients with POD gives rise to a severe complication in individual identiﬁcation, which signiﬁcantly hinders the innovation of preventive and therapeutic strategies for POD [ 16 , 17 ].”
Causal Discovery on the Effect of Antipsychotic Drugs on Delirium Patients in the ICU using Large Observational EHR Dataset
Adib, R., Gani, M. O., Ahamed, S. I., & Adibuzzaman, M. (2025) · IEEE Annual International Computer Software and Applications Conference (COMPSAC) · doi:10.1109/compsac65507.2025.00031
“However, several randomized controlled trials (RCTs) have shown either conflicting or inconclusive results about the efficacy of APD in treating delirium [9], [10].”
Risk Factors and Clinical Outcomes of Postoperative Delirium in Patients Receiving Surgical Fixation for Osteoporotic Hip Fractures
Lee, D. H., Chang, C., Chen, Y., & Tai, T. (2025) · Formosan Journal of Musculoskeletal Disorders · doi:10.4103/fjmd.fjmd-d-25-00004
Effects of Implementation of a Standardized, Interdisciplinary Algorithm on Prevalence, Treatment, and Outcomes of Delirium in Medical Inpatients
Schmutz, N. A., Bachmann, L. M., Beck, T., Rindlisbacher, R., Eichelberger, M., Baumgartner, C., & Wertli, M. M. (2025) · Journal of General Internal Medicine · doi:10.1007/s11606-025-10058-y
Cognitive function monitoring
Bilotta, F., Prus, K., & Pisano, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32902-9.00016-7
Additional file 1 of Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit
Bush, S. H., Skinner, E., Lawlor, P. G., Dhuper, M., Grassau, P. A., Pereira, J. L., MacDonald, A. R., Parsons, H. A., & Kabir, M. (2022) · Figshare · doi:10.6084/m9.figshare.20324727
Additional file 1 of Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review
Colantuoni, E., Koneru, M., Akhlaghi, N., Li, X., Hashem, M. D., Dinglas, V. D., Neufeld, K. J., Harhay, M. O., & Needham, D. M. (2021) · Figshare · doi:10.6084/m9.figshare.14634018
Self-citation
Additional file 1 of Efficacy of quetiapine for delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial
Thanapluetiwong, S., Ruangritchankul, S., Sriwannopas, O., Chansirikarnjana, S., Ittasakul, P., Ngamkala, T., Sukumalin, L., Charernwat, P., Saranburut, K., & Assavapokee, T. (2021) · Figshare · doi:10.6084/m9.figshare.14355514
Additional file 3 of Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit
Bush, S. H., Skinner, E., Lawlor, P. G., Dhuper, M., Grassau, P. A., Pereira, J. L., MacDonald, A. R., Parsons, H. A., & Kabir, M. (2022) · Figshare · doi:10.6084/m9.figshare.20324733
Additional file 4 of Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit
Bush, S. H., Skinner, E., Lawlor, P. G., Dhuper, M., Grassau, P. A., Pereira, J. L., MacDonald, A. R., Parsons, H. A., & Kabir, M. (2022) · Figshare · doi:10.6084/m9.figshare.20324736
Additional file 5 of Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit
Bush, S. H., Skinner, E., Lawlor, P. G., Dhuper, M., Grassau, P. A., Pereira, J. L., MacDonald, A. R., Parsons, H. A., & Kabir, M. (2022) · Figshare · doi:10.6084/m9.figshare.20324739
Additional file 2 of Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit
Bush, S. H., Skinner, E., Lawlor, P. G., Dhuper, M., Grassau, P. A., Pereira, J. L., MacDonald, A. R., Parsons, H. A., & Kabir, M. (2022) · Figshare · doi:10.6084/m9.figshare.20324730
Progress on the Assessment, Prediction and Intervention Measures of Postoperative Delirium in Elderly Patients
李, 晖. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113174
CNS Complications and Management After Adult Cardiac Surgery
Dabbagh, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-01256-2_11
Effectiveness of Music Therapy for Delirium in Acute Hospital Settings: A Scoping Review
Leonard, S., Henderson, E., & Mitchell, G. (2026) · Nursing Reports · doi:10.3390/nursrep16010023 · Cited by 1
“Despite long-standing international recommendations emphasising non-pharmacological approaches in delirium care [43,50–54], pharmacological agents such as antipsychotics and sedatives continue to be widely used, despite limited benefit and known risks [55–57].”
