Should the Incretin hype be the same for older adults: Promise + cautions
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Older adults are at risk of worsening age-related sarcopenia and osteoporosis and were largely underrepresented in landmark incretin clinical trials.
“This is especially true for older adults, who are at risk of worsening age-related sarcopenia and osteoporosis and were largely underrepresented in the study populations for these landmark clinical trials (44).”
From The Benefits of Exercise Training in Combination With Weight Loss Therapies (2025) · cites this paper as [44]
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Cites
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
Lincoff, A. M., Brown-Frandsen, K., Colhoun, H. M., Deanfield, J., Emerson, S. S., Esbjerg, S., Hardt-Lindberg, S., Hovingh, G. K., Kahn, S. E., Kushner, R. F., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2307563 · Cited by 3,236 · see citing works
(2020) · PubMed · Cited by 2,642 · see citing works
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Self-citationAerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults
Villareal, D. T., Aguirre, L., Gurney, A. B., Waters, D. L., Sinacore, D. R., Colombo, E., Armamento-Villareal, R., & Qualls, C. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1616338 · Cited by 754 · see citing works
Self-citationHeymsfield, S. B., Gonzalez, M. C. C., Shen, W., Redman, L., & Thomas, D. (2014) · Obesity Reviews · doi:10.1111/obr.12143 · Cited by 350 · see citing works
Heerspink, H. J. L., Apperloo, E., Davies, M., Dicker, D., Kandler, K., Rosenstock, J., Sørrig, R., Lawson, J., Zeuthen, N., & Cherney, D. (2023) · Diabetes Care · doi:10.2337/dc22-1889 · Cited by 98 · see citing works
Ozoor, M., Gritz, M., Dolor, R. J., Holtrop, J. S., & Luo, Z. (2023) · PLOS ONE · doi:10.1371/journal.pone.0266217 · Cited by 11 · see citing works
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The Benefits of Exercise Training in Combination With Weight Loss Therapies
Jiang, B. C., & Villareal, D. T. (2025) · Diabetes · doi:10.2337/dbi25-0001 · Cited by 9 · see citing works
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- Authors
- Batsis, J. A., Porter Starr, K. N., & Villareal, D. T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Geriatric Research Education and Clinical Center (GRECC) Durham Veterans Affairs Health Care System Durham North Carolina USA
- Michael E. DeBakey VA Medical Center (US)
- Corresponding author
- Batsis, John A.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2024-02-23
- Volume
- 72
- Issue
- 7
- Pages
- 2266-2268
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC11226360
- OpenAlex
- W4392111560
- Cited by
- 8
- References
- 7
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- UNC Libraries
- Funders
- National Institute on Aging (R01‐AG077163)
- U.S. Department of Veterans Affairs (I01 CX002161)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01‐DK109950)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- incretins, older adults, glycemic control, GLP-1 receptor agonists, DPP-4 inhibitors
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Glucagon-Like Peptide 1, Incretins
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