The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Comparison of targeted web-based advertising versus traditional methods for recruiting older adults into clinical trials
Open accessAbstract
Background: Recruiting older adults into clinical trials can be particularly challenging. Our objective was to determine if targeted web‐based advertising is an effective recruitment strategy. Methods: We compared the recruitment rates of traditional and targeted web‐based methods for three representative clinical trials involving older adults. All studies utilized traditional recruitment methods initially, but shifted toward primarily targeted web‐based advertising after experiencing slow recruitment rates. Results: We found that web‐based advertising reached more individuals compared to traditional methods. Compared to traditional methods, web‐based methods also had at least twice the rate of expressed interest, completion of telephone and in‐person screening, eligibility, and enrollment. Additionally, the proportion of individuals excluded after the telephone screening did not differ according to whether targeted web‐based advertising (STAMINA: 51%; Berries and Steps: 62%; ISTIM: 20%) or traditional methods (STAMINA: 48%; Berries and Steps: 69%; ISTIM: 23%) were used within each study. Those recruited using web‐based advertisements tended to be younger compared to traditional methods, but were similar in racial distribution and education. Conclusion: Targeted web‐based advertisements may be more effective in recruiting older adults for clinical trials at a faster rate than traditional recruitment methods, but need further evaluation of compatible study designs, potential population bias, and cost‐effectiveness.
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The study cohort was predominately white and well-educated, which is a limitation of this work.
“we reported that the study cohort was predominately white and well-educated,34 which is a limitation of this work.”
From A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease (2025) · cites this paper as [34]
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The Use of Social Media in Recruitment for Medical Research Studies: A Scoping Review
Topolovec‐Vranic, J., & Natarajan, K. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5698 · Cited by 496
Clinical trials: The challenge of recruitment and retention of participants
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Online Patient Recruitment in Clinical Trials: Systematic Review and Meta-Analysis
Brøgger‐Mikkelsen, M., Ali, Z., Zibert, J. R., Andersen, A. D., & Thomsen, S. F. (2020) · Journal of Medical Internet Research · doi:10.2196/22179 · Cited by 167
Konrat, C., Boutron, I., Trinquart, L., Auleley, G.-R., Ricordeau, P., & Ravaud, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033559 · Cited by 164
Clinical trials in older people
Pitkälä, K. H., & Strandberg, T. E. (2022) · Age and Ageing · doi:10.1093/ageing/afab282 · Cited by 154
Carter‐Harris, L., Ellis, R. J. B., Warrick, A., & Rawl, S. M. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5502 · Cited by 103
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Shadbolt, C., Naufal, E. R., Bunzli, S., Price, V., Rele, S., Schilling, C. G., Thuraisingam, S., Lohmander, S. L., Balogh, Z. J., Clarke, P., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.50996 · Cited by 33
Bracken, K., Hague, W. E., KEECH, A. C., Conway, A. J., Handelsman, D. J., Grossmann, M., Jesudason, D. R., Stuckey, B. G. A., Yeap, B. B., Inder, W. J., et al. (2019) · Trials · doi:10.1186/s13063-019-3485-2 · Cited by 26
Advertising for Cognitive Interviews
Head, B. F., Dean, E., Flanigan, T. S., Swicegood, J., & Keating, M. D. (2015) · Social Science Computer Review · doi:10.1177/0894439315578240 · Cited by 21
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Millar, C. L., Iloputaife, I., Baldyga, K., Kuo, J., Tchkonia, T., Kirkland, J. L., Travison, T. G., & Lipsitz, L. A. (2023) · Translational Medicine of Aging · doi:10.1016/j.tma.2023.10.004 · Cited by 14
Self-citationTsaltskan, V., Nguyen, K., Eaglin, C., et al. (2022) · ACR Open Rheumatology · doi:10.1002/acr2.11448 · Cited by 13
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Millar, C. L., Iloputaife, I., Baldyga, K., Norling, A. M., Boulougoura, A., Vichos, T., Tchkonia, T., Deisinger, A., Pirtskhalava, T., Kirkland, J. L., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105612 · Cited by 88
“34 Additional recruitment methods included senior housing presentations, study fl yers at clinical practices, and invitations to previous research volunteers who agreed to be in our participant registries.”
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Metadata
- Authors
- Baldyga, K., Iloputaife, I., Taffet, G., LaGanke, N., Manor, B., Lipsitz, L. A., & Millar, C. L.
- Affiliations
- Hebrew SeniorLife (US)
- Baylor College of Medicine (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Baldyga, Kathryn
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2024-10-16
- Volume
- 73
- Issue
- 1
- Pages
- 182-192
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC11735267
- OpenAlex
- W4403452688
- Cited by
- 4
- References
- 14
- Citations by year
- 2026: 2 · 2025: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute on Aging (P30 AG031679, P30 AG048785, R01 AG059089, R21 AG073886)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Social Sciences › Health › Social Media in Health Education
- Social Sciences › Business, Management and Accounting › Organizational Behavior and Human Resource Management › Employer Branding and e-HRM
- Keywords
- clinical trial recruitment, older adults, recruitment strategies, participant enrollment, telephone screening, eligibility screening, population bias, cost-effectiveness
- MeSH terms
- Advertising, Aged, Aged, 80 and over, Clinical Trials as Topic, Female, Humans, Male, Patient Selection, Internet
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