The American Psychiatric Association Practice Guideline for the Prevention and Treatment of Delirium: Updated Implications for Patient Care
Oldham, C. M., Fochtmann, L. J., & Crone, C. C. (2026) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20250203
Delirium II—Common Etiologies
Patten, R. V., Hallowell, E. S., Kamper, J. E., Jennette, K. J., & Kanser, R. J. (2026) · Springer eBooks · doi:10.1007/978-3-032-05880-5_7
Efficacy of intranasal insulin in reducing the incidence of postoperative delirium: A systematic review and meta-analysis of randomised controlled trials
Desai, A., Bisht, R., Mogrovejo, E. M., Maheshwari, V., Misra, S., Joshi, M., & Bhardwaj, A. (2026) · Journal of Perioperative Practice · doi:10.1177/17504589261421004
EyeControl Communication Platform for Delirium Management in ICUs
Janga, S. R., Nguyen, V., Behera, A., Chen, G., Gavrilov, Y., Bendavid, I., Mayo, A., Subramaniam, B., & Bose, S. (2026) · CHEST Critical Care · doi:10.1016/j.chstcc.2026.100254
Predictors of Postictal Delirium Following Electroconvulsive Therapy in a Sample of Patients With Schizophrenia: An Egyptian Experience
Okasha, T. A., Khalil, S., Mohamed, R. S., Abdelhamid, S., & Mansour, O. (2026) · Journal of Ect · doi:10.1097/yct.0000000000001267
Pragmatic Strategies for Delirium Screening and Management in Older Long-term Care Facility Residents: A Comprehensive Review
Morandi, A., Fick, D. M., Szczerbinska, K., Ferrara, M. C., Wojszel, Z. B., Dreher, R., Carey, E., Oh, E., Kassidakis, P., Rodrigues, A., et al. (2026) · Delirium · doi:10.56392/001c.161804
Central nervous system–active medication polypharmacy and risk for nursing home admission among adults with early-onset dementia: A retrospective cohort study
Shrestha, N., Chiang, C., & Wei, Y. J. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261472831
Medicamentos potencialmente inapropiados en el adulto mayor en servicios de urgencias: una revisión narrativa
Bañuelos-Huerta, R., Aguilar-Lazcano, E. Y., Ramírez-Barranco, M., Hernández-Hernández, J. L., Sandoval-Hernández, J. C., & Uriel, C.-V. (2026) · Archivos de Medicina de Urgencia de México · doi:10.35366/123748
Detected Delirium Prevalence and Practices in Australia and New Zealand: A Sub‐Analysis of the World Delirium Awareness Day Prevalence Study
Huang, S., Welschinger, R., Aggar, C., Bail, K. S., Cusworth, E., Docherty, E. A., Fong, M., Groenewald, E., Hopkins, J., Hopkins, J., et al. (2026) · Australian Journal on Ageing · doi:10.1111/ajag.70227
Specialized Delirium Care Environments in Hospitalized Older Adults: A Systematic Review
Perrin, H., Mastria, G., Manjon, A. G., & D’Amelio, P. (2026) · Geriatrics · doi:10.3390/geriatrics11050122
Serum C1q as a Novel Predictive Biomarker for Postoperative Delirium After Acute Type A Aortic Dissection
Wang, J., Jiang, Y., Liu, W., Wang, Y.-P., Lu, S., zhu, J., Cai, X., Tian, Y., Cheng, Y., Wang, D., et al. (2026) · Immunity Inflammation and Disease · doi:10.1002/iid3.70500

Authors: Neufeld, K. J., Yue, J., Robinson, T. N., Inouye, S. K., & Needham, D. M.
Affiliations: Johns Hopkins University (US)
Sichuan University (CN)
University of Colorado Anschutz (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Neufeld, Karin J.
ORCID: Neufeld, Karin J.
Yue, Jirong
Inouye, Sharon K.
Needham, Dale M.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2016-03-23
Volume: 64
Issue: 4
Pages: 705-714
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/jgs.14076
PMC: PMC4840067
OpenAlex: W2310520207
Cited by: 505
References: 46
Citations by year: 2026: 29 · 2025: 39 · 2024: 58 · 2023: 52 · 2022: 41 · 2021: 42 · 2020: 59 · 2019: 65 · 2018: 56 · 2017: 49 · 2016: 15
FWCI: 9.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: John A. Hartford Foundation (2009–0079)
National Institute on Aging (K07AG041835, P01AG031720)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Keywords: antipsychotic drugs, delirium, delirium prevention, delirium management, hospitalized adults, surgical patients, medical inpatients, postoperative delirium, delirium duration, delirium severity, length of hospital stay, mortality, atypical antipsychotics, typical antipsychotics
MeSH terms: Adult, Delirium, Hospitalization, Humans, Antipsychotic Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antipsychotic medication for prevention and treatment of delirium in hospitalized adults: a systematic review and meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks