The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Mechanical regulation of mesenchymal stem cell differentiation
Open accessAbstract
Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play are still not fully understood. This review article first describes the roles of both substrate mechanics (e.g. stiffness and topography) and extrinsic mechanical cues (e.g. fluid flow, compression, hydrostatic pressure, tension) on the differentiation of MSC s. A specific focus is placed on the role of such factors in regulating the osteogenic, chondrogenic, myogenic and adipogenic differentiation of MSC s. Next, the article focuses on the cellular components, specifically integrins, ion channels, focal adhesions and the cytoskeleton, hypothesized to be involved in MSC mechanotransduction. This review aims to illustrate the strides that have been made in elucidating how MSC s sense and respond to their mechanical environment, and also to identify areas where further research is needed.
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Cites
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
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Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies
Chimene, D., Kaunas, R., & Gaharwar, A. K. (2020) · Advanced Materials · doi:10.1002/adma.201902026 · Cited by 600
Advances and challenges in stem cell culture
McKee, C., & Chaudhry, G. R. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.07.051 · Cited by 323
Yi, B., Xu, Q., & Liu, W. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.12.005 · Cited by 304
Damaraju, S. M., Shen, Y., Elele, E., Khusid, B., Eshghinejad, A., Li, J., Jaffe, M., & Arinzeh, T. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.024 · Cited by 265
Cell Migration Assays and Their Application to Wound Healing Assays—A Critical Review
Yang, C., Yin, D., Zhang, H., Badea, I., Yang, S.-M., & Zhang, W. (2024) · Micromachines · doi:10.3390/mi15060720 · Cited by 22
Metadata
- Authors
- Steward, A. J., & Kelly, D. J.
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 2014-11-09
- Volume
- 227
- Issue
- 6
- Pages
- 717-731
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- OpenAlex
- W2126092026
- Cited by
- 263
- References
- 131
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
